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Evaluation of the Pharmacokinetic Profile of Ultra Rapid Lispro Administered Subcutaneously at Different Injection Sites
IntroductionAn important component of diabetes management to achieve an optimal glucose control, which can be measured thr...
Early Initiation of Evolocumab Treatment in Chinese Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Purpose Evolocumab has been shown to improve cardiovascular outcomes in patients with stable atheros...
Corrigendum to: “Gestational Diabetes Mellitus Is Associated with Altered Abundance of Exosomal MicroRNAs in Human Milk” [Clin Therapeut 44(2) (2022) 172-185]
Nutrition in the early postnatal period plays an important role in infant growth and the developmental programming of meta...
Comparative Efficacy and Safety of Fostemsavir in Heavily Treatment-Experienced People With HIV-1
Systematic Literature Review and Feasibility AnalysisA systematic literature review was undertaken to identify clinical tr...
Association of Dulaglutide Initiation Timing With Treatment Patterns and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus in the United States
AbstractPurposeTo describe clinical characteristics and treatment outcomes for early or late initiation of dulaglutide the...
Conversations with the Editors: Artificial Intelligence–Based Technologies Leading the Innovation in Surgical Care
Thomas Scheeren, MD, PhD: In almost 30 years of clinical activity, Dr Scheeren has worked at 3 academic university hospita...
Impact of Artificial Intelligence on Clinical Decision-Making in Health Care
In Stanley Kubrik's 1968 classic movie 2001: A Space Odyssey, H-A-L, a humanized computer more formally known as HAL 9000,...
Impact of Methotrexate Discontinuation, Interruption, or Persistence in US Patients with Rheumatoid Arthritis Initiating Tofacitinib + Oral Methotrexate Combination
Purpose Using data from real-world practice, this analysis compared outcomes in patients with rheuma...
The Impact of Mandatory Nonmedical Switching From Originator to Biosimilar Insulin Glargine
American Diabetes AssociationEconomic costs of diabetes in the U.S. in 2017.Diabetes Care. 41: 917-928The cost of diabetes...
Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis
Purpose The purpose of this meta-analysis was to assess the effect of statins on major adverse cardi...
Toward Kidney-Specific Causality Assessment Tool
Anatomy and physiology of the kidney.AORN J. 68: 799-820Kidney Function.Clinical Biochemistry of Domestic Animals. Fifth E...
Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers
Diabetes and hypertension: the bad companions.Lancet Lond Engl. 380: 601-610Correction to: diabetes, cardiovascular diseas...
Vedolizumab as the First-Line of Biologicals for Pediatric Patients With Ulcerative Colitis
Purpose Vedolizumab (VDZ) was reported to be effective as a first-line biological in adult ulcerativ...
Pharmacokinetic Interactions Between Tegoprazan and Naproxen, Aceclofenac, and Celecoxib in Healthy Korean Male Subjects
Purpose Tegoprazan is a potassium-competitive acid blocker used for gastric acid suppression and may...
Cooperation Agreements, Memorandums of Understanding, and Letters of Intent as Instruments to Facilitate the Implementation of Reliance in Latin America
ANVISA-Brazil; BRICS (Brazil, Russia, India, China), 2019 (MOU between the BRICS health regulatory authorities; http://bri...
Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review
Treating hypogonadism in younger males.Expert Opin Pharmacother. 11: 1529-1540Yeap BB Grossmann M McLachlan RI et al.Endoc...
Lipids, Lipid-Lowering Therapy, and Neuropathy: A Narrative Review
Prescribing statins to reduce cardiovascular disease: 10 common misconceptions.Am J Med. 132: 897-899Collins R Reith C Emb...
Acute Myocarditis Following Methimazole: A Case Report
Hyperthyroidism is an endocrine disorder characterized by hypermetabolism and increased excitability of multiple org...
Ivermectin for coronavirus disease 2019: Yet to be well evaluated before clinical use
Dear EditorWe read with great interest the recent paper published by Shahbaznejad et al. regarding the effectiveness of iv...
Pharmacokinetics of a New, Once-Daily, Sustained-Release Pregabalin Tablet in Healthy Male Volunteers
Center for Clinical Pharmacology and Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic...
Health-Related Quality of Life Among Patients With HR+/HER2– Early Breast Cancer
Bray F. Ferlay J. Soerjomataram I. Siegel R.L. Torre L.A. Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of in...
Retrospective Analysis of Disease Severity, Health Care Resource Utilization, and Costs Among Patients Initiating Belimumab for the Treatment of Systemic Lupus Erythematosus
ABSTRACTPurposeThe goal of this study was to evaluate clinical and economic outcomes associated with the initiation of int...
Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Tegoprazan
Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, Seoul, KoreaPharmacometrics Institute for...
Risk of thromboembolic events and associated risk factors, including treatments, in patients with immune-mediated diseases
IntroductionImmune-mediated diseases (IMDs) are a heterogeneous group that comprise >100 chronic and often debilitating...
Running the Obstacle Course: Improving the Utilization of Bariatric Surgery in Adolescent Obesity
Hales C.M. Carroll M.D. Fryar C.D. Ogden C.L. Prevalence of obesity among adults and youth: United States, 2015-2016.NCHS ...
Obesity 2021: Rejecting Old Misconceptions and Embracing a New Paradigm to Improve Outcomes
Hales CM Carroll MD Fryar CD Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017-2018.NCH...
Our Response to the Obesity Crisis Reflects Our Bias as a Society
This month's issue of Clinical Therapeutics highlights the topic of obesity as a public health issue to which we, as a med...
First-line Daratumumab in Addition to Chemotherapy for Newly Diagnosed Multiple Myeloma Patients Who are Transplant Ineligible: A Cost-Effectiveness Analysis
Purpose Daratumumab is a standard-of-care treatment for newly diagnosed multiple myeloma (NDMM). Acc...
Quantifying the Burden of Hyperphagia in Prader-Willi Syndrome Using Quality-Adjusted Life-years
EQ-5D for the assessment of health-related quality of life and resource allocation in children: a systematic methodologica...
Justification of the Subcutaneous Mepolizumab Dose of 300 mg in Eosinophilic Granulomatosis With Polyangiitis and Hypereosinophilic Syndrome
Key wordsIntroductionThis communication provides the justification supporting the selection of the mepolizumab 300 mg subc...
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