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Palladium-Catalyzed Endocyclic Bond Cleavage of Thioxanthene-derived Sulfonium Salts
The breaking of endocyclic S-aryl bond of strainless thioxanthene derivatives by transition metal-catalyzed ring-opening r...
Diels-Alder Reaction of Substituted Cyclopentadienones with Benzothiophene S, S-dioxides: Synthesis of Dibenzothiophenes, Dibenzothiophene S, S-dioxides, Acenaphthenes, Phenanthrenes, Pyrenes, and Fluorenones by Exploiting Thermolysis of Diels-Alder Adducts
Diels-Alder (DA) reaction of a series of tetra substituted cyclopentadienones (CPDs) with benzo[b]thiophene S, S-dioxide a...
Unraveling Steric and Dispersion Effects in Gold Catalysis: A DFT Study of Asymmetric Cyclization/Mannich Reactions
The cooperative catalysis between gold complexes and chiral phosphoric acids (CPA) enables asymmetric oxidative cyclizatio...
Metal-free cascade SNAr reaction/allylic amination enabled by triethylamine: a green chemistry access to tetrahydropteridines
Herein, we report a novel metal-free cascade SNAr reaction/allylic amination strategy for pyrimidinamine derivatives promo...
Synthesis of Highly Polysubstituted Cyclopentadienes through Oxypalladation Initiated Domino Heck Reactions of Internal Alkynes
We describe a facile approach to prepare a variety of densely polysubstituted cyclopentadiene derivatives in good yields (...
Chiral Bis-Phosphine Monoxide-Gold(I) Complex Enables Asymmetric Dearomative Cyclization of β-Naphthol Derivatives
Chiral phosphine ligands play a pivotal role in gold(I)-catalyzed asymmetric reactions, yet their efficacy is often constr...
Precipitation-Driven Diastereo- and Regioselective Macrocyclization via Benzoin Condensation: Effects of Solvents and Alkyl Chain Lengths
The benzoin condensation of a designed dialdehyde 1 with a terphenyl framework was investigated. When the reaction was car...
Photoinduced regio- and stereoselective C(sp2)–H fluoromethylthiolation of enamides
Vinyl fluoromethyl thioethers are widely employed as pivotal intermediates in organic synthesis and deemed as promising sc...
Sodium dithionite mediated reductive N-acetylation/formylation of nitroarenes employing DMAc/DMF as acetyl/formyl surrogates
The present invention discloses a unified strategy for N-acetylation/formylation directly from nitroarenes employing solve...
Сross-dehydrogenative C-O coupling of oximes with hydrazones: synthesis of fungicidal azo oxime ethers
The cross-dehydrogenative coupling (CDC) of oximes with hydrazones employing KMnO 4 as the oxidant was discovered.Presumab...
Mechanistic Insights into NHC/Cu Catalyzed Asymmetric Synthesis of Spirooxindole: Origins of Enantioselectivity and Diastereoselectivity
Density Functional Theory (DFT) calculations were conducted to elucidate the mechanism of NHC/Cu catalyzed enantioselectiv...
Dissipative formation of a transient foldaxane with a fuel-like thread
Transient assemblies generated by fuel consumption biomacromolecules are essential for biological processes. Although arti...
Photoredox β-C(sp3)-H Heteroarylation of o-Iodoaryl-alkan-1-ones with Heteroarenes via HAT and Dual C-H Functionalizations
A synthetically useful method for the formal β-heteroarylation of ketones via an iodoarene-directed photoredox remote C(sp...
Dual-State Emission of Pyrazolyl-Pyrrolo[3,4-b]pyridin-5-ones via Excited-State Intramolecular Proton Transfer (ESIPT): Multicomponent Synthesis and Optical Characterization
The dual-state emission (DSE) phenomenon has become crucial for developing dual-state emission luminogens (DSEgens) that e...
