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Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC
Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC
Despite advances in diagnosis and treatment in lung cancer, therapies still fail to improve patient management due to resi...
Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer
Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer
The objective of this study was to develop an innovative treatment strategy utilizing antisense oligonucleotides (ASOs) th...
SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer
SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer
In breast cancer, ErbB receptors play a critical role, and overcoming drug resistance remains a major challenge in the cli...
Tumor-infiltrating immune cell profiles and changes associate with additional trastuzumab in preoperative chemotherapy for patients with HER2-positive gastric cancer
Tumor-infiltrating immune cell profiles and changes associate with additional trastuzumab in preoperative chemotherapy for patients with HER2-positive gastric cancer
HER2(+) gastric cancer (GC) can benefit from trastuzumab. However, the impact of additional trastuzumab in preoperative tr...
Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies
Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies
Adiposity is a known risk factor for certain cancers; however, it is not clear whether the risk of cancer differs between ...
GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression
GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression
Mesothelioma (MESO) is an insidious malignancy with a complex diagnosis and a poor prognosis. Our study unveils Glutamine-...
Functional activation of the AKT-mTOR signalling axis in a real-world metastatic breast cancer cohort
Functional activation of the AKT-mTOR signalling axis in a real-world metastatic breast cancer cohort
Mutations of the PIK3CA/AKT/mTOR axis are common events in metastatic breast cancers (MBCs). This study was designed to ev...
Nuclear receptor TLX functions to promote cancer stemness and EMT in prostate cancer via its direct transactivation of CD44 and stem cell-regulatory transcription factors
Nuclear receptor TLX functions to promote cancer stemness and EMT in prostate cancer via its direct transactivation of CD44 and stem cell-regulatory transcription factors
Prostate cancer stem cells (PCSCs) play crucial roles in therapy-resistance and metastasis in castration-resistant prostat...
PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
Sunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to i...
DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity
DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity
Disorder of cell cycle represents as a major driver of hepatocarcinogenesis and constitutes an attractive therapeutic targ...
Identifying patients with undiagnosed small intestinal neuroendocrine tumours in primary care using statistical and machine learning: model development and validation study
Identifying patients with undiagnosed small intestinal neuroendocrine tumours in primary care using statistical and machine learning: model development and validation study
Neuroendocrine tumours (NETs) are increasing in incidence, often diagnosed at advanced stages, and individuals may experie...
Clinical landscape of macrophage-reprogramming cancer immunotherapies
Clinical landscape of macrophage-reprogramming cancer immunotherapies
Tumour-associated macrophages (TAMs) sustain a tumour-supporting and immunosuppressive milieu and therefore aggravate canc...
Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
Tolerability and antitumour efficacy of chemotherapy and radiation therapy can vary largely according to their time of adm...
Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer
Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer
Preoperative chemoradiotherapy (CRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LAR...
Joint ABS-UKCGG-CanGene-CanVar consensus regarding the use of CanRisk in clinical practice
The CanRisk tool, which operationalises the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algori...
CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas
CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas
Diffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular ...
Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers
Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers
HPV-independent cervical cancers (HPV-ind CCs) are uncommon with worse prognosis and poorly understood. This study investi...
Metabolic heterogeneity affects trastuzumab response and survival in HER2-positive advanced gastric cancer
Metabolic heterogeneity affects trastuzumab response and survival in HER2-positive advanced gastric cancer
Trastuzumab is the only first-line treatment targeted against the human epidermal growth factor receptor 2 (HER2) approved...
Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care
Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care
Interindividual pharmacokinetic variability may influence the clinical benefit or toxicity of cabozantinib in metastatic r...
Urinary microbiome-based metagenomic signature for the noninvasive diagnosis of hepatocellular carcinoma
Urinary microbiome-based metagenomic signature for the noninvasive diagnosis of hepatocellular carcinoma
Gut microbial dysbiosis is implicated in chronic liver disease and hepatocellular carcinoma (HCC), but the role of microbi...
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
Inhibition of mutant KRAS challenged cancer research for decades. Recently, allele-specific inhibitors were approved for t...
wMKL: multi-omics data integration enables novel cancer subtype identification via weight-boosted multi-kernel learning
wMKL: multi-omics data integration enables novel cancer subtype identification via weight-boosted multi-kernel learning
Cancer is a heterogeneous disease driven by complex molecular alterations. Cancer subtypes determined from multi-omics dat...
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20
The repurposing of FDA-approved drugs for anti-cancer therapies is appealing due to their established safety profiles and ...
Rethinking surgical revisions: impact of the MonarchE trial on axillary dissection in hormone-positive HER2-negative early breast cancer patients potentially eligible for abemaciclib
Rethinking surgical revisions: impact of the MonarchE trial on axillary dissection in hormone-positive HER2-negative early breast cancer patients potentially eligible for abemaciclib
The MonarchE trial explored the use of abemaciclib, a CDK4/6 inhibitor, as an adjuvant treatment in high-risk early-stage ...
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
Understanding relationships between presenting symptoms and subsequently diagnosed cancers can inform symptom awareness ca...
Epithelial ovarian cancer survival by race and ethnicity in an equal-access healthcare population
Previous studies in the general population observed that compared with non-Hispanic White women, Pacific Islander and Blac...
Correction: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial
Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, ...
Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study
Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study
Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early sta...
Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia
Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia
Alterations of FLT3 are among the most common driver events in acute leukaemia with important clinical implications, since...
Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in col...
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