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Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks
Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks
Procaspase-8 is a key mediator of death receptor (DR)-mediated pathways. Recently, the role of post-translational modifica...
Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer
Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer
Ovarian cancer is one of the most common gynecological malignant tumors with insidious onset, strong invasiveness, and poo...
Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation
Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation
Lung adenocarcinoma (LUAD) is one of the most prevalent types of cancer. Ubiquitination is crucial in modulating cell prol...
Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the USP2-NCOA4 axis
Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the USP2-NCOA4 axis
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive system. Hypoxia is a crucial player i...
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer
Somatic copy number alterations (SCNAs) are prevalent in cancer and play a significant role in both tumorigenesis and ther...
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, ac...
TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation
TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation
Non-alcoholic steatohepatitis (NASH) is rapidly surpassing viral hepatitis as the primary cause of hepatocellular carcinom...
RAF1 facilitates KIT signaling and serves as a potential treatment target for gastrointestinal stromal tumor
RAF1 facilitates KIT signaling and serves as a potential treatment target for gastrointestinal stromal tumor
The aberrant activation of RAS/RAF/MEK/ERK signaling is important for KIT mutation-mediated tumorigenesis of gastrointesti...
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USAShoumin Zhu, Mohammed Soutto, Zheng Ch...
ROS production by mitochondria: function or dysfunction?
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions....
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies hav...
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of c...
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor prognosis due to a lack of early detecti...
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression prog...
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
Reprogramming of lipid metabolism during hepatocarcinogenesis is not well elucidated. Here, we aimed to explore pivotal RN...
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits...
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Klotho, a 1012 amino acid transmembrane protein, is a potent tumor suppressor in different cancer types. Klotho is compose...
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling. Although there has been substantia...
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Dendritic cells (DCs) play critical roles in recognizing and presenting antigens to T cells. They secrete dendritic cell-d...
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effec...
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitute...
PRAME induces genomic instability in uveal melanoma
PRAME induces genomic instability in uveal melanoma
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in ...
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative...
Correction: DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation
Correction: DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation
A Pol β was knocked down in MCF-7 and A549 cells. Western blot analysis of protein levels of Pol β. B, D Representative im...
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
Ewing sarcomas (ES) are aggressive paediatric tumours of bone and soft tissues. Resistance to chemotherapy and high propen...
Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer
Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer
A proportion of gastric cancer (GC) patients suffer from peritoneal metastasis (PM) in the late stage of tumor and these p...
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression
Ovarian cancer has poor survival outcomes particularly for advanced stage, metastatic disease. Metastasis is promoted by i...
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelium is a stratified epithelium composed of basal cells, one or more layers of intermediate cells, and an upper ...
Selective inhibition of CDK9 in triple negative breast cancer
Selective inhibition of CDK9 in triple negative breast cancer
Targeted therapy for triple-negative breast cancers (TNBC) remains a clinical challenge due to tumour heterogeneity. Since...
Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination
Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination
Homologous recombination (HR) is a major DNA double-strand break (DSB) repair pathway of clinical interest because of trea...
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