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Quantitative Characteristics of Small Extracellular Vesicles from the Blood of Patients with Non-Suicidal Self-Injury
Quantitative Characteristics of Small Extracellular Vesicles from the Blood of Patients with Non-Suicidal Self-Injury
Abstract—The aim of the study was to determine the quantitative characteristics of small extracellular vesicles (sEV...
Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Abstract—Coordinated regulation of energy conversion processes in the brain maintains its highly productive work and...
Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review
Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review
In recent years, neurodegenerative diseases (NDs) have increased around the world and current treatments only provide temp...
Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor
Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor
Abstract—Nerve growth factor (NGF) is a factor which determines neuronal differentiation. NGF plays an important rol...
Optical Characteristics and Neuroprotective Properties of β-Dimethylaminoethylamide N-Benzoyl-DL-valine Iodmethylate and 1-(β-Diethylaminoethyl)-2-phenyl-4-benzylidene-5-imidazolone
Optical Characteristics and Neuroprotective Properties of β-Dimethylaminoethylamide N-Benzoyl-DL-valine Iodmethylate and 1-(β-Diethylaminoethyl)-2-phenyl-4-benzylidene-5-imidazolone
The water and DMSO solutions of two new synthesized compounds, β-dimethylaminoethylamidine N-benzoyl-DL-valineiodomet...
The Transition of Pain into Anesthesia—The Effect of Various Doses of Macrovipera lebetina obtusa Venom
The Transition of Pain into Anesthesia—The Effect of Various Doses of Macrovipera lebetina obtusa Venom
Blunt-nosed viper venom in high doses causes severe pain, while in low doses an analgesic effect is observed. The opposite...
Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxi...
Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration
Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration
The search for effective treatment for neurodegeneration implies attacking the multiple mechanisms of this pathology. Such...
T-Cell Aspects of Some Neurological Diseases
T-Cell Aspects of Some Neurological Diseases
Abstract—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barr...
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Alzheimer’s disease is an age-associated progressive disorder, characterized by neurodegeneration and following cogn...
Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression
Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression
Abstract—Characteristics of small extracellular vesicles (sEVs) and sEVs composition are far from being well-studied...
Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
The search for biological markers of neurodegenerative diseases, namely, Alzheimer’s (AD) and Parkinson’s (PD)...
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
This study aimed to explore the efficacy of Xingnaojing combined with brain glycoside peptide (XCGP) in the treatment and ...
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Abstract—The aim of this study was to identify and compare changes in serum concentrations of heat shock proteins (H...
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
Abstract—According to the Alzheimer’s Disease International (ADI) international organization about 50 million ...
Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels
Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels
Parkinson’s disease is a progressive neurodegenerative disorder distinguished by degeneration of dopaminergic neuron...
Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor
Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor
The toxicity of chemotherapy agents to the peripheral nervous system (PNS) often manifests itself as chemotherapy-induced ...
Rapid Alterations of the Expression of Active Caspase-3 and Glucocorticoid Receptors in the Cells of the Striatum during Neuroinflammation
Rapid Alterations of the Expression of Active Caspase-3 and Glucocorticoid Receptors in the Cells of the Striatum during Neuroinflammation
Abstract—Activation of microglia, as resident immune cells of the central nervous system, plays a key role in the pa...
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy
This study is done to examine the microbiota in thrombi retrieved from the middle cerebral artery after mechanical thrombe...
Metabolic Plasticity in Developing and Aging Brain
Metabolic Plasticity in Developing and Aging Brain
Abstract—Brain plasticity is a fundamental phenomenon based on various types of intercellular interactions (synaptic...
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains
Abstract—Repeated fighting experiences can lead to changes in the neurophysiology and behavior of animals and to the...
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurological condition that is accompanied by cognitive decline. The occur...
The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region
The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region
Abstract—We studied the role of the rs1800629 polymorphism of the TNF-α gene; the rs4149584 polymorphism of the...
The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
Abstract—Depressive disorders and alcohol dependence are among the most common psychopathologies. It is known that d...
Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Epilepsy results from abnormal brain function and is one of the most common neurological diseases in the world. The phosph...
Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine
Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine
Abstract—The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not ful...
Differences in Changes in the Glutamate/GABA System Activity in the Rat Retina during Aging and the Development of Retinopathy at Nighttime and Daytime
Differences in Changes in the Glutamate/GABA System Activity in the Rat Retina during Aging and the Development of Retinopathy at Nighttime and Daytime
Abstract—Age is a leading risk factor for the development of age-related macular degeneration (AMD), which is the ca...
Structure, Function and Distribution of ATP8A2 in Human and Mice
Structure, Function and Distribution of ATP8A2 in Human and Mice
ATP8A2 can translocate phospholipids from exoplasmic to the cytoplasmic leaflets to establish and maintain the lipid asymm...
Antioxidant Effects of Crataegus laevigata on Rat’s Brain under Hypobaric Hypoxia-Induced Oxygen Deficiency
Antioxidant Effects of Crataegus laevigata on Rat’s Brain under Hypobaric Hypoxia-Induced Oxygen Deficiency
Acute hypobaric hypoxia induces various pathological mechanisms that lead to the development of oxidative stress damaging ...
Markers of Neurodegeneration in Parkinson’s Disease
Markers of Neurodegeneration in Parkinson’s Disease
Abstract—This review describes the role of peripheral blood biomarkers involved in neurodegeneration and neuroregene...
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