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Plant-based diet and oxidative stress-induced DNA damage in post-surgery colorectal cancer patients: Results from a randomized controlled trial
Volume 233, June 2025, Pages 240-249Author links open overlay panel, , , , , , , , , , , , Highlights•A plant-based diet r...
Formin INF2 supplementation alleviates cytoskeleton-based mitochondria defects for oocyte quality under obesity
Obesity is one common cause of reproductive health problem, which causes infertility issue worldwide though affecting the ...
Nitric oxide mediates negative feedback on the TXNIP/NLRP3 inflammasome pathway to prevent retinal neurovascular unit dysfunction in early diabetic retinopathy
Diabetic Retinopathy (DR) is the most severe ocular complication of diabetes mellitus (DM) and the leading cause of blindn...
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing
Diabetic peripheral neuropathy (DPN) is a major clinical challenge and one of the most common and debilitating complicatio...
Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite
Volume 233, June 2025, Pages 317-329Author links open overlay panel, , , Highlights•VC/VK3 triggers oxidative stress and i...
Developing a physiologically relevant cell model of ferroptosis in cardiomyocytes
Volume 233, June 2025, Pages 330-339Author links open overlay panel, , , , Highlights•Iron and ROS alone trigger ferroptos...
Betulinic acid protects against lipopolysaccharide and ferrous sulfate-induced oxidative stress, ferroptosis, apoptosis, and neuroinflammation signaling relevant to Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative condition marked by the gradual degeneration of dopaminergic neuron...
Paeoniflorin alleviated experimental Sjögren's syndrome by inhibiting NLRP3 inflammasome activation of submandibular gland cells via activating Nrf2/HO-1 pathway
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease [1]. The main clinical manifestations of SS are dry m...
Non-genetic and genetic determinants of serum selenium and selenium species in the Aragon Workers Health Study
Selenium is an essential trace element for most organisms, including humans, and plays a key role in multiple biological p...
Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response
Throughout the human lifespan, several factors such as diet, physical activity, aging, illness, infections, pollutants, an...
Evidence that the aryl hydrocarbon receptor orchestrates oxinflammatory responses and contributes to airborne particulate matter-induced skin aging
Due to improved living conditions and high medical standards, the proportion of elderly is continuously increasing in the ...
Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging
Skin function depends on a meticulously regulated dynamic interaction of distinct skin compartments such as the epidermis ...
Endoplasmic reticulum stress-autophagy axis is involved in copper-induced ovarian ferroptosis
Copper (Cu) is an essential trace metal element that plays a key role in the growth and development of the body. However, ...
Inactivation of mitochondrial pyruvate dehydrogenase by singlet oxygen involves lipoic acid oxidation, side-chain modification and structural changes
Volume 234, July 2025, Pages 19-33Author links open overlay panel, , , Highlights•The mitochondrial pyruvate dehydrogenase...
Transcription factor KLF5 regulates MsrB1 to promote colorectal cancer progression by inhibiting ferroptosis through β-catenin
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide [1] and is the second most common cause of cancer d...
A hemicyanine-based dual-modal probe for fluorescence and mass spectrometry imaging of peroxynitrite in biosamples
Peroxynitrite (ONOO−) is a highly reactive and destructive oxygen species that is formed by the diffusion-controlled react...
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory joint disease [1]. The global prevalence of RA is...
Intermedin protects peritubular capillaries by inhibiting eNOS uncoupling through AMPK/GTPCH-I/BH4 pathway and alleviate CKD following AKI
Volume 234, July 2025, Pages 72-85Author links open overlay panel, , , , , , , , , , , , , , Highlights•IMD protects again...
Nicotinamide mononucleotide mitigates hyperoxia-aggravated septic lung injury via the GPx4-mediated anti-ferroptosis signaling pathway in alveolar epithelial cells
Sepsis is a major disease associated with uncontrolled host response to infections [1]. The lung is highly susceptible to ...
The glutathione system maintains the thiol redox balance in the mitochondria of fission yeast
The thioredoxin and glutathione (GSH)-glutaredoxin electron donor pathways provide a reducing environment to the cell and ...
Multi-immunometabolomics mining: NP prevents hyperimmune in ALI by inhibiting Leucine/PI3K/Akt/mTOR signaling pathway
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Nitrosyl hemoglobin formation from nitrite in normal and sickle blood
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Inhibition of acid-sensing receptor GPR4 attenuates neuronal ferroptosis via RhoA/YAP signaling in a rat model of subarachnoid hemorrhage
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APEX1 in intestinal epithelium triggers neutrophil infiltration and intestinal barrier damage in ulcerative colitis
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Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling
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Quantitative spatial visualization of X-ray irradiation via redox reaction by dynamic nuclear polarization magnetic resonance imaging
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Melatonin ameliorates chronic sleep deprivation against memory encoding vulnerability: Involvement of synapse regulation via the mitochondrial-dependent redox homeostasis-induced autophagy inhibition
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2-Acetylacteoside improves recovery after ischemic stroke by promoting neurogenesis via the PI3K/Akt pathway
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Nox4 is involved in acute kidney injury associated to intravascular hemolysis
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CREBRF regulates apoptosis and estradiol via ISG15/ISGylation in pig granulosa cells
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