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Smart biodegradable hydrogels: Drug-delivery platforms for treatment of chronic ophthalmic diseases affecting the back of the eye
Smart biodegradable hydrogels: Drug-delivery platforms for treatment of chronic ophthalmic diseases affecting the back of the eye
The growing incidence of chronic ophthalmic diseases reported in developed countries in recent decades is mainly due to in...
Near-infrared imaging of in vivo performance of orally administered solid forms to rats: Feasibility study with indocyanine green
Near-infrared imaging of in vivo performance of orally administered solid forms to rats: Feasibility study with indocyanine green
Solid formulations, such as tablets and capsules, undergo disintegration after administration as a function of formulation...
Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor
Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor
Multidrug resistance (MDR) is a major factor contributing to the failure of cancer therapy and is a public health issue of...
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
The two anti-epidermal growth factor receptor monoclonal antibodies (mAbs) cetuximab and panitumumab are the pillars for t...
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
The design of nanocapsules with a controlled architecture remains a major scientific and technological objective to this d...
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
The interactions of oral drugs with the complex environment of the gastrointestinal tract (GIT) may cause issues with drug...
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
The peptidyl-prolyl cis/trans isomerase Pin1 positively regulates numerous cancer-driving pathways, and it is overexpresse...
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Microneedles (MNs) have emerged as a simple technology that overcame several obstacles of the conventional drug delivery s...
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
Ischemic heart disease is a serious threat to human health and one of the leading causes of death worldwide (Nowbar et al....
Enhancing osteosarcoma therapy through aluminium hydroxide nanosheets-enabled macrophage modulation
Enhancing osteosarcoma therapy through aluminium hydroxide nanosheets-enabled macrophage modulation
Osteosarcoma is the most common primary bone cancer, manifesting in the distal femur with hallmarks such as pain and bone ...
Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis in vitro and in vivo models
Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis in vitro and in vivo models
Pulmonary diseases have emerged as a public health burden due to poor prognosis and inefficient clinical approaches in pas...
Graphene quantum dots based on cannabis seeds for efficient wound healing in a mouse incisional wound model: Link with stress and neurobehavioral effect
Graphene quantum dots based on cannabis seeds for efficient wound healing in a mouse incisional wound model: Link with stress and neurobehavioral effect
Wound repair is a worldwide medical issue implicating a number of highly controlled and complex reactions triggered by tis...
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma
Galangin (Gal) is a natural plant flavonoid. More and more evidence shows that Gal can achieve anti-tumor effects by regul...
Cylindrical granules in the development of mesalazine solid formulations (Ⅱ): The contribution of high aspect ratio to favorable tabletability
Cylindrical granules in the development of mesalazine solid formulations (Ⅱ): The contribution of high aspect ratio to favorable tabletability
Tablets are the most widespread dosage form because of low production cost, convenient administration, good patient compli...
Fe3+ mediated shikonin and PPA coloaded liposomes induce robust immunogenic cell death by integrating ROS enhancement and GSH depletion
Fe3+ mediated shikonin and PPA coloaded liposomes induce robust immunogenic cell death by integrating ROS enhancement and GSH depletion
Reactive oxygen species (ROS) are byproducts of cell metabolism produced by mitochondria and play a role in various physio...
Lyophilization enhances the stability of Panax notoginseng total saponins-loaded transfersomes without adverse effects on ex vivo/in vivo skin permeation
Lyophilization enhances the stability of Panax notoginseng total saponins-loaded transfersomes without adverse effects on ex vivo/in vivo skin permeation
The Chinese medicine Panax notoginseng (sanqi) is the dry root and rhizome of the Araliaceae plant Panax notoginseng (Burk...
Engineered exosomes mediated targeted delivery of neuroprotective peptide NR2B9c for the treatment of traumatic brain injury
Engineered exosomes mediated targeted delivery of neuroprotective peptide NR2B9c for the treatment of traumatic brain injury
Innovative techniques for delivering therapeutic macromolecules to the brain cells is of considerable interest in biomedic...
Rubropunctatin-silver composite nanoliposomes for eradicating Helicobacter pylori in vitro and in vivo
Rubropunctatin-silver composite nanoliposomes for eradicating Helicobacter pylori in vitro and in vivo
Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative microaerobic bacterium that colonizes the human gastric e...
