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LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
The Hippo pathway in the tumorigenesis and progression of PDAC, with lysophosphatidic acid (LPA) regulating the Hippo path...
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Central nervous system (CNS) involvement and/or relapse remains one of the most important causes of morbidity/mortality in...
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
To propose a new optimal strategy for incorporating tumor deposit (TD) into TNM staging. Totally, 2730 consecutive gastric...
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
Malignant melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. We reported that both Hedgehog-...
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), tumor-associated neutrophils...
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Immune checkpoint plus tyrosine kinase inhibition (IO + TKI) has emerged as the first-line therapy in metastat...
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cance...
Allelic expression imbalance of variants in childhood acute lymphoblastic leukemia
Allelic expression imbalance of variants in childhood acute lymphoblastic leukemia
Germline CDKN2A variant predisposes to childhood acute lymphoblastic leukemia (ALL) through allelic expression imbalance (...
From benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST): a gaming among multiple factors
From benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST): a gaming among multiple factors
Almost all patients of Neurofibromatosis Type I (NF1) develop benign peripheral nerve tumors called neurofibromas, which a...
Tumor-specific CXCR6 positive precursor CD8 T cells mediate tumor control in metastatic melanoma
Tumor-specific CXCR6 positive precursor CD8 T cells mediate tumor control in metastatic melanoma
Adoptive cell therapy (ACT) mediates durable and complete regression of various cancers. However, its efficacy is limited ...
Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance
Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance
Osterix, encoded by SP7, is a transcription factor crucial in osteoblast differentiation and bone formation. While initial...
Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth
Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth
Post-translational modifications, such as lactylation, are emerging as critical regulators of metabolic enzymes in cancer ...
Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis
Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis
Patients who survive the excessive inflammatory phase of sepsis experience prolonged immunoparalysis/immunosuppression. Du...
Exosomes delivering miR-129-5p combined with sorafenib ameliorate hepatocellular carcinoma progression via the KCTD1/HIF-1α/VEGF pathway
Exosomes delivering miR-129-5p combined with sorafenib ameliorate hepatocellular carcinoma progression via the KCTD1/HIF-1α/VEGF pathway
Potassium channel tetramerization domain-containing 1 (KCTD1) plays a critical role in transcriptional regulation and adip...
HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
Epithelial-mesenchymal transition (EMT) plays critical roles in tumor progress and treatment resistance of ovarian cancer ...
THEMIS2 contributes to ovarian cancer metastasis via DOCK4-mediated activation of Rap1 signaling
THEMIS2 contributes to ovarian cancer metastasis via DOCK4-mediated activation of Rap1 signaling
Ovarian cancer (OC) is the most lethal gynecological malignancy, with widespread metastasis and ascites being the leading ...
State of the art in CAR-based therapy: In vivo CAR production as a revolution in cell-based cancer treatment
State of the art in CAR-based therapy: In vivo CAR production as a revolution in cell-based cancer treatment
Chimeric antigen receptor (CAR) therapy has successfully treated relapsed/refractory hematological cancers. This strategy ...
Development and Validation of an Assay to Quantify Plasma Circulating Tumor Human Papillomavirus DNA for 13 High-Risk Types that Cause 98% of HPV-Positive Cancers
Development and Validation of an Assay to Quantify Plasma Circulating Tumor Human Papillomavirus DNA for 13 High-Risk Types that Cause 98% of HPV-Positive Cancers
Plasma circulating tumor HPV DNA (ctHPVDNA) persistence after curative-intent treatment may identify patients with HPV-pos...
Dermatologic Lesions with Eosinophilia in the Head and Neck
Dermatologic Lesions with Eosinophilia in the Head and Neck
Dermatologic lesions with notable eosinophilic infiltration of the head and neck region represent a diverse group of condi...
Eosinophils and the Head and Neck
Eosinophils and the Head and Neck
Tissue eosinophilia is a common finding during histopathologic evaluation and recognizing its presence oftentimes aids pat...
Cemento-Osseous Dysplasia in a Female Bronze Age Skeleton (North Caucasus)
Cemento-Osseous Dysplasia in a Female Bronze Age Skeleton (North Caucasus)
The earliest known case of cemento-osseous dysplasia could be detected in a Bronze Age skeleton, dating back 4500 years ag...
Langerhans Cell Histiocytosis and Other Histiocytic Lesions
Langerhans Cell Histiocytosis and Other Histiocytic Lesions
Histiocytoses, including Langerhans cell histiocytosis (LCH), comprise a diverse group of histiocytic disorders characteri...
Laryngeal Coccidioidomycosis Mimicking Squamous Cell Carcinoma
Laryngeal Coccidioidomycosis Mimicking Squamous Cell Carcinoma
Coccidioidomycosis is a rare fungal infection that can closely mimic squamous cell carcinoma (SCC) clinically and radiolog...
Intraneural Pseudoperineuriomatous Proliferations and Traumatic Neuromas: A Retrospective Multicenter Study of Clinicopathological Characteristics
Intraneural Pseudoperineuriomatous Proliferations and Traumatic Neuromas: A Retrospective Multicenter Study of Clinicopathological Characteristics
Described in 2013, intraneural pseudoperineuriomatous proliferations (IPP) present perineurial cells concentrically surrou...
12q Amplification Characterizes a Distinctive Salivary Gland Tumor with Bizarre Myoepithelial Atypia
12q Amplification Characterizes a Distinctive Salivary Gland Tumor with Bizarre Myoepithelial Atypia
Over the past two decades, an increased understanding of molecular alterations has greatly refined salivary gland tumor cl...
Histopathology of Chronic Rhinosinusitis and Sinonasal Inflammatory Polyps
Histopathology of Chronic Rhinosinusitis and Sinonasal Inflammatory Polyps
Sinus content specimens from patients with chronic rhinosinusitis (CRS) are commonly encountered by surgical pathologists ...
Calcifying Epithelial Odontogenic Tumour (Pindborg Tumour): A Report of 20 Cases and Review of the Literature
Calcifying Epithelial Odontogenic Tumour (Pindborg Tumour): A Report of 20 Cases and Review of the Literature
The aim of the present work was to analyze 20 cases of calcifying epithelial odontogenic tumour (CEOT), also known as R...
BRAF p.V600E-Negative Langerhans Cell Histiocytosis Associated with a Periapical Cyst: A Case Presentation with Broad Review of the Differential Diagnosis and Disease Pathophysiology
BRAF p.V600E-Negative Langerhans Cell Histiocytosis Associated with a Periapical Cyst: A Case Presentation with Broad Review of the Differential Diagnosis and Disease Pathophysiology
Langerhans cell histiocytosis (LCH) rarely presents in the oral and maxillofacial region, and while isolated and small col...
Oncocytic Mucoepidermoid Carcinoma of the Parotid Gland
Oncocytic Mucoepidermoid Carcinoma of the Parotid Gland
A 30-year-old man presented with a multilobulated left parotid mass measuring 5.2 × 4.1 ×̴...
Infectious Diseases in the Head and Neck with Eosinophilia
Infectious Diseases in the Head and Neck with Eosinophilia
Eosinophilia, defined as an elevated eosinophil count either in blood or tissue, has diverse implications for diagnosing a...
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