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Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
This study aimed to investigate the potential of corylin, a bioactive compound isolated from the aerial part of Pueraria l...
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Antimicrobial resistance is one of the most pressing global health challenges, as many pathogens are rapidly evolving to e...
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
Sesquiterpenoids represent a structurally diverse class of natural products widely recognized for their ecological signifi...
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Pseudomonas aeruginosa-induced bacterial keratitis is one of the most sight-threatening corneal infections associated with...
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
In this work, six pairs of undescribed enantiomeric prenylated flavonoids, ( ±)-epimesatines J–O (1a/1b&#...
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids (1–3) cont...
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Otteacumienes G–K (1–5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptano...
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Our continuous study of the fruits of Garcinia xanthochymus and Garcinia subelliptica led to the isolation and structural ...
Chemical constituents of leaves and their anti-rheumatoid arthritis activity in vitro
Chemical constituents of leaves and their anti-rheumatoid arthritis activity in vitro
Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidate...
Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics inand
Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics inand
The use of natural products as antibiotic adjuvants to enhance efficacy and mitigate resistance is increasingly recognized...
Bridging chemical space and biological efficacy: advances and challenges in applying generative models in structural modification of natural products
Bridging chemical space and biological efficacy: advances and challenges in applying generative models in structural modification of natural products
Natural products (NPs) are invaluable resources for drug discovery, characterized by their intricate scaffolds and diverse...
Design of 20-deoxyingenol-esters-based PKC agonists and their lysosome biogenesis-enhancing activity
Design of 20-deoxyingenol-esters-based PKC agonists and their lysosome biogenesis-enhancing activity
The activation of conventional (α) and novel (δ) protein kinase C (PKC) isoforms promotes lysosomal biogenesis, ...
Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D
Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D
Qingfei Paidu decoction (QFPDD) has been extensively used in clinical treatments during the severe acute respiratory syndr...
Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity from Maxim.
Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity from Maxim.
Four previously undescribed polyprenylated acylphloroglucinols, hyperisenins A–D (1–4), along with two known a...
Review on NMR spectroscopic data and recent analytical methods of aristolochic acids and derivatives in herbs
Review on NMR spectroscopic data and recent analytical methods of aristolochic acids and derivatives in herbs
Aristolochic acids (AAs) are an important group of secondary metabolites in the genus Aristolochia. The presence of aristo...
Bioprospecting cultivable bacteria associated with deep sea (mesopelagic) fish of the North Atlantic Ocean
Bioprospecting cultivable bacteria associated with deep sea (mesopelagic) fish of the North Atlantic Ocean
The microbiota associated with fish is increasingly recognized as a valuable source of bioactive metabolites for pharmaceu...
Exploring the antineoplastic potential of α-mangostin in breast cancer
Exploring the antineoplastic potential of α-mangostin in breast cancer
Among women, breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality globa...
Unlocking potent anti-tuberculosis natural products through structure–activity relationship analysis
Unlocking potent anti-tuberculosis natural products through structure–activity relationship analysis
Tuberculosis (TB) remains a world health problem due to the high number of affected individuals, high mortality rates, pro...
Chemoprofiling of (Loisel.) P. Delforge leaves reveals predominance of gastrodigenin and structurally related compounds
Chemoprofiling of (Loisel.) P. Delforge leaves reveals predominance of gastrodigenin and structurally related compounds
The purpose of this study was to phytochemically profile Himantoglossum robertianum leaves. In fact, despite its wide dist...
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Triplostegia glandulifera Wall (T. glandulifera) is an ethnomedicine commonly used by ethnic minorities in Yunnan, China, ...
Natural and revolutionary tumor-specific T-cell therapy
Natural and revolutionary tumor-specific T-cell therapy
Recently the FDA conducted a risk investigation and labeled the Boxed Warning for all BCMA- and CD19-directed CAR-T cell t...
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the...
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Arctium lappa, widely recognized as burdock, is a perennial plant that is employed in the realm of traditional Chinese med...
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These...
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Functionalized mesoporous materials have become a promising carrier for enzyme immobilization. In this study, Santa Barbar...
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (1–4 and 12–18), along with nine known compo...
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining in...
Recent advances in pharmaceutical cocrystals of theophylline
Recent advances in pharmaceutical cocrystals of theophylline
Currently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical...
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Iminosugars, a class of polyhydroxylated cyclic alkaloids with intriguing properties, hold promising therapeutic potential...
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Insulin-like growth factor-1 (IGF-1) is considered as a pathogenic factor contributing to sebaceous gland dysfunction, whi...
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