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Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the USA. SB is often diagnosed before ir...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based...
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ...
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Describe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning ...
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical...
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
To explore the advances and future research directions in image analysis and computational modelling of human stem cells (...
Machine Learning Approaches for Stem Cells
Machine Learning Approaches for Stem Cells
Machine learning (ML) enables high-throughput analysis of multimodal data generated from stem cell experiments such as gen...
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
The underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an ar...
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Hematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells oc...
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
Previous studies involving various mesenchymal stem cell (MSC) sources have reported osteoarthritis (OA) attenuation benef...
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
This paper briefly describes recent mathematical models that use stochastic and deterministic approaches to understand ste...
Stem Cell Banking of Adipose Tissue
Stem Cell Banking of Adipose Tissue
Adult stem cells such as adipose tissue derived cells (ASCs) are often preferred for autologous cellular therapies. Nevert...
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Human pluripotent stem cells have the potential to revolutionize the treatment of inborn and degenerative diseases, includ...
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encounter...
Organoid Technologies for SARS-CoV-2 Research
Organoid Technologies for SARS-CoV-2 Research
Organoids are an emerging technology utilizing three-dimensional (3D), multi-cellular in vitro models to represent the fun...
The Effects of Different Regenerative Treatments after Tooth Avulsion
The Effects of Different Regenerative Treatments after Tooth Avulsion
Traumatic injury to the teeth can cause dental avulsion. There is little time to return the tooth to its socket. Also, aft...
Advances in Biomaterials for Promoting Vascularization
Advances in Biomaterials for Promoting Vascularization
Tissue engineered constructs (TECs)—commonly developed using natural or synthetic biomaterials—are crucially n...
Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine
Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine
Myocardial regeneration is a promising alternative to heart transplantation, but the ideal stem cell type remains unknown ...
Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview
Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview
This review focuses on the opposing effects on the immune system of radiotherapy (RT) and the consequences for combined ca...
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)
Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the d...
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis
Novel radiation therapies with accelerated charged particles such as protons and carbon ions have shown encouraging result...
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics
Cryopreservation and its associated freezing and thawing procedures–short “freeze-thawing”–are amo...
Decoding Human Hematopoietic Stem Cell Self-Renewal
Decoding Human Hematopoietic Stem Cell Self-Renewal
Hematopoietic stem cells (HSCs) maintain blood and immune cell homeostasis by balancing quiescence, self-renewal, and diff...
Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid Cancer
Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid Cancer
Clinical implementation of personalized cancer therapy necessitates translational cancer models that faithfully represent ...
Are Mesenchymal Stem Cells Fibroblasts with Benefits?
Are Mesenchymal Stem Cells Fibroblasts with Benefits?
Mesenchymal stem or stromal cells (MSCs) are a heterogeneous group of non-hematopoietic, multipotent progenitor cells that...
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