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Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells ...
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
A.V.R. Kornepati, R.K. Vadlamudi, T.J. Curiel, Programmed death ligand 1 signals in cancer cells. Nat. Rev. Cancer. 22, 17...
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heter...
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies....
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been ident...
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
The human AlkB homolog (ALKBH) dioxygenase superfamily plays a crucial role in gene regulation and is implicated in cancer...
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase...
BCAT1 contributes to the development of TKI-resistant CML
BCAT1 contributes to the development of TKI-resistant CML
Although most of chronic myeloid leukemia (CML) patients can be effectively treated by the tyrosine kinase inhibitors (TKI...
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Autophagy is frequently observed in tissues during the aging process, yet the tissues most strongly correlated with autoph...
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
Ubiquitination is one of the important modification of proteins which can be reversed by deubiquitinating enzymes (DUBs). ...
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cellular component in the tumor microenvironment (TME)....