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Antineoplastic Activity of Selected Cytotoxic Plants from the Kalahari
Antineoplastic Activity of Selected Cytotoxic Plants from the Kalahari
Plants are known to produce cytotoxic compounds, some of which are currently being used as chemotherapeutic agents for the...
Deciphering the Anti-metastatic Efficacy of Semi-purified Indigocarpan by Modulating Matrix Metalloproteinases and Promoting Cell Death
Deciphering the Anti-metastatic Efficacy of Semi-purified Indigocarpan by Modulating Matrix Metalloproteinases and Promoting Cell Death
Herbal medicine-based therapies are an essential trait for cancer treatment due to their competency and less side effects....
Seasonal Chemical Variation and Antidiabetic Activity of Major Compounds in Artemisia afra Infusions
Seasonal Chemical Variation and Antidiabetic Activity of Major Compounds in Artemisia afra Infusions
Artemisia afra Jacq. ex Willd., Asteraceae, is a very popular herbal medicine in Southern Africa and is mainly used in the...
Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by t...
A Novel Artemisinin-Derived Sesquiterpene from Bacopa gratioloides Volatile Oil by Sustainable and Enhanced Procedures
A Novel Artemisinin-Derived Sesquiterpene from Bacopa gratioloides Volatile Oil by Sustainable and Enhanced Procedures
Bacopa gratioloides (Cham.) Chodat & Hassl., Plantaginaceae, is an aquatic species underexplored and found in the ...
Detecting Phytoestrogens and Mammalian Estrogens in Blackcurrants (Ribes nigrum)
Detecting Phytoestrogens and Mammalian Estrogens in Blackcurrants (Ribes nigrum)
Phytoestrogens are estrogen-like compounds found in various plants. Menopausal women experience various menopausal symptom...
Lariciresinol Induces Apoptosis and Inhibits Migration-Invasion of Patient-Derived Hypertrophic Scar Fibroblasts via Preventing Accumulation of Collagen
Lariciresinol Induces Apoptosis and Inhibits Migration-Invasion of Patient-Derived Hypertrophic Scar Fibroblasts via Preventing Accumulation of Collagen
The hypertrophic scar is a pathological condition characterized by excessive fibrosis of the skin, which is frequently ref...
In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside...
Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Tricin is a flavonoid that occurs in monocotyledonous plants and exhibits a broad pharmacological spectrum, including anti...
Inhibition of Human CYP1A1/A2 by a Hydroalcoholic Extract and Its Neolignan Constituents from Piper rivinoides
Inhibition of Human CYP1A1/A2 by a Hydroalcoholic Extract and Its Neolignan Constituents from Piper rivinoides
Lignans and neolignans, commonly found in plants, are generally composed of two phenylpropane (C6-C3) units with a marked ...
Triticum aestivum Octacosanol, a Potential Inhibitor of PCSK9 in Fat Diet–Induced Hypercholesteromia
Triticum aestivum Octacosanol, a Potential Inhibitor of PCSK9 in Fat Diet–Induced Hypercholesteromia
Proprotein convertase subtilisin-like kexin type 9 (PCSK9) is a circulating serine protease that promotes the degradation ...
Alisol B 23-Acetate Affects a Podocyte Injury Model by Inhibiting PI3K/AKT/mTOR Signaling
Alisol B 23-Acetate Affects a Podocyte Injury Model by Inhibiting PI3K/AKT/mTOR Signaling
Diabetic nephropathy is the leading cause of impaired renal function. Podocyte injury is a crucial factor during the patho...
Effects of Spermidine Macrocyclic Alkaloids on the Expression of Amyloid β-Peptide in SH-SY5Y Cells via Autophagy
Effects of Spermidine Macrocyclic Alkaloids on the Expression of Amyloid β-Peptide in SH-SY5Y Cells via Autophagy
Three macrocyclic polyamine alkaloids with a 13-membered ring, named celafurine, celacarfurine, and celabenzine, isolated ...
Pharmacokinetic Study of Tilianin After Oral Administration in Wistar Rats by HPLC
Pharmacokinetic Study of Tilianin After Oral Administration in Wistar Rats by HPLC
Tilianin was obtained from the medicinal plant Agastache mexicana (Kunth) Lint & Epling, Lamiaceae, a compound tha...
