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De novo gene birth and the conundrum of ORFan genes in bacteria [REVIEW]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
CGC1, a new reference genome for Caenorhabditis elegans [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A novel multislice framework for precision 3D spatial domain reconstruction and disease pathology analysis [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq [RESOURCES]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Androgen receptor-mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Mitotic chromosomes harbor cell type- and species-specific structural features within a universal loop array conformation [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Batch correction methods used in single-cell RNA sequencing analyses are often poorly calibrated [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
QuadST identifies cell-cell interaction-changed genes in spatially resolved transcriptomics data [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Overcoming limitations to customize DeepVariant for domesticated animals with TrioTrain [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Cancer driver topologically associated domains identify oncogenic and tumor-suppressive lncRNAs [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry [METHOD]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
The hidden costs of imperfection: transcription errors in protein aggregation diseases
At first glance, biological systems appear to operate with remarkable precision and order. Yet, closer examination reveals...
Spliceosome complex and neurodevelopmental disorders
The spliceosome catalyzes precursor messenger RNA (pre-mRNA) splicing, a function carried out by a ribonucleoprotein (RNP)...
Biological roles of nonsense-mediated RNA decay: insights from the nervous system
Nonsense-mediated RNA decay (NMD) is a highly conserved pathway originally discovered by virtue of its ability to recogniz...
Transcriptional adaptation: where mRNA decay meets genetic compensation
Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control mechanism that safeguards cells against faulty...
The HNRNPs and neurodevelopmental disorders
The HNRNP gene family encodes for over 30 distinct heterogeneous nuclear ribonucleoproteins [1]. These RNA-binding protein...
NOVA1/2 genes and alternative splicing in neurodevelopment
Volume 93, August 2025, 102373Author links open overlay panelNOVA1 and NOVA2 are neuron-specific RNA-binding proteins esse...
Unlocking regeneration: how partial reprogramming resembles tissue healing
Partial reprogramming achieved by the transient expression of the transcription factors (TFs) Oct4, Sox2, Klf4 and C-Myc (...
Molecular basis of cell fate plasticity — insights from the privileged cells
In the post-Yamanaka era, the rolling balls on Waddington’s hilly landscape not only roll downward, but also go upward or ...
Stem cell models of human embryo implantation and trophoblast invasion
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