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Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Two novel koninginin derivatives, koningipyridines A and B (1 and 2), along with four known compounds (3˗6) were isol...
Precision enzyme discovery through targeted mining of metagenomic data
Precision enzyme discovery through targeted mining of metagenomic data
Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms, which may s...
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Saffron has many pharmacological properties in addition to being a frequently used food seasoning. Crocin and picrocrocin ...
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction...
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natur...
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake...
Natural and engineered xylosyl products from microbial source
Natural and engineered xylosyl products from microbial source
Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural di...
Chemistry and biology of marine-derived Trichoderma metabolites
Chemistry and biology of marine-derived Trichoderma metabolites
Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with va...
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
A type of high molecular weight bioactive polymers called exopolysaccharides (EPS) are produced by thermophiles, the extre...
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 mi...
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, ...
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various ...
Current advances on the therapeutic potential of scutellarin: an updated review
Current advances on the therapeutic potential of scutellarin: an updated review
Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteracea...
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological p...
Which is the optimal choice for neonates’ formula or breast milk?
Which is the optimal choice for neonates’ formula or breast milk?
The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerab...
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies her...
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two othe...
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalenc...
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz...
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Norepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β2AR) ...
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
Four highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A–C possess a...
A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra
A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra
Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chl...
Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities
Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities
Plants of the genus Cordia (Boraginaceae family) are widely distributed in the tropical regions of America, Africa, and As...
Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarc...
The alkynyl-containing compounds from mushrooms and their biological activities
The alkynyl-containing compounds from mushrooms and their biological activities
Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are ...
A recent update on development, synthesis methods, properties and application of natural products derived carbon dots
A recent update on development, synthesis methods, properties and application of natural products derived carbon dots
Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with ...
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies
Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing inter...
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated ...
Occurrence of D-amino acids in natural products
Occurrence of D-amino acids in natural products
Since the identified standard genetic code contains 61 triplet codons of three bases for the 20 L-proteinogenic amino acid...
l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
l-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are invol...
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