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Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Abstract—Parkinson’s disease is a chronic neurodegenerative disease, one of the pathobiochemical manifestation...
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Extracellular adenosine 5′-triphosphate (ATP), as neurotransmitter, is known to be an activity-dependent signaling m...
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for th...
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Parkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly rela...
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract—The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (...
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
Epileptic seizures are caused by abnormal neuronal excitation. It is well established that carvacrol, a monoterpenoid phen...
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
Abstract—The study of the status of norepinephrine-, dopamine- and serotonergic neurotransmitter systems of BALB/C m...
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
Intracranial hemorrhage (ICH) is the most critical secondary lesion of traumatic brain injury (TBI). Identifying novel bio...
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Sugammadex (SUG) is a modified γ-cyclodextrin molecule used in patients under general anesthesia to reverse the effec...
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Two periods of autophagy activation with a different significance for the development of resistance were demonstrated in t...
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Chronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT1A receptor (5-HT1AR) ...
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Post-stroke depressive disorders (PSD) and post-stroke cognitive impairments (PCI) are frequent consequences of ischemic s...
Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway
Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway
Glioma is the most common type of primary craniocerebral tumor. Understanding the molecular mechanisms of glioma occurrenc...
Effects of Intrathecal Administration of Prostaglandin-D2 on Stress-Induced Analgesia: Involvements of DP2 Receptors
Effects of Intrathecal Administration of Prostaglandin-D2 on Stress-Induced Analgesia: Involvements of DP2 Receptors
Prostaglandin D2 is the most abundant prostaglandin in the mammalian brain. Exposure to stressful stimuli is often accompa...
Graded Differentiation of Glioma in GSK-3 β: The Study and Analysis of the Expression Difference and Its Significance in the Endoplasmic Reticulum Stress Apoptosis Pathway
Graded Differentiation of Glioma in GSK-3 β: The Study and Analysis of the Expression Difference and Its Significance in the Endoplasmic Reticulum Stress Apoptosis Pathway
Glioma accounts for 80% of malignant central nervous system, with high incidence and extremely difficult to cure. However,...
Quantitative Characteristics of Small Extracellular Vesicles from the Blood of Patients with Non-Suicidal Self-Injury
Quantitative Characteristics of Small Extracellular Vesicles from the Blood of Patients with Non-Suicidal Self-Injury
Abstract—The aim of the study was to determine the quantitative characteristics of small extracellular vesicles (sEV...
Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Abstract—Coordinated regulation of energy conversion processes in the brain maintains its highly productive work and...
Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review
Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review
In recent years, neurodegenerative diseases (NDs) have increased around the world and current treatments only provide temp...
Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor
Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor
Abstract—Nerve growth factor (NGF) is a factor which determines neuronal differentiation. NGF plays an important rol...
Optical Characteristics and Neuroprotective Properties of β-Dimethylaminoethylamide N-Benzoyl-DL-valine Iodmethylate and 1-(β-Diethylaminoethyl)-2-phenyl-4-benzylidene-5-imidazolone
Optical Characteristics and Neuroprotective Properties of β-Dimethylaminoethylamide N-Benzoyl-DL-valine Iodmethylate and 1-(β-Diethylaminoethyl)-2-phenyl-4-benzylidene-5-imidazolone
The water and DMSO solutions of two new synthesized compounds, β-dimethylaminoethylamidine N-benzoyl-DL-valineiodomet...
The Transition of Pain into Anesthesia—The Effect of Various Doses of Macrovipera lebetina obtusa Venom
The Transition of Pain into Anesthesia—The Effect of Various Doses of Macrovipera lebetina obtusa Venom
Blunt-nosed viper venom in high doses causes severe pain, while in low doses an analgesic effect is observed. The opposite...
Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxi...
Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration
Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration
The search for effective treatment for neurodegeneration implies attacking the multiple mechanisms of this pathology. Such...
T-Cell Aspects of Some Neurological Diseases
T-Cell Aspects of Some Neurological Diseases
Abstract—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barr...
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Alzheimer’s disease is an age-associated progressive disorder, characterized by neurodegeneration and following cogn...
Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression
Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression
Abstract—Characteristics of small extracellular vesicles (sEVs) and sEVs composition are far from being well-studied...
Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
The search for biological markers of neurodegenerative diseases, namely, Alzheimer’s (AD) and Parkinson’s (PD)...
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
This study aimed to explore the efficacy of Xingnaojing combined with brain glycoside peptide (XCGP) in the treatment and ...
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Abstract—The aim of this study was to identify and compare changes in serum concentrations of heat shock proteins (H...
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
Abstract—According to the Alzheimer’s Disease International (ADI) international organization about 50 million ...
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