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Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury
Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI...
TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish
TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a d...
Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome?
Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome?
This perspective review aims to explore the potential neurobiological mechanisms involved in the application of transcrani...
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic ...
Proteasome localization and activity in pig brain and in vivo small molecule screening for activators
Proteasome localization and activity in pig brain and in vivo small molecule screening for activators
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human li...
Apoptosis and turnover disruption of olfactory sensory neurons in eosinophilic chronic rhinosinusitis
Apoptosis and turnover disruption of olfactory sensory neurons in eosinophilic chronic rhinosinusitis
Olfactory dysfunction (OD) is one of the important and difficult-to-treat symptoms of eosinophilic chronic rhinosinusitis ...
Reactive gliosis in traumatic brain injury: a comprehensive review
Reactive gliosis in traumatic brain injury: a comprehensive review
Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the central nervous system (CNS)....
Editorial: Reviews in cellular neurophysiology 2022: neurophysiological mechanisms in the aging brain
Editorial: Reviews in cellular neurophysiology 2022: neurophysiological mechanisms in the aging brain
advancing age [3]. Neuroinflammation, stemming from various mechanisms, emerges as a pivotal factor in numerous diseases, ...
Visualizing the trans-synaptic arrangement of synaptic proteins by expansion microscopy
Visualizing the trans-synaptic arrangement of synaptic proteins by expansion microscopy
High fidelity synaptic neurotransmission in the millisecond range is provided by a defined structural arrangement of synap...
MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line
MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line
IntroductionDemyelination is one of the hallmarks of multiple sclerosis (MS). While remyelination occurs during the diseas...
Out of the core: the impact of focal ischemia in regions beyond the penumbra
Out of the core: the impact of focal ischemia in regions beyond the penumbra
The changes in the necrotic core and the penumbra following induction of focal ischemia have been the focus of attention f...
Microglia-neuron interactions in schizophrenia
Microglia-neuron interactions in schizophrenia
Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelo...
Editorial: Rising stars in cellular neuropathology 2022
Editorial: Rising stars in cellular neuropathology 2022
Ojeda et al. present a highly detailed analysis of structural and molecular alterations in the spinal cord, neuronal popul...
Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
Injuries to axons within the central nervous system (CNS) pose a substantial clinical challenge due to their limited regen...
Glitches in the brain: the dangerous relationship between radiotherapy and brain fog
Glitches in the brain: the dangerous relationship between radiotherapy and brain fog
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processi...
Editorial: Oligodendrocytes: from their development to function and dysfunction
Editorial: Oligodendrocytes: from their development to function and dysfunction
Human central nervous system (CNS) myelination occurs prior to twenty years old and throughout our lives (Herbert and Monk...
Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amy...
Acute stress modulates hippocampal to entorhinal cortex communication
Acute stress modulates hippocampal to entorhinal cortex communication
Feed-forward inhibition is vital in the transfer and processing of synaptic information within the hippocampal–entorhinal ...
Corrigendum: Spatiotemporal analysis of 3D human iPSC-derived neural networks using a 3D multi-electrode array
Corrigendum: Spatiotemporal analysis of 3D human iPSC-derived neural networks using a 3D multi-electrode array
Corrigendum on: Lam D, Enright HA, Cadena J, George VK, Soscia DA, Tooker AC, Triplett M, Peters SKG, Karande P, Ladd A, B...
Biomarkers associated with the pathogenesis of Alzheimer’s disease
Biomarkers associated with the pathogenesis of Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive degenerative neurological illness with insidious onset. Due to the complexity of...
Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
The diencephalon, an integral component of the forebrain, governs a spectrum of crucial functions, ranging from sensory pr...
Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs
Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs
The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into in...
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine
Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through...
Presynaptic GABAB receptors inhibit vomeronasal nerve transmission to accessory olfactory bulb mitral cells
Presynaptic GABAB receptors inhibit vomeronasal nerve transmission to accessory olfactory bulb mitral cells
Vomeronasal sensory neurons (VSNs) recognize pheromonal and kairomonal semiochemicals in the lumen of the vomeronasal orga...
Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection
Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection
IntroductionCOVID-19 typically causes Q7 respiratory disorders, but a high proportion of patients also reports neurologica...