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Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia–reperfusion injury in steatotic liver transplantation
Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia–reperfusion injury in steatotic liver transplantation
Due to a lack of donor grafts, steatotic livers are used more often for liver transplantation (LT). However, steatotic don...
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
Interaction between programmed death-1 (PD-1) ligand 1 (PD-L1) on tumor cells and PD-1 on T cells allows tumor cells to ev...
Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction
Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction
C3G is a Rap1 GEF that plays a pivotal role in platelet-mediated processes such as angiogenesis, tumor growth, and metasta...
Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In paralle...
FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation
FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation
The existence of cancer stem cells is widely acknowledged as the underlying cause for the challenging curability and high ...
KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes
KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes
Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological proc...
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested ...
Role of Sam68 as an adaptor protein in inflammatory signaling
Role of Sam68 as an adaptor protein in inflammatory signaling
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulatin...
Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum
Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum
Extracellular vesicles (EVs) are important players in melanoma progression, but their use as clinical biomarkers has been ...
CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape
CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape
It is known that about 10 circular RNAs (circRNAs) can encode functional polypeptides in higher mammals. However, it is no...
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
The maintenance of genome integrity in the germline is crucial for mammalian development. Long interspersed element type 1...
WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway
WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway
Stem Leydig cells (SLCs) are essential for maintaining normal spermatogenesis as the significant component of testis micro...
Emerging role of complement in COVID-19 and other respiratory virus diseases
Emerging role of complement in COVID-19 and other respiratory virus diseases
The complement system, a key component of innate immunity, provides the first line of defense against bacterial infection;...
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway
Activation of hepatic stellate cells (HSCs) has been demonstrated to play a pivotal role in the process of liver fibrogene...
Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memor...
Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium
Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium
Human induced pluripotent stem cells (hiPSCs) offer opportunities to study human biology where primary cell types are limi...
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Proneural genes play a crucial role in neuronal differentiation. However, our understanding of the regulatory mechanisms g...
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Cell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organiz...
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
In hormone-responsive breast cancer cells, progesterone (P4) has been shown to act via its nuclear receptor (nPR), a ligan...
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue a...
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms of MFSD7b...
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
Ovarian cancer is amongst the most morbid of gynecological malignancies due to its diagnosis at an advanced stage, a trans...
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Apolipoproteins co-deposit with amyloids, yet apolipoprotein–amyloid interactions are enigmatic. To understand how a...
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male infertility, while the pathogeneti...
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Parkinson’s disease (PD) is one of the most common neuro-degenerative diseases characterized by α-synuclein acc...
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
The lymphatic vasculature plays a crucial role in fluid clearance and immune responses in peripheral organs by connecting ...
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and lon...
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide replication advantage to the virus and ...
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum...
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
Recent findings suggest an important role for the dysregulation of stromal interaction molecule (STIM) proteins, activator...
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