SCI Abstract

search
+
Understanding semaglutide action in the brain
Discover the world’s best science and medicine | Nature.com
Base editing tackles trinucleotide repeat diseases
Discover the world’s best science and medicine | Nature.com
Generative AI: a generation-defining shift for biopharma regulatory affairs
As biopharmaceutical companies face mounting pressure to accelerate development timelines and improve the speed and qualit...
Enhancing CAR-T cell efficacy through IFN ablation
Enhancing CAR-T cell efficacy through IFN ablation
Discover the world’s best science and medicine | Nature.com
A neonatal window for in vivo gene therapy in haematopoietic stem cells
A neonatal window for in vivo gene therapy in haematopoietic stem cells
Discover the world’s best science and medicine | Nature.com
Metabolites as agents and targets for cancer immunotherapy 
Metabolites as agents and targets for cancer immunotherapy 
The depletion or accumulation of metabolites in the tumour microenvironment is one of the hallmarks of cancer, but targeti...
FDA approves first factor XIIa inhibitor, for hereditary angioedema
Discover the world’s best science and medicine | Nature.com
Targeting the Hippo pathway in cancer
Targeting the Hippo pathway in cancer
The Hippo pathway is a highly conserved signalling network that controls tissue growth and cell fate, responding to physic...
Senescence as a therapeutic target in cancer and age-related diseases
Senescence as a therapeutic target in cancer and age-related diseases
Cellular senescence is a stress response that restrains the growth of aged, damaged or abnormal cells. Thus, senescence ha...
Targeting lysine acetylation readers and writers
Targeting lysine acetylation readers and writers
Lysine acetylation is a major post-translational modification in histones and other proteins that is catalysed by the R...
Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights
Author notesThese authors contributed equally: Dennis S. W. Lee, Olga L. Rojas.Authors and AffiliationsDepartment of Immun...
Proteogenomics identifies anticancer targets
Discover the world’s best science and medicine | Nature.com
Chinese innovative drug R&D trends in 2024
Chinese innovative drug R&D trends in 2024
Discover the world’s best science and medicine | Nature.com
Genome-editing medicinal products: the EMA perspective
Genome-editing medicinal products: the EMA perspective
Discover the world’s best science and medicine | Nature.com
FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
Discover the world’s best science and medicine | Nature.com
The landscape of small-molecule prodrugs
The landscape of small-molecule prodrugs
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which u...
Novel drug targets in 2023
Discover the world’s best science and medicine | Nature.com
RNAi-based drug design: considerations and future directions
RNAi-based drug design: considerations and future directions
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming...
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
Top product forecasts for 2024
Discover the world’s best science and medicine | Nature.com
Upcoming market catalysts in Q1 2024
Upcoming market catalysts in Q1 2024
Discover the world’s best science and medicine | Nature.com
FDA approves first chikungunya vaccine
Discover the world’s best science and medicine | Nature.com
PROTAC in clinic for autoimmune skin disease
PROTAC in clinic for autoimmune skin disease
Discover the world’s best science and medicine | Nature.com
Gene therapy zeroes in on Parkinson disease brain circuits
Gene therapy zeroes in on Parkinson disease brain circuits
Discover the world’s best science and medicine | Nature.com
FDA approves first-in-class AKT inhibitor
Discover the world’s best science and medicine | Nature.com
A decade of HCV drugs
A decade of HCV drugs
Discover the world’s best science and medicine | Nature.com
Antibodies achieve leptin balancing act
Antibodies achieve leptin balancing act
Discover the world’s best science and medicine | Nature.com
γ-secretase inhibitor notches first approval
Discover the world’s best science and medicine | Nature.com
De-risking rare disease acquisitions: a win–win–win for patients, biotech and investors
Discover the world’s best science and medicine | Nature.com
Load More
format_indent_increase