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IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
Natural killer (NK) cells are essential for controlling tumor metastasis, but their protective capacity diminishes when en...
pDCs drive immunopathology by sensing oxidized mitochondrial DNA
pDCs drive immunopathology by sensing oxidized mitochondrial DNA
Plasmacytoid dendritic cells are known for their ability to produce large amounts of type I interferons, which can contrib...
Gene–environment interactions shape the host–microbial interface in inflammatory bowel disease
Gene–environment interactions shape the host–microbial interface in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex, multifactorial inflammatory disorder of the gut characterized by an imbalan...
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation
Stress-induced oxidized mitochondrial DNA (Ox-mtDNA) fragments enter the cytoplasm, activating the NLRP3 inflammasome and ...
Peripheral infection wires T cells in the brain
Peripheral infection wires T cells in the brain
Research shows that previous peripheral microbial encounters can prime the entry of memory T cells into the brain, reshapi...
CARD11 signaling regulates CD8+ T cell tumoricidal function
CARD11 signaling regulates CD8+ T cell tumoricidal function
Chronic stimulation in the tumor microenvironment can induce exhausted CD8+ T (Tex) cells that have limited tumoricidal ac...
Portal macrophages maintain liver homeostasis
Portal macrophages maintain liver homeostasis
The liver portal area has emerged as an important region controlling liver homeostasis and diseases. Tissue macrophages in...
Neuroprotective liver portal area macrophages attenuate hepatic inflammation
Neuroprotective liver portal area macrophages attenuate hepatic inflammation
Tissue macrophages have an important role in the maintenance of liver homeostasis, and their functions are closely related...
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The mos...
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author notesThese authors contributed equally: Marko Šestan, Inga Kavazović.Authors and AffiliationsDepartment of Histolog...
B cells infiltrate cutaneous T cell lymphomas
B cells infiltrate cutaneous T cell lymphomas
Cutaneous T cell lymphoma is a rare, difficult to diagnose malignancy of T cells. Malignant T cells, together with populat...
The diverse roles of neutrophils from protection to pathogenesis
The diverse roles of neutrophils from protection to pathogenesis
Neutrophil granulocytes are the most abundant leukocytes in the blood and constitute a critical arm of innate immunity. Th...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also...
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
The type 2 cytokines, interleukin (IL)-4, IL-13 and IL-5 reside within a multigene cluster. Both innate (ILC2) and adaptiv...
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an o...
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
Vaccination with self- and foreign peptides induces weak and strong expansion of antigen-specific CD4+ T cells, respective...
A humanized mouse that mounts specific and mature antibody and autoantibody responses
A humanized mouse that mounts specific and mature antibody and autoantibody responses
We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse n...
T cell dysfunction and therapeutic intervention in cancer
T cell dysfunction and therapeutic intervention in cancer
Recent advances in immunotherapy have affirmed the curative potential of T cell-based approaches for treating relapsed and...
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting early in life has been proposed to influence the risk of infection by influenza viruses later on ...
Dietary glutamine supports mucosal germinal center B cell lymphomas
Dietary glutamine supports mucosal germinal center B cell lymphomas
The G protein Gα13 is frequently lost in germinal center (GC) B cell-derived lymphomas. Mice that lack Gα13 exhi...
Recasting resistance to Mycobacterium tuberculosis
Recasting resistance to Mycobacterium tuberculosis
Why some individuals ‘resist’ infection with Mycobacterium tuberculosis (Mtb) has been an enigma. Enriched T c...
Directing risky traffic in B cells with TNIP1
Directing risky traffic in B cells with TNIP1
TNIP1, a previously identified risk factor for autoimmunity, regulates mitochondrial autophagosomal trafficking. Missense ...
An intestinal TH17 cell-derived subset can initiate cancer
An intestinal TH17 cell-derived subset can initiate cancer
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, w...
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Whole-exome sequencing of two unrelated kindreds with systemic autoimmune disease featuring antinuclear antibodies with Ig...
International nomenclature guidelines for the IL-1 family of cytokines and receptors
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAJoseph M. Gaballa, Jesper Falkesgaa...
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized mul...
Mapping human hematopoiesis
Mapping human hematopoiesis
Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into h...
cGAS meets its demise in the nucleus
cGAS meets its demise in the nucleus
DNA sensing for the purposes of innate immunity is tricky when the DNA sensor can easily become stuck on chromosomes durin...
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell
These authors contributed equally: Yulong Gao, Fernando Souza-Fonseca-Guimaraes.Immunology in Cancer and Infection, QIMR B...
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cell...
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