Recent advances in the synthesis of nitrogen heterocycles via Rh(III)-catalyzed chelation-assisted C-H activation/annulation with diazo compounds
Diazo compounds are a class of readily available and versatile reagents in modern organic synthesis that have been used as...
Mechanophoric hydrogels: when mechanical stress produces useful responses
Mechanophoric hydrogels undergo visible color changes or alterations in optical properties in response to mechanical stimu...
Core-Extended Nonastarazines Featuring Diverse Arm Configurations via One-Pot Sequential Reactions
This article presents the successful synthesis of a novel series of core-extended quasi-planar nonastarazine (NSA) derivat...
Photoredox-Catalyzed Generation of α-Carbonyl Carbocations: General Access to α-Tertiary Amino Acid Derivatives
α-Carbonyl carbocations, serving as the umpolung forms of the synthetically fundamental α-carbonyl carbanions, are highly ...
Cycloisomerization of 7-En-2-yn-1-ones to Bicyclo[3.1.0]hexanes Using Electrophilic Fluorination or Chlorination Agents
In contrast to the π-electrophilic transition metal-catalyzed cycloisomerization of enynes, systematic studies on the reac...
Biocatalytic atroposelective synthesis of heterobiaryls and heterobiaryl N-oxides via dynamic kinetic resolution
Heterobiaryl and heterobiaryl N-oxide atropisomers are important scaffolds in various chiral ligands, organocatalysts, and...
In situ generated cobalt(I) catalyst for the efficient synthesis of novel pyridines: Revisiting the mechanism of [2+2+2] cycloadditions
The [2+2+2] cycloaddition of alkynes and nitriles is an efficient and atom-economic method for the synthesis of pyridines....
Organocatalytic Asymmetric Desymmetrization of Cyclopentene-1,3-diones via Formal Diaza-ene Reaction with Donor–Acceptor Hydrazones
Herein we disclose a catalytic asymmetric desymmetrization of cyclopentene-1,3-diones via formal diaza-ene reaction/tautom...
A Protodefluorinated Selectfluor® Heteroaggregate Photoinduces Direct C(sp3)−H Fluorinations Without Photocatalyst
Herein, we uncover a hitherto hidden role of H-TEDA(BF4)2 – a cheap, stable, recoverable by-product of radical C(sp3)–H fl...
Deoxygenative ortho-Benzylation of Aryl Iodides with Benzyl Alcohol via Palladium/Norbornene Cooperative Catalysis
Herein, we demonstrate a robust palladium/norbornene-catalyzed deoxygenative ortho-benzylation of aryl iodides with non-de...
Transition metal-catalyzed redox-neutral 1,3-dienylation of propargylic esters and divergent synthesis
1,3-Dienes are important scaffolds that extensively exist in natural products and bioactive molecules. They are also valua...
Phosphine-Controlled Divergent Reactions of MBH-Carbonates with Azaheptafulvenes: Access to o-Anilinyl diene and Benzazepine Derivatives
We disclosed a phosphine catalysts controlled divergent cascade reaction of MBH-carbonates with azaheptafulvenes. In the p...
18F-Labelling of Nitrogen-containing Aryl Boronates − Anti-cancer Drug Melflufen as a Case Study
18F-Labelling of nitrogen-containing arenes via copper mediated radiofluorination (CMRF) was investigated. The studies tar...
A Cucurbit[8]uril-mediated Host-guest Complex for Red Light Photocatalysis
A red light supramolecular photocatalytic system is developed by fabricating a cucurbit[8]uril-mediated 3:2 host-guest com...
Asymmetric Synthesis of (Aza)flavanones by the Evolution of CarOx Ligands
Amino-pyridine-oxazoline (NHPyOx) is conceived as an unprecedented model via the core-emulating optimization of CarOx liga...
Photoredox copper-catalyzed regioselective syntheses of allenols via HAT-mediated propargyl radical generation
Selectivity control of the reactions of propargylic and/or allenylic radicals remains particularly elusive. Here, a visibl...
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