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Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion
Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion
Sestrins are metabolic regulators that respond to stress by reducing the levels of reactive oxygen species (ROS) and inhib...
An upstream open reading frame (5′-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2α
An upstream open reading frame (5′-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2α
Volume 214, March 2024, Pages 129-136Author links open overlay panel, Highlights•A conserved upstream open reading frame (...
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer
The exploration of drugs derived from natural sources holds significant promise in addressing current limitations in ovari...
Novel perfluorocarbon-based oxygenation therapy alleviates Post-SAH hypoxic brain injury by inhibiting HIF-1α
Novel perfluorocarbon-based oxygenation therapy alleviates Post-SAH hypoxic brain injury by inhibiting HIF-1α
Subarachnoid hemorrhage (SAH), resulting from the rupture of intracranial aneurysms for approximately 85% of all cases, co...
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
BackgroundThe effects of a solitary neonatal exposure to anesthesia plus surgery (anesthesia/surgery) on cognitive functio...
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction
Diabetes mellitus (DM) is a metabolic and endocrinological disorder characterized by high blood glucose levels [1]. It is ...
The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis
The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis
Ulcerative colitis (UC) is a prominent form of inflammatory bowel disease (IBD), yet its underlying mechanisms remain elus...
Corrigendum to “NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy” [Free Radic. Biol. Med. 65 (2013) 897–907]
Corrigendum to “NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy” [Free Radic. Biol. Med. 65 (2013) 897–907]
Volume 214, March 2024, Page 1Author links open overlay panelHong-Xia Wang a 1, Hui Yang a 1, Qiu-Yue Han a, Nan Li a, Xue...
Corrigendum to “Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss” [Free Radic. Biol. Med. 210 (2024) 430–447]
Corrigendum to “Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss” [Free Radic. Biol. Med. 210 (2024) 430–447]
Volume 214, March 2024, Page 114Author links open overlay panelYaqi Liao a c e 1, Huanyu Mao a c e 1, Xian Gao a c e 1, Ha...
ULP-2 SUMO protease regulates UPRmt and mitochondrial homeostasis in Caenorhabditis elegans
ULP-2 SUMO protease regulates UPRmt and mitochondrial homeostasis in Caenorhabditis elegans
KeywordsSUMOSmo-1ULP-2SUMO proteaseSENPMitochondrial unfolded protein responseUPRmtAbbreviationsUPRmtMitochondrial unfolde...
Vitamin E discussion forum. Can only α-tocopherol be called vitamin E, or also other tocochromanols?
Vitamin E discussion forum. Can only α-tocopherol be called vitamin E, or also other tocochromanols?
Mariya Mykhalkiv: Writing – review & editing, Writing – original draft, Visualization, Methodology, Investigation, Dat...
Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials
Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials
Cardiovascular responses to physical exercise have been established as a valued tool for predicting cardiovascular risk an...
Aging hallmarks, biomarkers, and clocks for personalized medicine: (re)positioning the limelight
Aging hallmarks, biomarkers, and clocks for personalized medicine: (re)positioning the limelight
Volume 215, March 2024, Pages 48-55Author links open overlay panelHighlights•Aging is not a disease but predisposes to dis...
Therapeutic effect of mitochondrial transplantation on burn injury
Therapeutic effect of mitochondrial transplantation on burn injury
At least 265,000 deaths are attributed to burns and fires worldwide per year according to the World Health Organization [1...
Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-CoV-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study
Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-CoV-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study
BackgroundCoronavirus disease 2019 (COVID-19) poses an increased risk for severe illness and suboptimal vaccination respon...
Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers
Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers
Diabetes mellitus (DM) poses a substantial worldwide public health and economic challenge, being one of the most prevalent...
Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study
Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study
Carrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's dis...
Corrigendum to “Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis” [Free Radic. Biol. Med. 212 (2024) 384–402]
Corrigendum to “Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis” [Free Radic. Biol. Med. 212 (2024) 384–402]
Volume 215, March 2024, Page 1Author links open overlay panelQingquan Sun a b, Yan Wang c, Liyan Hou d, Sheng Li a, Jau-Sh...
Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis
Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis
Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is responsible ...
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation
Spontaneous subarachnoid hemorrhage (SAH), which results from the rupture of intracranial aneurysms, is a prevalent acute ...
MnO2 nanoparticles trigger hepatic lipotoxicity and mitophagy via mtROS-dependent Hsf1Ser326 phosphorylation
MnO2 nanoparticles trigger hepatic lipotoxicity and mitophagy via mtROS-dependent Hsf1Ser326 phosphorylation
In recent years, nanoparticles have been largely produced and extensively applied in various fields, such as medicine, ani...
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells
Volume 210, January 2024, Pages 406-415Author links open overlay panel, , , , , , , , , , , , Highlights•Hypercholesterole...
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
AbstractBackgroundRecent investigations have proposed a potential causal association between the occurrence of ferroptosis...
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis
Autoimmune hepatitis (AIH) is a progressive chronic liver disease characterized by elevated serum transaminases, productio...
Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway
Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway
Vitamin D3 (1,25(OH)2D3), is a naturally occurring hormone formed in a UVB-dependent, non-enzymatic reaction from the 7-de...
Astrocyte-derived hepcidin aggravates neuronal iron accumulation after subarachnoid hemorrhage by decreasing neuronal ferroportin1
Astrocyte-derived hepcidin aggravates neuronal iron accumulation after subarachnoid hemorrhage by decreasing neuronal ferroportin1
Subarachnoid hemorrhage (SAH) is a potentially life-threatening neurosurgical emergency accounting for approximately 5 % o...
Selenite ameliorates the ATP hydrolysis of mitochondrial F1FO-ATPase by changing the redox state of thiol groups and impairs the ADP phosphorylation
Selenite ameliorates the ATP hydrolysis of mitochondrial F1FO-ATPase by changing the redox state of thiol groups and impairs the ADP phosphorylation
Selenite as an inorganic form of selenium can affect the redox state of mitochondria by modifying the thiol groups of cyst...
Evaluation of the expression of genes associated with iron metabolism in peripheral blood mononuclear cells from Type 2 diabetes mellitus patients
Evaluation of the expression of genes associated with iron metabolism in peripheral blood mononuclear cells from Type 2 diabetes mellitus patients
Diabetes mellitus, a chronic, metabolic disorder characterized by insulin resistance and impaired glucose homeostasis [1],...
bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and H2O2 stress response in Schizochytrium sp.
bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and H2O2 stress response in Schizochytrium sp.
Docosahexaenoic acid (DHA, 22:6ω-3), a principal ω-3 polyunsaturated fatty acid (PUFA) of human retina and brain membranes...
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion
Hepatic ischemia/reperfusion injury (HIRI) represents a prevalent pathophysiological process that imposes a substantial ec...
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