Cytotoxicity of Salvigenin from Asterohyptis stellulata in Combination with Clinical Drugs Against Colorectal Cancer
Cytotoxicity of Salvigenin from Asterohyptis stellulata in Combination with Clinical Drugs Against Colorectal Cancer
Flavonoids, abundant polyphenols in various plant-based sources, exhibit diverse health benefits, particularly in cancer p...
Neuroprotective Effects of Hippeastrum elegans Extract: Anticholinesterase Effect In Silico and In Vivo Studies in the Scopolamine-Induced Memory Deficits Model in Rat
Neuroprotective Effects of Hippeastrum elegans Extract: Anticholinesterase Effect In Silico and In Vivo Studies in the Scopolamine-Induced Memory Deficits Model in Rat
Alzheimer’s disease is a chronic and progressive neurodegenerative disease that causes severe cognitive decline and ...
Anti-asthmatic Substances in the Chinese Herbal Formulation Huagai San Based on In Vitro and In Vivo Analysis and Network Pharmacology
Anti-asthmatic Substances in the Chinese Herbal Formulation Huagai San Based on In Vitro and In Vivo Analysis and Network Pharmacology
“Huagai san,” a Chinese classical herbal formulation, has been used for nearly 50 years to treat vari...
Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells
Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells
Chemoresistance has emerged as a critical barrier in the treatment of lung cancer. The recently discovered DNA repair enzy...
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Gestational diabetes mellitus is a condition of glucose intolerance that occurs only in pregnant women. Paeoniflorin was r...
Anti-inflammatory, Radical-Scavenging, and Chelating Activities of Nor-Triterpenes from Galphimia Species
Anti-inflammatory, Radical-Scavenging, and Chelating Activities of Nor-Triterpenes from Galphimia Species
Anti-inflammatory and radical-scavenging activities of the methanolic extract from the leaves of Galphimia spp. collected ...
Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line
Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line
Dengue fever is caused by the Aedes mosquito-borne dengue virus, which is a global threat with 400 million cases reported ...
Nitric Oxide Inhibitors from the Stem Bark of Biancaea decapetala: An In Vitro and In Silico Study
Nitric Oxide Inhibitors from the Stem Bark of Biancaea decapetala: An In Vitro and In Silico Study
This study presents the anti-inflammatory potential of compounds isolated from the stem bark of Biancaea decapetala (Roth)...
Isoflavone-Rich Extract of Trifolium resupinatum: Anti-obesity Attributes with In Silico Investigation of Its Constituents
Isoflavone-Rich Extract of Trifolium resupinatum: Anti-obesity Attributes with In Silico Investigation of Its Constituents
Trifolium resupinatum L., Fabaceae, aqueous methanol leaf extract was selected to mitigate some obesity-associated risk fa...
Resveratrol Improves Mechanical Allodynia and Inflammation: Focus on Sex Differences in Rats
Resveratrol Improves Mechanical Allodynia and Inflammation: Focus on Sex Differences in Rats
Inflammatory pain is a complex phenomenon arising from various etiological factors, resulting in diverse symptoms that can...
Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer
Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer
Triple-negative breast cancer stands out as the most formidable subtype of breast cancer. Currently, there is a lack of sp...
Anti HSV-1 Activity of Cistus laurifolius and Development of Antiviral Herbal Lip Balm
Anti HSV-1 Activity of Cistus laurifolius and Development of Antiviral Herbal Lip Balm
Cistus laurifolius L., Cistaceae, has long been used for traditional treatments against various skin diseases in Turkey. T...
Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by Bothrops jararaca Snake Venom in Mice
Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by Bothrops jararaca Snake Venom in Mice
Snakebites are considered a neglected tropical disease in Brazil and 70% of cases of envenomation are attributed to the ge...
Anti-inflammatory and Antioxidant Activity of Eugenial D from Eugenia astringens
Anti-inflammatory and Antioxidant Activity of Eugenial D from Eugenia astringens
Eugenia astringens Cambess. (syn. Eugenia umbelliflora O.Berg), Myrtaceae, is a plant widely used in the Brazilian traditi...
Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorpti...
Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage
Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage
Tropical black sage (Varronia curassavica Jacq., Cordiaceae) is a species native to ecosystems subject to strong anthropic...
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