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Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses
Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses
The escalating global burden of cardiovascular diseases is a growing concern. Numerous research studies have established t...
Cardioprotective effects of GPER agonist in ovariectomized diabetic rats: reversing ER stress and structural changes
Cardioprotective effects of GPER agonist in ovariectomized diabetic rats: reversing ER stress and structural changes
The incidence of diabetic cardiomyopathy (DCM) significantly increases in postmenopausal women, suggesting protective role...
Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis
Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis
New methods are essential to characterize the performance of substitute procedures for detecting therapeutic action(s) of ...
Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway
Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal dysfunction. Cimifugin is an active component of Radix sapo...
Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice
Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice
The persistent symptoms of anxiety, depression, and fatigue that follow severe acute respiratory syndrome coronavirus 2 in...
Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence
Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence
Previous research from our group revealed a strong association between daily defined dose (DDD)-costs and -prescriptions o...
Insufficient correctness of package inserts for psychotropic drugs in Germany
Insufficient correctness of package inserts for psychotropic drugs in Germany
Package inserts often cause displeasure among patients as they are perceived as misleading and confusing. The aim of this ...
A comprehensive review on physiological and biological activities of carnosine: turning from preclinical facts to potential clinical applications
A comprehensive review on physiological and biological activities of carnosine: turning from preclinical facts to potential clinical applications
Carnosine, a compound with plethora of benefits, was originally discovered in 1900 and is formed by the amide linkage of &...
Potential promising of synthetic lethality in cancer research and treatment
Potential promising of synthetic lethality in cancer research and treatment
Cancer is a complex disease driven by multiple genetic changes, including mutations in oncogenes, tumor suppressor genes, ...
Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review
Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review
Resveratrol (RV—3, 5, 4′‐trihydroxystilbene) is a natural compound found in plants like red grapes, berr...
The effects of self-assembling peptide on glial cell activation
The effects of self-assembling peptide on glial cell activation
Glial cells play a critical role in the healthy and diseased phases of the central nervous system (CNS). CNS diseases invo...
Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation
Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation
Slow transit constipation (STC) seriously affects the physical and mental health of patients. While the active ingredients...
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
Ankylosing spondylitis (AS) is a chronic inflammatory joint disease, which can result in disability in severe cases and en...
Identification of the active constituents and molecular mechanism of Eulophia nuda extract in the treatment of osteoarthritis by network pharmacology, molecular modelling and experimental assays
Identification of the active constituents and molecular mechanism of Eulophia nuda extract in the treatment of osteoarthritis by network pharmacology, molecular modelling and experimental assays
Osteoarthritis is a degenerative joint disease that worsens over time, often resulting in chronic pain. Eulophia nuda (Orc...
Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients: a randomized, double-blinded, placebo-controlled, pilot clinical trial
Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients: a randomized, double-blinded, placebo-controlled, pilot clinical trial
Nephrotoxicity is one of the most common complications of vancomycin use in clinical practice. Silymarin has potential to ...
Antibacterial and antibiofilm activities of bacteriocin produced by a new strain of Enterococcus faecalis BDR22
Antibacterial and antibiofilm activities of bacteriocin produced by a new strain of Enterococcus faecalis BDR22
A large number of recalcitrant bacterial pathogens cannot be easily treated by antibiotics due to the existence of biofilm...
Recent advancements in improving the efficacy and safety of chimeric antigen receptor (CAR)-T cell therapy for hepatocellular carcinoma
Recent advancements in improving the efficacy and safety of chimeric antigen receptor (CAR)-T cell therapy for hepatocellular carcinoma
The liver is one of the most frequent sites of primary malignancies in humans. Hepatocellular carcinoma (HCC) is one of th...
Study on the mechanism of activating SIRT1/Nrf2/p62 pathway to mediate autophagy-dependent ferroptosis to promote healing of diabetic foot ulcers
Study on the mechanism of activating SIRT1/Nrf2/p62 pathway to mediate autophagy-dependent ferroptosis to promote healing of diabetic foot ulcers
Diabetic foot (DF), a prevalent and grave diabetes sequela, is considered as a notable clinical concern, with SIRT1 downre...
Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway
Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway
Dexpanthenol (DEX), a subtype of vitamin B5, plays an important role in anabolic reactions, cellular energy and regenerati...
Ex vivo treatment with poly (I:C) alleviates the exhausted phenotype of tumor-infiltrating TCD8+ cells of gastric cancer patients
Ex vivo treatment with poly (I:C) alleviates the exhausted phenotype of tumor-infiltrating TCD8+ cells of gastric cancer patients
Gastric cancer is associated with the phenotypic and functional exhaustion of TCD8+ cells. On the other hand, Toll-like re...
Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine
Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine
Hyperthyroidism is associated with the alteration in molecular pathways involved in the regulation of mitochondrial mass a...
Retraction Note: Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice
Retraction Note: Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice
Pharmacological Sciences Research Laboratory, Department of Pharmacy, Faculty of Biological Sciences, Quaid-I-Azam Univers...
Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs
Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs
The microbiome is increasingly implicated in playing a role in physiology and pharmacology; in this review, we investigate...
Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway
Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway
Clinically, thymoma patients are often complicated with myasthenia gravis (MG). Dexamethasone, a glucocorticoid with anti-...
Phytochemical studies of white mulberry fruits (Morus alba L.)
Phytochemical studies of white mulberry fruits (Morus alba L.)
Medicinal preparations made from plant materials have been widely used for many years due to their high pharmacological ef...
Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Despite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. ...
Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway
Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway
Retinoblastoma is a prevalent pediatric intraocular tumor. The suppressive effect of gentiopicroside (GPS) has been report...
Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress
Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress
Ulcerative colitis is an intestinal inflammatory condition characterized by a rise in inflammatory mediator production and...
Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Network pharmacology and bioinformatics were used to study puerarin’s molecular mechanism in treating osteoarthritis...
Assessment of antibacterial drug utilization patterns and antibiogram in infectious diseases: a prospective cross-sectional study
Assessment of antibacterial drug utilization patterns and antibiogram in infectious diseases: a prospective cross-sectional study
Antibacterial drugs are successful in combating most types of infections. Irrational use and higher consumption of these d...
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