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Senescence as a therapeutic target in cancer and age-related diseases
Senescence as a therapeutic target in cancer and age-related diseases
Cellular senescence is a stress response that restrains the growth of aged, damaged or abnormal cells. Thus, senescence ha...
Targeting lysine acetylation readers and writers
Targeting lysine acetylation readers and writers
Lysine acetylation is a major post-translational modification in histones and other proteins that is catalysed by the R...
Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights
Author notesThese authors contributed equally: Dennis S. W. Lee, Olga L. Rojas.Authors and AffiliationsDepartment of Immun...
Proteogenomics identifies anticancer targets
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Chinese innovative drug R&D trends in 2024
Chinese innovative drug R&D trends in 2024
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Genome-editing medicinal products: the EMA perspective
Genome-editing medicinal products: the EMA perspective
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FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept
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The landscape of small-molecule prodrugs
The landscape of small-molecule prodrugs
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which u...
Novel drug targets in 2023
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RNAi-based drug design: considerations and future directions
RNAi-based drug design: considerations and future directions
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming...
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
Top product forecasts for 2024
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Upcoming market catalysts in Q1 2024
Upcoming market catalysts in Q1 2024
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FDA approves first chikungunya vaccine
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PROTAC in clinic for autoimmune skin disease
PROTAC in clinic for autoimmune skin disease
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Gene therapy zeroes in on Parkinson disease brain circuits
Gene therapy zeroes in on Parkinson disease brain circuits
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FDA approves first-in-class AKT inhibitor
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A decade of HCV drugs
A decade of HCV drugs
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Antibodies achieve leptin balancing act
Antibodies achieve leptin balancing act
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γ-secretase inhibitor notches first approval
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De-risking rare disease acquisitions: a win–win–win for patients, biotech and investors
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tRNA therapeutics for genetic diseases
tRNA therapeutics for genetic diseases
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the t...
CAAR T cells to treat encephalitis
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A safer polyene antifungal
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USP30 inhibition protects dopaminergic neurons
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Open-science drug discovery for COVID-19
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Antibodies combat Gram-negative pathogen
Antibodies combat Gram-negative pathogen
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of...
Tailor made: the art of therapeutic mRNA design
Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly developing field in which the delivery of genetic information in the form of mRNA is us...
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