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Sepsis criteria and kidney function: eliminating sex, age and economic status biases
Sepsis criteria and kidney function: eliminating sex, age and economic status biases
The kidney is a target organ for the dysregulated host response to infection that defines sepsis, and acute kidney injury ...
Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease management
Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease management
Genetic investigations in nephrology have long been viewed as the prerogative of paediatricians or restricted to archetypa...
Leveraging data as a patient–scientist: frustrations and opportunities
Leveraging data as a patient–scientist: frustrations and opportunities
The transition from data scientist to patient–scientist has given me new perspectives into clinical research and str...
Effects of microplastics and nanoplastics on the kidney and cardiovascular system
Effects of microplastics and nanoplastics on the kidney and cardiovascular system
Microplastics and nanoplastics are ubiquitous environmental pollutants that contaminate air, food and water supplies, resu...
Fibroblast activation and heterogeneity in fibrotic disease
Fibroblast activation and heterogeneity in fibrotic disease
Fibroblasts are a special type of interstitial cell that has an essential role in maintaining the structural framework of ...
Harnessing plant thylakoids to restore cellular function in AKI
The kidney tubule is highly metabolically active and requires a constant supply of ATP for electrolyte and solute transpor...
Superior efficacy of empagliflozin and finerenone combination therapy versus monotherapy in patients with CKD and T2DM
New data from the CONFIDENCE trial show that combination therapy with a sodium–glucose cotransporter 2 (SGLT2) inhibitor, ...
The catastrophic costs of chronic kidney disease
The catastrophic costs of chronic kidney disease
Chronic kidney disease (CKD) is associated with the highest occurrence of catastrophic healthcare expenditure (CHE) both g...
A guide to gene–disease relationships in nephrology
A guide to gene–disease relationships in nephrology
The use of next-generation sequencing technologies such as exome and genome sequencing in research and clinical care has t...
ECM remodelling by ADAMTS12 in fibrosis
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stim...
Kidney disease and reproductive health
Kidney disease and reproductive health
Understanding the relationship between reproductive health and kidney function is important to provide holistic care for p...
Collagen formation, function and role in kidney disease
Collagen formation, function and role in kidney disease
Highly abundant in mammals, collagens define the organization of tissues and participate in cell signalling. Most...
Advancing gender equity to improve kidney care for women: a patient perspective
Women living with kidney disease are exposed to several sex and gender gaps in the clinical practice of standard hemodialy...
Contribution of APOL1 variants to CKD risk in West Africans
The G1 and G2 APOL1 risk alleles are important risk factors for chronic kidney disease (CKD) among Black Americans; howeve...
Consequence of microvascular inflammation in transplantation
Consequence of microvascular inflammation in transplantation
Recognition that allograft microvascular inflammation can occur in the absence of circulating donor-specific anti-HLA anti...
Immune–stromal interplay shapes kidney function in health and disease
Immune–stromal interplay shapes kidney function in health and disease
New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymp...
Clonal haematopoiesis and AKI
Clonal haematopoiesis of indeterminate potential (CHIP) arises from the clonal expansion of a mutated haematopoietic stem ...
Switching off SOX9 for epithelial recovery after AKI
Switching off SOX9 for epithelial recovery after AKI
In acute kidney injury (AKI), dysregulated tissue regeneration can promote fibrosis and chronic kidney disease. Sustained ...
Sex differences in kidney metabolism and DKD
Sex differences in kidney metabolism and DKD
The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of kidney failure in men. New data s...
The global landscape of kidney registries: immense challenges and unique opportunities
The global landscape of kidney registries: immense challenges and unique opportunities
Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustaina...
Kidney disease: a global health priority
Kidney disease: a global health priority
The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackle...
Combination therapy for kidney disease in people with diabetes mellitus
Combination therapy for kidney disease in people with diabetes mellitus
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear ca...
Chronic kidney disease and the global public health agenda: an international consensus
Chronic kidney disease and the global public health agenda: an international consensus
Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studi...
A new era in the science and care of kidney diseases
A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Noneth...
Progress towards improving blood pressure control
Progress towards improving blood pressure control
Despite the availability of effective therapies, the majority of patients with hypertension have poor blood pressure contr...
Consideration of sex differences is necessary to achieve health equity
Improved understanding of the impact of sex and gender-related factors on human health and disease and the inclusion of pe...
Targeted identification of risk and treatment of diabetic kidney disease
Basic discovery and clinical trials in diabetic kidney disease (DKD) have continued to be reported in 2023 despite the dis...
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Improved understanding of differences in kidney disease epidemiology, management and outcomes in men and women could help ...
Mechanisms and consequences of sex differences in immune responses
Mechanisms and consequences of sex differences in immune responses
Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is...
Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney
Authors and AffiliationsDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USAGeorge C. Tsokos, Afr...
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