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A humanized mouse that mounts specific and mature antibody and autoantibody responses
A humanized mouse that mounts specific and mature antibody and autoantibody responses
We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse n...
T cell dysfunction and therapeutic intervention in cancer
T cell dysfunction and therapeutic intervention in cancer
Recent advances in immunotherapy have affirmed the curative potential of T cell-based approaches for treating relapsed and...
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting early in life has been proposed to influence the risk of infection by influenza viruses later on ...
Dietary glutamine supports mucosal germinal center B cell lymphomas
Dietary glutamine supports mucosal germinal center B cell lymphomas
The G protein Gα13 is frequently lost in germinal center (GC) B cell-derived lymphomas. Mice that lack Gα13 exhi...
Recasting resistance to Mycobacterium tuberculosis
Recasting resistance to Mycobacterium tuberculosis
Why some individuals ‘resist’ infection with Mycobacterium tuberculosis (Mtb) has been an enigma. Enriched T c...
Directing risky traffic in B cells with TNIP1
Directing risky traffic in B cells with TNIP1
TNIP1, a previously identified risk factor for autoimmunity, regulates mitochondrial autophagosomal trafficking. Missense ...
An intestinal TH17 cell-derived subset can initiate cancer
An intestinal TH17 cell-derived subset can initiate cancer
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, w...
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Whole-exome sequencing of two unrelated kindreds with systemic autoimmune disease featuring antinuclear antibodies with Ig...
International nomenclature guidelines for the IL-1 family of cytokines and receptors
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAJoseph M. Gaballa, Jesper Falkesgaa...
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized mul...
Mapping human hematopoiesis
Mapping human hematopoiesis
Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into h...
cGAS meets its demise in the nucleus
cGAS meets its demise in the nucleus
DNA sensing for the purposes of innate immunity is tricky when the DNA sensor can easily become stuck on chromosomes durin...
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell
These authors contributed equally: Yulong Gao, Fernando Souza-Fonseca-Guimaraes.Immunology in Cancer and Infection, QIMR B...
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cell...
Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains ev...
Thioredoxin is a metabolic rheostat controlling regulatory B cells
Thioredoxin is a metabolic rheostat controlling regulatory B cells
Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (Breg) cell differen...
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that det...
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require ...
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use ...
Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
John DaviesPresent address: Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USAChristian S. HinrichsP...
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previo...
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. How...
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms
Author notesWen ZhouPresent address: BillionToOne, Menlo Park, CA, USAFan GaoPresent address: Lyterian Therapeutics, South...
Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement
The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced r...
Cancer immunology leads the way
Cancer immunology research is diverse, uses cutting-edge technologies and continues to excite with its constantly evolving...
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen re...
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consumin...
A second-generation M1-polarized CAR macrophage with antitumor efficacy
A second-generation M1-polarized CAR macrophage with antitumor efficacy
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have al...
The immunometabolic ecosystem in cancer
The immunometabolic ecosystem in cancer
Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified me...
Forks in the road for CAR T and CAR NK cell cancer therapies
Forks in the road for CAR T and CAR NK cell cancer therapies
The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented long-term clearance of relapse/...
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