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Rucaparib induces mitochondrial fragmentation and apoptosis in prostate cancer cells by targeting Drp1
Rucaparib induces mitochondrial fragmentation and apoptosis in prostate cancer cells by targeting Drp1
Mitochondrial dynamics, particularly the balance between fission and fusion, are critical in regulating cellular metabolis...
A phase 1b/2 study of intermittent talazoparib plus temozolomide in patients with metastatic castration-resistant prostate cancer and no mutations in DNA damage response genes
A phase 1b/2 study of intermittent talazoparib plus temozolomide in patients with metastatic castration-resistant prostate cancer and no mutations in DNA damage response genes
As monotherapy, PARP inhibitors have little cytotoxic effect in tumors without homologous recombinant repair (HRR) alterat...
Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation
Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation
Serine metabolism plays a pivotal role in supporting the rapid proliferation of tumor cells, with PHGDH recognized as a ke...
Advanced strategies to overcome multidrug resistance in cancer therapy: progress in P-glycoprotein inhibitors, drug delivery, and personalized medicine
Advanced strategies to overcome multidrug resistance in cancer therapy: progress in P-glycoprotein inhibitors, drug delivery, and personalized medicine
Multidrug resistance (MDR) appears to be a major challenge in cancer treatment, frequently leading to suboptimal clinical ...
Association of different approvals with Chinese Society of Clinical Oncology recommendation levels for solid tumor drugs: a cross-sectional analysis
Association of different approvals with Chinese Society of Clinical Oncology recommendation levels for solid tumor drugs: a cross-sectional analysis
In China, many solid tumor drugs have been approved via the accelerated approval (AA) pathway. We extracted data regarding...
Targeting the TRIB3–MYC axis in cancer: mechanistic insights and therapeutic disruption strategies
Targeting the TRIB3–MYC axis in cancer: mechanistic insights and therapeutic disruption strategies
The oncogenic transcription factor MYC drives proliferation, metabolism, and therapy resistance in the majority of human c...
Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventions
Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventions
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is the first-line regulator of a plethora of c...
Safety and efficacy of semi-dose venetoclax plus azacitidine in unfit acute myeloid leukemia patients in China: a real-world single-center study
Safety and efficacy of semi-dose venetoclax plus azacitidine in unfit acute myeloid leukemia patients in China: a real-world single-center study
Acute myeloid leukemia (AML) carries a poor prognosis in elderly or medically unfit patients, with median overall survival...
Evaluation of the anti-leukemia activity and underlying mechanisms of the novel perinucleolar compartment inhibitor CTI-2 in acute myeloid leukemia
Evaluation of the anti-leukemia activity and underlying mechanisms of the novel perinucleolar compartment inhibitor CTI-2 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant clonal hematological tumor originating from immature myeloid cells and is the ...
Direct functional HOXA9/DNA-binding competitors versus epigenetic inhibitors of HOXA9 expression on cell proliferation, death and differentiation processes in the model of MLL-rearranged acute myeloid leukemia
Direct functional HOXA9/DNA-binding competitors versus epigenetic inhibitors of HOXA9 expression on cell proliferation, death and differentiation processes in the model of MLL-rearranged acute myeloid leukemia
Recent progress in cancer treatment has led to the development of advanced therapies targeting specific oncogenic drivers,...
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells
Ovarian cancer remains one of the most lethal gynecologic malignancies, largely due to high recurrence rates and treatment...
Anti-CD47 tri-specific killer engager enhances NK cell cytotoxicity against lung cancer
Anti-CD47 tri-specific killer engager enhances NK cell cytotoxicity against lung cancer
Lung cancer remains the leading cause of cancer-related deaths worldwide, with immune evasion posing a major therapeutic c...
Clinical characteristics, treatment and prognosis of pembrolizumab induced myocarditis
Clinical characteristics, treatment and prognosis of pembrolizumab induced myocarditis
To explore the regularity and clinical characteristics of pembrolizumab induced myocarditis, and to provide a reference fo...
The multifaceted role of KIF15 in cancer progression and therapy
The multifaceted role of KIF15 in cancer progression and therapy
Kinesin family member 15 (KIF15), a kinesin superfamily motor protein, is known to be involved in mitotic spindle formatio...
Phase 1/2, open-label study of oral bacterial supplementation (EDP1503) plus pembrolizumab in participants with advanced or metastatic microsatellite-stable colorectal cancer, triple-negative breast cancer, and checkpoint inhibitor–relapsed tumors
Phase 1/2, open-label study of oral bacterial supplementation (EDP1503) plus pembrolizumab in participants with advanced or metastatic microsatellite-stable colorectal cancer, triple-negative breast cancer, and checkpoint inhibitor–relapsed tumors
We report a phase 1/2 study evaluating EDP1503 (capsule containing Bifidobacterium animalis lactis) ± pem...
Tackling tumor hypoxia: advances in breaking the oncogenic HIF-1α–p300/CBP alliance
Tackling tumor hypoxia: advances in breaking the oncogenic HIF-1α–p300/CBP alliance
The ability of tumor cells to survive under low-oxygen conditions is largely attributed to the hypoxia-inducible factor-1 ...
