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State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?
State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?
Metastatic spread of tumour cells to tissues and organs around the body is the most frequent cause of death from breast ca...
Perimenopausal and Menopausal Mammary Glands In A 4-Vinylcyclohexene Diepoxide Mouse Model
Perimenopausal and Menopausal Mammary Glands In A 4-Vinylcyclohexene Diepoxide Mouse Model
As both perimenopausal and menopausal periods are recognized critical windows of susceptibility for breast carcinogenesis,...
Immune Cell Contribution to Mammary Gland Development
Immune Cell Contribution to Mammary Gland Development
Postpartum breast cancer (PPBC) is a unique subset of breast cancer, accounting for nearly half of the women diagnosed dur...
Using Organoids to Tap Mammary Gland Diversity for Novel Insight
Using Organoids to Tap Mammary Gland Diversity for Novel Insight
This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology...
Exploring the One Health Paradigm in Male Breast Cancer
Exploring the One Health Paradigm in Male Breast Cancer
How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowle...
A novel preclinical model of the normal human breast
A novel preclinical model of the normal human breast
Improved screening and treatment have decreased breast cancer mortality, although incidence continues to rise. Women at in...
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the e...
Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells
Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells
The transcription factor STAT3 is activated by multiple cytokines and other extrinsic factors. It plays a key role in immu...
Rat Models of Hormone Receptor-Positive Breast Cancer
Rat Models of Hormone Receptor-Positive Breast Cancer
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, account...
Transcriptomic Analysis of Pubertal and Adult Virgin Mouse Mammary Epithelial and Stromal Cell Populations
Transcriptomic Analysis of Pubertal and Adult Virgin Mouse Mammary Epithelial and Stromal Cell Populations
Conflicting data exist as to how mammary epithelial cell proliferation changes during the reproductive cycle. To study the...
Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made u...
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the d...
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating t...
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Tumor mass comprises not only cancer cells but also heterogeneous populations of immune and stromal cells, along with the ...
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral ...
Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer
Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer
Metastasis is the leading cause of cancer-related deaths of breast cancer patients. Some cancer cells in a tumour go throu...
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
The lymphatic system is a major gateway for tumor cell dissemination but the mechanisms of how tumor cells gain access to ...
A molecular toolbox to study progesterone receptor signaling
A molecular toolbox to study progesterone receptor signaling
Progesterone receptor (PR) signaling is required for mammary gland development and homeostasis. A major bottleneck in stud...
High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells
High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells
Inflammatory breast cancer (IBC) presents as rapid-onset swelling and breast skin changes caused by tumor emboli in the br...
Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
The fourteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gla...
RETRACTED ARTICLE: Pure Primary Squamous Cell Carcinoma of the Breast Arising from the Epithelium of a Complex Mammary Cyst: A Case Report
RETRACTED ARTICLE: Pure Primary Squamous Cell Carcinoma of the Breast Arising from the Epithelium of a Complex Mammary Cyst: A Case Report
The Editor-in-Chief has retracted this article because it was published in error before peer review, and because of concer...
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate diverse biological processes includ...
Non-Linear Lymphatic Anatomy in Breast Cancer Patients Prior to Axillary Lymph Node Dissection: A Risk Factor For Lymphedema Development
Non-Linear Lymphatic Anatomy in Breast Cancer Patients Prior to Axillary Lymph Node Dissection: A Risk Factor For Lymphedema Development
Immediate lymphatic reconstruction (ILR) at the time of axillary lymph node dissection (ALND) has become increasingly util...
Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals
Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals
In 2010 the worldwide population of domesticated ruminants was estimated to be 3.6 bi...
Gestational Breast Cancer – a Review of Outcomes, Pathophysiology, and Model Systems
Gestational Breast Cancer – a Review of Outcomes, Pathophysiology, and Model Systems
The onset of pregnancy marks the start of offspring development, and represents the key physiological event that induces r...
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
On 8 December 2022 the organizing committee of the European Network for Breast Development and Cancer labs (ENBDC) held it...
SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours
SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours
Canine mammary tumours (CMTs) are the most frequent tumours in intact female dogs and show strong similarities with human ...
Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas
Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas
Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours includi...
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer
The protein tyrosine phosphatase SHP2 activates oncogenic pathways downstream of most receptor tyrosine kinases (RTK) and ...
Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective
Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective
Breast cancer is well-known to be a highly heterogenous disease. This facet of cancer makes finding a research model that ...
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