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Antioxidant PRDX3 gene therapy protects brain cells and prevents neurodegeneration in an animal model of Parkinson's disease
Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer's disease and is closely ...
Transcranial pulsed current stimulation alleviates neuronal pyroptosis and neurological dysfunction following traumatic brain injury via the orexin-A/NLRP3 pathway
Traumatic brain injury (TBI) contributes to mortality and disability worldwide, with survivors often experiencing severe c...
Sucralose uses reward pathways to promote acute caloric intake
Sweet taste perception is a crucial evolutionary adaptation that allows organisms to recognize the nutritional value of fo...
The effects of corticotropin-releasing factor (CRF) and urocortins on the serotonin (hydroxytryptamine, 5HT) released from the raphe nuclei (RN)
Corticotropin-releasing factor (CRF) and the urocortins (UCN1, UCN2 and UCN3) belong to the same CRF family of neuropeptid...
Phoenixin-14 inhibits the formation of cerebral aneurysms in rats by downregulating the p38/NF-κB signaling pathway
Cerebrovascular diseases are the leading cause of death globally, with approximately one-fourth of cerebrovascular deaths ...
Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice
Neuropeptide Y (NPY), one of the most abundant neuropeptides in the brain (Allen et al., 1983; Reichmann and Holzer, 2016;...
Mechanistic role of proteins and peptides in Management of Neurodegenerative Disorders
Proteins and peptides play essential roles in almost all biochemical processes in the human body. As for example protein a...
BDNF-mediated depressor response by direct baroreceptor activation benefits for prevention and control of hypertension in high-latitude cold region
Hypertension is a chronic medical condition and a common complication of metabolic abnormalities in the cardiovascular sys...
Bioactive peptides as multipotent molecules bespoke and designed for Alzheimer's disease
Bioactive peptides (BPs) are a natural, safe, and cost-effective alternative to synthetic small-molecule and antibody-base...
Ginsenoside Rg1 improves autophagy dysfunction to ameliorate Alzheimer's disease via targeting FGR proto-oncogene
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive dysfunction (Scheltens...
Molecular mechanisms of GDNF/GFRA1/RET and PI3K/AKT/ERK signaling interplay in neuroprotection: Therapeutic strategies for treating neurological disorders
Neurological illnesses are characterised by the gradual degeneration and death of neurons in the central and peripheral ne...
Factors affecting the physical stability of peptide self-assembly in neurodegenerative disorders
Due to their varied amino acid sequences and predictable conformational properties, peptides play a crucial role in bioorg...
Profile of cocaine and amphetamine regulated transcript peptide (CARTp) and Corticotropin-releasing factor (CRF) in the brain of Euphlyctis cyanophlyctis during puddle desiccation
The intricate process of anuran development entails the change from an aquatic larval to an adult terrestrial stage. In In...
Astrocyte glucose-6-phosphatase-Beta regulates ventromedial hypothalamic nucleus glucose counterregulatory neurotransmission and systemic hormone profiles
Brain regulation of systemic glucose homeostasis involves a dedicated, expansive neural circuitry that extends throughout ...
Catestatin-like immunoreactivity in the skin and related sensory ganglia
AimThe chromogranin A-derived peptide catestatin has previously been shown to be a constituent of the sensory innervation ...
Acute sleep deprivation (ASD) and cardioprotection: Impact of ASD on oxytocin-mediated sympathetic nervous activation preceding myocardial infarction
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Chemogenetic activation of arcuate nucleus NPY and NPY/AgRP neurons increases feeding behaviour in mice
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Bromelain decreases oxidative stress and Neuroinflammation and improves motor function in adult male rats with cerebellar Ataxia induced by 3-acetylpyridine
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Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease
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Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish
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Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model
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Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature
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Melittin protects against neural cell damage in rats following ischemic stroke
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The restraint stress-induced antinociceptive effects decreased by antagonism of both orexin receptors within the CA1 region of the hippocampus
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Ninjinyoeito ameliorates anorexia and changes in peptide YY and ghrelin levels of cisplatin-treated mice
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Adrenomedullin-mediated depressor response with visceral afferent-specific membrane depolarization in isolated nodose ganglion neurons from adult female rat
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Enteroendocrine cell-derived peptide YY signalling is stimulated by pinolenic acid or Intralipid and involves coactivation of fatty acid receptors FFA1, FFA4 and GPR119
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NK1 receptor blockade disrupts microtumor growth and aggregation in a three-dimensional syngeneic breast cancer model
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Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance
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The protective effects of orexin B in neuropathic pain by suppressing inflammatory response
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