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Proteogenomics identifies anticancer targets
Discover the world’s best science and medicine | Nature.com
Chinese innovative drug R&D trends in 2024
Chinese innovative drug R&D trends in 2024
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Genome-editing medicinal products: the EMA perspective
Genome-editing medicinal products: the EMA perspective
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FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
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The landscape of small-molecule prodrugs
The landscape of small-molecule prodrugs
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which u...
Novel drug targets in 2023
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RNAi-based drug design: considerations and future directions
RNAi-based drug design: considerations and future directions
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming...
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
Top product forecasts for 2024
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Upcoming market catalysts in Q1 2024
Upcoming market catalysts in Q1 2024
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FDA approves first chikungunya vaccine
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PROTAC in clinic for autoimmune skin disease
PROTAC in clinic for autoimmune skin disease
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Gene therapy zeroes in on Parkinson disease brain circuits
Gene therapy zeroes in on Parkinson disease brain circuits
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FDA approves first-in-class AKT inhibitor
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A decade of HCV drugs
A decade of HCV drugs
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Antibodies achieve leptin balancing act
Antibodies achieve leptin balancing act
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γ-secretase inhibitor notches first approval
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De-risking rare disease acquisitions: a win–win–win for patients, biotech and investors
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tRNA therapeutics for genetic diseases
tRNA therapeutics for genetic diseases
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the t...
CAAR T cells to treat encephalitis
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A safer polyene antifungal
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USP30 inhibition protects dopaminergic neurons
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Open-science drug discovery for COVID-19
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Antibodies combat Gram-negative pathogen
Antibodies combat Gram-negative pathogen
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of...
Tailor made: the art of therapeutic mRNA design
Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly developing field in which the delivery of genetic information in the form of mRNA is us...
A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA a...
The renal cell carcinoma drug market
The renal cell carcinoma drug market
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Targeting synapse function and loss for treatment of neurodegenerative diseases
Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, t...
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