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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle ...
Nitric oxide and ion channels mediate l-cysteine-induced inhibition of colonic smooth muscle contraction
Nitric oxide and ion channels mediate l-cysteine-induced inhibition of colonic smooth muscle contraction
Previous studies have suggested that l-cysteine regulates gut motility through hydrogen sulfide. However, the mechanisms i...
Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
The transcriptional regulation of skeletal muscle (SKM) development (myogenesis) has been documented for over 3 decades an...
Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2: a mini-review
Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2: a mini-review
Skeletal muscle necrosis is a common clinical manifestation of snakebite envenoming. The predominant myotoxic components i...
The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis
The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis
This study aimed to explore the occurrence of necroptosis in skeletal muscle after eccentric exercise and investigate the ...
Protective effect of Luffa cylindrica Roemer against dexamethasone-induced muscle atrophy in primary rat skeletal muscle cells
Protective effect of Luffa cylindrica Roemer against dexamethasone-induced muscle atrophy in primary rat skeletal muscle cells
Glucocorticoids (GCs) are commonly used in the treatment of chronic inflammatory conditions. However, the administration o...
From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
Actin-myosin interactions form the basis of the force-producing contraction cycle within the sarcomere, serving as the pri...
John Squire: a leader and seminal contributor to experimental and theoretical muscle research for over 50 years
John Squire: a leader and seminal contributor to experimental and theoretical muscle research for over 50 years
This collection of papers aims to recognise and celebrate the life and scientific ach...
Correction: Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Correction: Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs
The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs
The Z-disk of striated muscle defines the ends of the sarcomere, which repeats many times within the muscle fiber. Here we...
Obituary: Professor John Michael Squire
Obituary: Professor John Michael Squire
In 1973 John joined Imperial College as lecturer in the Department of Metallurgy and Materials Science. This transition fr...
Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
Actin, tropomyosin and troponin, the proteins that comprise the contractile apparatus of the cardiac thin filament, are hi...
Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Challenging environmental conditions can drive the evolution of extreme physiological traits. The naked mole-rat has evolv...
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) leads to changes in the pump function of the heart and causes right-sided myocardial...
Molecular insights into titin’s A-band
Molecular insights into titin’s A-band
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important sc...
Bioinformatics analysis of paravertebral muscles atrophy in adult degenerative scoliosis
Bioinformatics analysis of paravertebral muscles atrophy in adult degenerative scoliosis
Paravertebral muscles (PVM) act as one of the major dynamic factors to maintain human upright activities and play a remark...
The vertebrate muscle superlattice: discovery, consequences, and link to geometric frustration
The vertebrate muscle superlattice: discovery, consequences, and link to geometric frustration
Early x-ray diffraction studies of muscle revealed spacings larger than the basic thick filament lattice spacing and led t...
Crystallisation and characterisation of muscle proteins: a mini-review
Crystallisation and characterisation of muscle proteins: a mini-review
The techniques of X-ray protein crystallography, NMR and high-resolution cryo-electron microscopy have all been used to de...
Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments
Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments
Myosin binding protein C (MyBP-C) is an accessory protein of the thick filament in vertebrate cardiac muscle arranged over...
John Squire and the myosin thick filament structure in muscle
John Squire and the myosin thick filament structure in muscle
The structure of the thin, actin-containing filament of muscle is both highly conserved across a broad range of muscle typ...
Lessons learned from comparative and extreme physiology
Lessons learned from comparative and extreme physiology
Bernard (1984), the founder of modern experimental physiology, and later Krogh (1929) and Kre...
Six weeks of high-load resistance and low-load blood flow restricted training increase Na/K-ATPase sub-units α2 and β1 equally, but does not alter ClC-1 abundance in untrained human skeletal muscle
Six weeks of high-load resistance and low-load blood flow restricted training increase Na/K-ATPase sub-units α2 and β1 equally, but does not alter ClC-1 abundance in untrained human skeletal muscle
Contractile function of skeletal muscle relies on the ability of muscle fibers to trigger and propagate action potentials ...
Xenogeneic transplantation of mitochondria induces muscle regeneration in an in vivo rat model of dexamethasone-induced atrophy
Xenogeneic transplantation of mitochondria induces muscle regeneration in an in vivo rat model of dexamethasone-induced atrophy
Muscle atrophy significantly impairs health and quality of life; however, there is still no cure. Recently, the possibilit...
Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging
Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging
Nestin is a unique intermediate filament expressed for a short period in the developing heart. It was also documented in s...
Adaptations for extremely high muscular power output: why do muscles that operate at intermediate cycle frequencies generate the highest powers?
Adaptations for extremely high muscular power output: why do muscles that operate at intermediate cycle frequencies generate the highest powers?
The pectoralis muscles of the blue-breasted quail Coturnix chinensis generate the highest power output over a contraction ...
Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5
Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5
Nonsense mediated mRNA decay (NMD) is a highly conserved RNA quality control system, which can specifically clear abnormal...
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders of skeletal muscle causing weakness and disability. Uti...
Determinants of maximal oxygen consumption
Determinants of maximal oxygen consumption
This article lays out the determinants of maximal O2 consumption (VO2max) achieved during high intensity endurance exercis...
The predominant stride-frequency for routine swimming in catsharks (Scyliorhinus canicula) generates high power at high efficiency in the red musculature
The predominant stride-frequency for routine swimming in catsharks (Scyliorhinus canicula) generates high power at high efficiency in the red musculature
Videos of free swimming of catsharks (Scyliorhinus canicula) were analysed to give values of swimming speed (units: FL (fi...
Compensatory hemodynamic changes in response to central hypovolemia in humans: lower body negative pressure: updates and perspectives
Compensatory hemodynamic changes in response to central hypovolemia in humans: lower body negative pressure: updates and perspectives
Central hypovolemia is accompanied by hemodynamic compensatory responses. Understanding the complex systemic compensatory ...
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