Clinical potential of antibody–drug conjugates in early-phase clinical trials for late-line treatment of advanced solid tumors
Clinical potential of antibody–drug conjugates in early-phase clinical trials for late-line treatment of advanced solid tumors
Recently, comprehensive genomic profiling (CGP)-matched therapy and antibody–drug conjugates (ADCs) have garnered in...
Assessing the risks and benefits of investigational new drugs in adult phase-I oncology trials in China, 2013–2021
Assessing the risks and benefits of investigational new drugs in adult phase-I oncology trials in China, 2013–2021
Previous research shows that the benefits of phase-I oncology trials increased from 5 to 18% between 2000 and 2019 globall...
Beyond the obvious: targeting the SLC transportome and non-canonical drug transport mechanisms in cancer therapy
Beyond the obvious: targeting the SLC transportome and non-canonical drug transport mechanisms in cancer therapy
The solute carrier (SLC) superfamily comprises a broad array of membrane-bound transport proteins that are integral to the...
Cost-Effectiveness Analyses of Adolescent- and Young-Adult-Focused HIV Interventions Incorporating HIV Transmission: a Scoping Review of Modeling Methods and Proposed Guidance
Cost-Effectiveness Analyses of Adolescent- and Young-Adult-Focused HIV Interventions Incorporating HIV Transmission: a Scoping Review of Modeling Methods and Proposed Guidance
Adolescents and young adults (AYA) are disproportionately affected by human immunodeficiency virus (HIV) globally, with hi...
Exploratory Cost-Effectiveness of a Novel Bioprosthetic Valve for Surgical Aortic Valve Replacement in Spain
Exploratory Cost-Effectiveness of a Novel Bioprosthetic Valve for Surgical Aortic Valve Replacement in Spain
Limited information is available regarding the impact of valve choice for patients with aortic stenosis (AS) undergoing su...
Adjusting Health State Utility Values for Multiple Conditions: Real-World EQ-5D-3L Data Modeling in Brazil
Adjusting Health State Utility Values for Multiple Conditions: Real-World EQ-5D-3L Data Modeling in Brazil
Decision analytical models are typically included in health economic evaluations to represent clinical pathways and enable...
An Enhanced Retention Strategy to Prevent the Vertical Transmission of HIV in Uganda: A Budget Impact Analysis
An Enhanced Retention Strategy to Prevent the Vertical Transmission of HIV in Uganda: A Budget Impact Analysis
Novel retention strategies have the potential to reduce vertical transmission of HIV and improve patient outcomes for wome...
Real-World Analysis of Healthcare Utilization, Treatment Patterns, and Economic Burden in Medicare Beneficiaries with Parkinson’s Disease: Implications by Levodopa Formulation and Disease Severity
Real-World Analysis of Healthcare Utilization, Treatment Patterns, and Economic Burden in Medicare Beneficiaries with Parkinson’s Disease: Implications by Levodopa Formulation and Disease Severity
This study aimed to evaluate healthcare utilization, costs, and treatment patterns of Medicare beneficiaries with Parkinso...
Cost-Effectiveness of the CADScor System in Low-Risk Patients Presenting to the Emergency Department with Chest Pain
Cost-Effectiveness of the CADScor System in Low-Risk Patients Presenting to the Emergency Department with Chest Pain
Studies have shown that up to 13% of patients presenting to the emergency department (ED) with low-risk chest pain receive...
Including Productivity as an Element to Reflect Value of the Treatment: A Systematic Review of Published Health Economic Evaluations
Including Productivity as an Element to Reflect Value of the Treatment: A Systematic Review of Published Health Economic Evaluations
Productivity is utilised inconsistently in value assessment and poses methodological and conceptual challenges for estimat...
Economic Evaluation of Lecanemab for Early Symptomatic Alzheimer's Disease in South Korea
Economic Evaluation of Lecanemab for Early Symptomatic Alzheimer's Disease in South Korea
Alzheimer's disease (AD) exerts a considerable economic burden on South Korea's aging population. Lecanemab, an am...
Cost-Effectiveness of an Insertable Cardiac Arrhythmia Monitor after Non-ST-Elevation Myocardial Infarction in the UK
Cost-Effectiveness of an Insertable Cardiac Arrhythmia Monitor after Non-ST-Elevation Myocardial Infarction in the UK
Patients surviving a non-ST-elevation myocardial infarction (NSTEMI) have an elevated risk of future major adverse cardiov...
Economic Evaluation of Treatment With Trastuzumab Deruxtecan for HER2-Low Advanced or Metastatic Breast Cancer in Previously Treated Patients
Economic Evaluation of Treatment With Trastuzumab Deruxtecan for HER2-Low Advanced or Metastatic Breast Cancer in Previously Treated Patients
This study evaluates the efficiency and budgetary impact of trastuzumab deruxtecan (T-DXd) compared with standard therapy ...
Identifying Potential Gaps in Care for Patients with Higher-Risk Myelodysplastic Syndromes in a Large US Health System
Identifying Potential Gaps in Care for Patients with Higher-Risk Myelodysplastic Syndromes in a Large US Health System
Higher-risk myelodysplastic syndromes (HR-MDS) may be difficult to diagnose because patients present with nonspecific sign...
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