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Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Neurons are dependent on efficient quality control mechanisms to maintain cellular homeostasis and function due to their p...
MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat
MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat
The leading cause of steroid-induced femoral head osteonecrosis (ONFH) is the imbalance of bone homeostasis. Bone marrow-d...
AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine
AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine
Intraepithelial lymphocytes (IELs) reside in the epithelial layer and protect against foreign pathogens, maintaining the e...
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Mounting evidence has implicated the RNA m6A methylation catalyzed by METTL3 in a wide range of physiological and patholog...
Mechanisms for assembly of the nucleoplasmic reticulum
Mechanisms for assembly of the nucleoplasmic reticulum
The nuclear envelope consists of an outer membrane connected to the endoplasmic reticulum, an inner membrane facing the nu...
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Fibronectin (FN) is an extracellular matrix glycoprotein essential for the development and function of major vertebrate or...
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
Our previous study found that tumor suppressor nitrogen permease regulator like-2(NPRL2) is frequently downregulated in gl...
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
Certain immune cells, including neutrophils, macrophages, dendritic cells, B cells, Breg cells, CD4+ T cells, CD8+ T cells...
KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability
KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability
The existence of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) is considered to be the key factor fo...
SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus
SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus
Zinc (Zn) transporters contribute to the maintenance of intracellular Zn homeostasis in vertebrate, whose activity and fun...
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
CFTR is an anion channel that has evolved from the mold of an ABC transporter. It possesses specific structural features, ...
Functional diversification process of opsin genes for teleost visual and pineal photoreceptions
Functional diversification process of opsin genes for teleost visual and pineal photoreceptions
Most vertebrates have a rhodopsin gene with a five-exon structure for visual photoreception. By contrast, teleost fishes h...
Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines
Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines
The establishment of epiblast-derived pluripotent stem cells (PSCs) from cattle, which are important domestic animals that...
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
The mammalian imprinted Dlk1-Dio3 domain contains multiple lncRNAs, mRNAs, the largest miRNA cluster in the genome and fou...
Myosin-5a facilitates stress granule formation by interacting with G3BP1
Myosin-5a facilitates stress granule formation by interacting with G3BP1
Stress granules (SGs) are non-membranous organelles composed of mRNA and proteins that assemble in the cytosol when the ce...
MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation
MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an enveloped, positive-sense RNA virus that emerged in 2012, ca...
Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response
Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response
DNA damage induced by oxidative stress during cardiac hypertrophy activates the ataxia telangiectasia mutated (ATM)-mediat...
Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55
Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55
Gap junctions formed by the major neuronal connexin Cx36 function as electrical synapses in the nervous system and provide...
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1
Increasing cyclic GMP activates 26S proteasomes via phosphorylation by Protein Kinase G and stimulates the intracellular d...
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulm...
Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e
Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e
Adenine base editors (ABEs), consisting of CRISPR Cas nickase and deaminase, can chemically convert the A:T base pair to G...
Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
Pulmonary hypertension (PAH) is a cardiopulmonary disease in which pulmonary artery pressure continues to rise, leading to...
The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth
The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth
Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect che...
Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm
Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm
Blood ultrafiltration in nephrons critically depends on specialized intercellular junctions between podocytes, named slit ...
Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Through Smad3-dependent signalings, transforming growth factor-β (TGF-β) suppresses the development, maturation,...
Structure, regulation, and mechanisms of nonmuscle myosin-2
Structure, regulation, and mechanisms of nonmuscle myosin-2
Members of the myosin superfamily of molecular motors are large mechanochemical ATPases that are implicated in an ever-exp...
Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification
Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification
Heterotopic ossification (HO) occurs as a common complication after injury, while its risk factor and mechanism remain unc...
Virus neutralization assays for human respiratory syncytial virus using airway organoids
Virus neutralization assays for human respiratory syncytial virus using airway organoids
Neutralizing antibodies are considered a correlate of protection against severe human respiratory syncytial virus (HRSV) d...
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens
It has been recently established that GPR158, a class C orphan G protein-coupled receptor, serves as a metabotropic glycin...
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal development. Dynamic changes ...
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