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Rathke’s cleft cyst: From history to molecular genetics
Rathke’s cleft cyst: From history to molecular genetics
A Rathke’s cleft cyst (RCC) is a remnant of the embryologic Rathke’s pouch and a common pituitary lesion. A tr...
Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?
Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?
People with type 2 diabetes (T2D) have a 2–3-time higher risk of developing sarcopenia, a musculoskeletal disease ma...
Melatonin administration on bone properties of animals under hypoestrogenism: A systematic review
Melatonin administration on bone properties of animals under hypoestrogenism: A systematic review
Purpose: Hypoestrogenism is associated with loss of bone mass and strength. Melatonin has become a strategy due to its act...
Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved
Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved
Obesity and type-2 diabetes mellitus (T2DM) are interrelated metabolic disorders primarily driven by overnutrition and phy...
Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries
Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries
Acromegaly is a rare condition, and often diagnosis is delayed by several years, for most patients. Acromegaly is characte...
Mention to Prof. Andrew V. Schally
Mention to Prof. Andrew V. Schally
1.1 GHRH: The first 50 yearsHalf a century has passed since the discovery of growth hormone-releasing hormone (GHRH), a gr...
Insulin icodec: A novel once-weekly formulation for the treatment of type 1 and type 2 diabetes mellitus
Insulin icodec: A novel once-weekly formulation for the treatment of type 1 and type 2 diabetes mellitus
Insulin icodec is a novel once-weekly basal insulin analog subcutaneous injection seeking approval by the United States Fo...
Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions
Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions
Neuroendocrine tumors (NET) are frequently associated with glycemic disorders, such as prediabetes or diabetes, which may ...
Ectopic GHRH production: revisiting a rare cause of acromegaly
Ectopic GHRH production: revisiting a rare cause of acromegaly
Growth Hormone-Releasing Hormone (GHRH) is a hypothalamic hormone that stimulates GH secretion by the anterior pituitary g...
Childhood obesity: The threatening apprentice of the adiposity empire
Childhood obesity: The threatening apprentice of the adiposity empire
Childhood obesity is a global health problem, with its prevalence having tripled since 1975. The increase in its prevalenc...
The science of bioelectrical impedance-derived phase angle: insights from body composition in youth
The science of bioelectrical impedance-derived phase angle: insights from body composition in youth
Despite bioelectrical impedance analysis (BIA)-derived phase angle (PhA) being recognized as a global marker of health, re...
Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis
Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis
The purpose of our study was to evaluate the efficacy and safety of partial adrenalectomy (PA) in the management ...
Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity
Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity
The prevalence of obesity is rising around the world, as the number of subjects dieting and experiencing weight loss follo...
Hypothalamic control of heart rate and body temperature by thyroid hormones
Hypothalamic control of heart rate and body temperature by thyroid hormones
As evidenced by the clinical symptoms in hyper- or hypothyroidism, thyroid hormones have strong effects on cardiovascular ...
New drugs for the treatment of obesity: do we need approaches to preserve muscle mass?
New drugs for the treatment of obesity: do we need approaches to preserve muscle mass?
The development of drugs targeting Nutrient Stimulated Hormone receptors has ushered in a dramatic change in our approach ...
Hypopituitarism in non-neuroendocrine pituitary tumors: a systematic review
Hypopituitarism in non-neuroendocrine pituitary tumors: a systematic review
The existing evidence on pituitary function impairment in non-neuroendocrine pituitary tumors (non-PitNETs) is limited and...
Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity
Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity
Across the spectrum of weight regain, ranging from cachexia rehabilitation and catch-up growth to obesity relapse, the rec...
Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review
Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review
Oral hormone replacement therapy has been and continues to be the cornerstone of adrenocortical insufficiency management. ...
Continuous glucose monitoring in patients with inherited metabolic disorders at risk for Hypoglycemia and Nutritional implications
Continuous glucose monitoring in patients with inherited metabolic disorders at risk for Hypoglycemia and Nutritional implications
Managing Inherited Metabolic Disorders (IMDs) at risk for hypoglycemia, such as Glycogen Storage Diseases (GSDs), Heredita...
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Diabetes has arisen as a noteworthy global health issue, marked by escalating incidence and mortality rates. Insulin, cruc...
Growth hormone – releasing hormone in the immune system
Growth hormone – releasing hormone in the immune system
GHRH is a neuropeptide associated with a diverse variety of activities in human physiology and immune responses. The prese...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has ...
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
Acute myeloid leukemia (AML) is the most aggressive and prevalent form of leukemia in adults. The gold-standard interventi...
The molecular basis of hypoprolactinaemia
The molecular basis of hypoprolactinaemia
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency ...
Growth hormone-releasing hormone and cancer
Growth hormone-releasing hormone and cancer
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of gr...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
GHRH and its analogues in central nervous system diseases
GHRH and its analogues in central nervous system diseases
Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hor...
Prolactin: structure, receptors, and functions
Prolactin: structure, receptors, and functions
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also ...
Role of HOXA10 in pathologies of the endometrium
Role of HOXA10 in pathologies of the endometrium
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implan...
GHRH and the prostate
GHRH and the prostate
In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it ...
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