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Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Triplostegia glandulifera Wall (T. glandulifera) is an ethnomedicine commonly used by ethnic minorities in Yunnan, China, ...
Natural and revolutionary tumor-specific T-cell therapy
Natural and revolutionary tumor-specific T-cell therapy
Recently the FDA conducted a risk investigation and labeled the Boxed Warning for all BCMA- and CD19-directed CAR-T cell t...
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the...
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Arctium lappa, widely recognized as burdock, is a perennial plant that is employed in the realm of traditional Chinese med...
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These...
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Functionalized mesoporous materials have become a promising carrier for enzyme immobilization. In this study, Santa Barbar...
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (1–4 and 12–18), along with nine known compo...
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining in...
Recent advances in pharmaceutical cocrystals of theophylline
Recent advances in pharmaceutical cocrystals of theophylline
Currently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical...
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Iminosugars, a class of polyhydroxylated cyclic alkaloids with intriguing properties, hold promising therapeutic potential...
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Insulin-like growth factor-1 (IGF-1) is considered as a pathogenic factor contributing to sebaceous gland dysfunction, whi...
Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.
Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.
Four new isoquinoline alkaloids, hypecotumines A-D (1–4), were isolated and identified from the whole herbs of Hypec...
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway
Viral pneumonia is characterized by inflammation in the lungs triggered by respiratory viruses. Dayuan Yin (DYY), a tradit...
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A − I (1–7, 9 and 10...
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway
This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizom...
Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities
Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities
Thirty-six structurally diverse sesquiterpenoids, including caryolanes (1–12), germacranes (13–16), isodaucane...
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-...
Natural-derived acetophenones: chemistry and pharmacological activities
Natural-derived acetophenones: chemistry and pharmacological activities
Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains...
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successful...
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subt...
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most v...
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
N-Hydroxyapiosporamide (N-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory...
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
Four extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditio...
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferropt...
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thio...
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of C...
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and i...
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS re...
5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
Alzheimer’s disease (AD) is a complex neurodegenerative condition. 5α-epoxyalantolactone (5α-EAL), a eudes...
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Plants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant&#...
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