Worsened punch sticking by external lubrication with magnesium stearate
Worsened punch sticking by external lubrication with magnesium stearate
The tablet has been widely used in drug delivery due to its physical and chemical stability, low manufacturing cost, and g...
Pulmonary administration of tetrandrine loaded Zinc-Alginate nanogels attenuates pulmonary fibrosis in rats
Pulmonary administration of tetrandrine loaded Zinc-Alginate nanogels attenuates pulmonary fibrosis in rats
Pulmonary fibrosis is a progressive pathological change of lung tissues, (Moss et al., 2022) which means the deposition of...
Targeted delivery of genistein for pancreatic cancer treatment using hyaluronic-coated cubosomes bioactivated with frankincense oil
Targeted delivery of genistein for pancreatic cancer treatment using hyaluronic-coated cubosomes bioactivated with frankincense oil
Pancreatic cancer is one of the deadliest malignancies worldwide, with a 9 % estimated 5-year relative survival rate (Lamb...
What to consider for successful administration of oral liquids via enteral feeding tubes? a case study with paediatric ibuprofen suspensions
What to consider for successful administration of oral liquids via enteral feeding tubes? a case study with paediatric ibuprofen suspensions
The swallowing process is an essential prerequisite for the oral supply of calories and nutrients, and thus also for a hea...
3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the treatment of inflammatory bowel disease
3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the treatment of inflammatory bowel disease
KeywordsFused deposition modelingHot-melt extrusionRectal administrationInfill densityPersonalized medicineAbbreviationsPS...
In situ process analytical technology for real time viable cell density and cell viability during live-virus vaccine production
In situ process analytical technology for real time viable cell density and cell viability during live-virus vaccine production
Upstream process development and robust analytical characterization of bioreactor cell culture processes are key to the su...
A nanocomposite hydrogel for co-delivery of multiple anti-biofilm therapeutics to enhance the treatment of bacterial biofilm-related infections
A nanocomposite hydrogel for co-delivery of multiple anti-biofilm therapeutics to enhance the treatment of bacterial biofilm-related infections
Bacterial biofilm-related infections are a leading cause of delayed healing in chronic wounds. Within biofilms, bacteria a...
In-vitro and in-vivo assessment of pH-responsive core–shell nanocarrier system for sequential delivery of methotrexate and 5-fluorouracil for the treatment of breast cancer
In-vitro and in-vivo assessment of pH-responsive core–shell nanocarrier system for sequential delivery of methotrexate and 5-fluorouracil for the treatment of breast cancer
The profound enhancement of cancer chemotherapy involves the use of synergistically active chemotherapeutic combinations. ...
Novel liposomal glatiramer acetate: Preparation and immunomodulatory evaluation in murine model of multiple sclerosis
Novel liposomal glatiramer acetate: Preparation and immunomodulatory evaluation in murine model of multiple sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), which is lymphocyte-de...
Corrigendum to “Design, optimization and pharmacokinetic evaluation of PLGA phosphatidylcholine hybrid nanoparticles of triamcinolone acetonide loaded in situ gel for topical ocular delivery” [Int. J. Pharm. 647 (2023) 123530]
Corrigendum to “Design, optimization and pharmacokinetic evaluation of PLGA phosphatidylcholine hybrid nanoparticles of triamcinolone acetonide loaded in situ gel for topical ocular delivery” [Int. J. Pharm. 647 (2023) 123530]
Volume 648, 15 December 2023, 123615Author links open overlay panelMohammed Shareef Khan, Punna Rao Ravi, Divya Shrikant D...
Reviewing particulate delivery systems loaded with repurposed tetracyclines – From micro to nanoparticles
Reviewing particulate delivery systems loaded with repurposed tetracyclines – From micro to nanoparticles
Tetracyclines (TCs) are a class of broad-spectrum antibacterial agents recognized for their multifaceted properties, inclu...
Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
AgNPsSilver NanoparticlesAlPcChloroaluminum PhthalocyanineAMPKAMP-activated protein kinaseAPCsAntigen-presenting CellsATF6...
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