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Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
To analyze the efficacy and safety of Janus kinase inhibitors (JAKi) in the treatment of pediatric AD. Adolescents with mo...
Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond
Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond
In the last decade, an increasing trend towards a supposedly healthier vegan diet could be observed. However, recently, mo...
Impact of Enolase in Allergic Disease
Impact of Enolase in Allergic Disease
There is growing evidence that enolase is involved in allergy. This manuscript reviews the impact of enolase in allergic d...
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-onset systemic lupus erythematosus (cSLE) is a severe and potentially life-threatening chronic autoimmune diseas...
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporins are one of the most prescribed antibiotics worldwide and are implicated in a wide range of hypersensitivity...
Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review
Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review
COVID -19 associated olfactory dysfunction is widespread, yet effective treatment strategies remain unclear. This article ...
Getting in Shape: Updates in Exercise Anaphylaxis
Getting in Shape: Updates in Exercise Anaphylaxis
Exercise induced anaphylaxis (EIA) can be difficult to diagnose due to the interplay of co-factors on clinical presentatio...
Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 – Aeroallergen Protein Families
Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 – Aeroallergen Protein Families
Respiratory allergies are non-communicable diseases caused by the hypersensitivity of the immune system to environmental a...
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
There is an incomplete understanding regarding the extent of endoscopic sinus surgery (ESS) in managing chronic rhinosinus...
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Clinical interest in non-IgE activation of mast cells has been growing since the description of the human MRGPRX2 receptor...
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory dysfunction significantly impacts quality of life that affects a majority of the patients with chronic rhinosinu...
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Food allergies are immune-mediated, complex disorders, which are the source of increasing health concern worldwide. The go...
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
We aimed to reach an Italian multidisciplinary consensus on some crucial aspects of treatment decision making in CRSwNP, f...
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Mast cell (MC) activation syndromes (MCAS) are conditions defined by recurrent episodes of severe systemic anaphylaxis or ...
Precautionary Allergen Labeling: Avoidance for All?
Precautionary Allergen Labeling: Avoidance for All?
Precautionary allergen labeling (PAL) suggests the risk of unintended allergen presence (UAP) in food but is unregulated i...
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in contex...
Recent Insights into the Environmental Determinants of Childhood Asthma
Recent Insights into the Environmental Determinants of Childhood Asthma
Ubiquitous environmental exposures, including ambient air pollutants, are linked to the development and severity of childh...
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights r...
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfac...
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
To provide an overview on the current understanding of genetic variability in human tryptases and summarize the literature...
Fungal Sensitization and Human Allergic Disease
Fungal Sensitization and Human Allergic Disease
Fungal sensitizations have been associated with hypersensitivity reactions with variable levels of evidence available to l...
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Chronic spontaneous urticaria and chronic inducible urticaria (CSU/CindU) are caused by mast cell and basophil activation ...
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
With increasing industrialization, exposure to ambient and wildfire air pollution is projected to increase, necessitating ...
Effects of Endoscopic Sinus Surgery on Olfactory Function
Effects of Endoscopic Sinus Surgery on Olfactory Function
To review the effects of endoscopic sinus surgery and endonasal approaches to the skull base on olfaction. Advancements in...
Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP
Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP
Three biologics targeting type 2 inflammation have been approved for the treatment of severe and uncontrolled chronic rhin...
Endoscopic Extended Sinus Surgery for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps, the Choice of Mucoplasty: A Systematic Review
Endoscopic Extended Sinus Surgery for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps, the Choice of Mucoplasty: A Systematic Review
The advances in the knowledge of the molecular basis of the inflammatory response in chronic rhinosinusitis with nasal pol...
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach
A modified Delphi process was undertaken to provide a US expert-led consensus to guide clinical action on short-acting bet...
Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis
Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis
To analyze and compare the effects of epistaxis treatments for Hereditary Hemorrhagic Telangiectasia (HHT) patients. Of to...
Neuromyelitis Optica: Pathogenesis Overlap with Other Autoimmune Diseases
Neuromyelitis Optica: Pathogenesis Overlap with Other Autoimmune Diseases
Neuromyelitis optica (NMO) is an auto-immune disease essentially depicted by optic neuritis and transverse myelitis. Per s...
An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a complicated, heterogeneous disease likely caused by inflammatory and infectious factors....
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