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APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain paren...
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with ...
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is pr...
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Parkinson’s disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the pro...
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption o...
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated wi...
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neu...
Alzheimer’s genes in microglia: a risk worth investigating
Alzheimer’s genes in microglia: a risk worth investigating
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is s...
Donald Lowell Price, M.D. In memoriam
Donald Lowell Price, M.D. In memoriam
Molecu...
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal ...
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the ...
Altered plasma protein profiles in genetic FTD – a GENFI study
Altered plasma protein profiles in genetic FTD – a GENFI study
Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to...
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-pro...
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highli...
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD)....
α-Synuclein serine129 phosphorylation – the physiology of pathology
α-Synuclein serine129 phosphorylation – the physiology of pathology
The study that found phospho-serine129 in the Parkinson’s-linked protein alpha-synuclein over two decades ago proposed a p...
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper an...
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, et al. Cerebral Hemorrhage after passive anti-a...
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also ob...
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, et al. Preclinical and randomized clinical evaluation of ...
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs cont...
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglia...
Correction: Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
Correction: Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, 03080, Republic of KoreaJihoon...
TDP-43 pathology is associated with increased tau burdens and seeding
TDP-43 pathology is associated with increased tau burdens and seeding
Most Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathologi...
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps
Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occu...
Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
The optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of man...
News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023
News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023
Two AAAs show clear modest benefit in relatively short trials. The most important side effect is ARIA [9], and, while ARIA...
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemic...
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