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Decomposition of 2,4-dihalophenols by dehaloperoxidase activity and spontaneous reaction with hydrogen peroxide
Decomposition of 2,4-dihalophenols by dehaloperoxidase activity and spontaneous reaction with hydrogen peroxide
Catalytic oxidation of chlorinated and brominated phenols by peroxidases is well known. [[1], [2], [3], [4], [5]] Dehalope...
Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity
Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity
Chalcone and its derivatives, known as chalconoids, represent a well-known and biologically important group of natural com...
Zinc complexes of chloroquine and hydroxychloroquine versus the mixtures of their components: Structures, solution equilibria/speciation and cellular zinc uptake
Zinc complexes of chloroquine and hydroxychloroquine versus the mixtures of their components: Structures, solution equilibria/speciation and cellular zinc uptake
The zinc complexes of chloroquine (CQ; [Zn(CQH+)Cl3]) and hydroxychloroquine (HO-CQ; [Zn(HO-CQH+)Cl3]) were synthesized an...
N-heterocyclic-carbene vs diphosphine auxiliary ligands in thioamidato Cu(I) and Ag(I) complexes towards the development of potent and dual-activity antibacterial and apoptosis-inducing anticancer agents
N-heterocyclic-carbene vs diphosphine auxiliary ligands in thioamidato Cu(I) and Ag(I) complexes towards the development of potent and dual-activity antibacterial and apoptosis-inducing anticancer agents
A growing interest in the development of novel metallodrugs arose over the last decades, as a consequence of the emerging ...
Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm
Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm
The Shewanella species are a diverse group of facultative anaerobic bacteria that are widely distributed in aquatic enviro...
Soluble meso and deuteroporphyrin analogs of the malaria pigment hematin anhydride
Soluble meso and deuteroporphyrin analogs of the malaria pigment hematin anhydride
The heme detoxification pathway in the digestive vacuole in the intra-red blood cell stage of malaria is a unique biochemi...
Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials
Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials
A variety of mercury compounds have played [1] and continue to play an important role in biology and medicine [2]. In rece...
Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation
Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation
The enduring structure-activity relationship for platinum antitumor agents is that the trans geometry is inactive. Yet sub...
In Memoriam – Ademir Neves *1951-†2022
In Memoriam – Ademir Neves *1951-†2022
Volume 252, March 2024, 112485Author links open overlay panelRosely A. Peralta 1Show morePrevious article in issueNext art...
JIB Ademir Neves Special Issue Preface/Editorial
JIB Ademir Neves Special Issue Preface/Editorial
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans?
Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans?
Capsella bursa-pastoris, commonly known as shepherd's purse, is a highly prevalent flowering plant found across the globe ...
Hole-scavenging in photo-driven N2 reduction catalyzed by a CdS-nitrogenase MoFe protein biohybrid system
Hole-scavenging in photo-driven N2 reduction catalyzed by a CdS-nitrogenase MoFe protein biohybrid system
The light-driven reduction of dinitrogen (N2) to ammonia (NH3) catalyzed by a cadmium sulfide (CdS) nanocrystal‑nitrogenas...
Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy
Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy
KeywordsHeteroscorpionate ligandsTNBCRAPTA derivativesPreclinical evaluationUptake studiesFluorescence lifetime imaging mi...
Redox potentials elucidate the electron transfer pathway of NAD+-dependent formate dehydrogenases
Redox potentials elucidate the electron transfer pathway of NAD+-dependent formate dehydrogenases
bis-MGDbis-metal-binding pterin guanine dinucleotideCAPSN-cyclohexyl-3-aminopropanesulfonic acidcryo-EMcryogenic electron ...
Monomeric copper(II) complexes with unsymmetrical salen environment: Synthesis, characterization and study of biological activities
Monomeric copper(II) complexes with unsymmetrical salen environment: Synthesis, characterization and study of biological activities
Nowadays cancer is one of the leading causes of mortality worldwide and chemotherapy has been shown to be the most success...
Determination of the role of specific amino acids in the binding of Zn(II), Ni(II), and Cu(II) to the active site of the M10 family metallopeptidase
Determination of the role of specific amino acids in the binding of Zn(II), Ni(II), and Cu(II) to the active site of the M10 family metallopeptidase
Metallopeptidases (MPs) represent a class of enzymes categorized as proteases. Their function is to catalyze hydrolysis re...
Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms
Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms
Amyloid beta (Aβ) peptides became the subject of intense interest in the 1980s when the amyloid cascade hypothesis (ACH) w...
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
In the context of chemotherapeutic drugs, platinum-based complexes have dominated the scene for decades, remaining among t...
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
Regarding inorganic chemistry, coordination chemistry is at the forefront of innovation and exploration. Since this subfie...
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
Recognized as the ‘guardian of the genome’, the p53 protein has been an important drug target since its discovery in 1979 ...
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
Cancer continues to pose a global threat, underscoring the urgent need for more effective and safer treatment options. Gol...
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths in the world [1]. The HCC incidence is ...
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium-μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium-μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
In the context of their close resemblance to natural enzymatic systems, tetrapyrrole metal complexes, such as heme, chloro...
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
Over the last decades, many efforts have been devoted towards the development of novel therapeutic approaches to treat can...
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
Oral cancer is a particularly serious oral disease. It occurs in the tongue, lips, cheeks, and floor of the mouth. Oral sq...
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
When inhaled, chromate is a well-known mutagen and human carcinogen [1]. Unlike cationic Cr(III) complexes, anionic chroma...
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
Traditional anti-cancer chemotherapy often has toxic and side effects [[1], [2], [3]]. Therefore, the development of novel...
Structure prediction of physiological bis(amino acidato)copper(II) species in aqueous solution: The copper(II) compounds with l-glutamine and l-histidine
Structure prediction of physiological bis(amino acidato)copper(II) species in aqueous solution: The copper(II) compounds with l-glutamine and l-histidine
Copper is both essential and toxic metal for living systems. As an essential trace element, copper participates in physiol...
Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a
Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a
Metals are involved in many physiological processes, with many proteins requiring a metal cofactor to perform their functi...
Chemistry meets biology in the coordination dynamics of metalloproteins
Chemistry meets biology in the coordination dynamics of metalloproteins
At least 30% of proteins contain a metal ion for catalysis, structure, or regulation. In addition to these roles of metal ...
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