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Expression of Concern: The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins
Following the publication and subsequent Correction of this article [1, 2], concerns were raised re...
Unraveling how the third-party brain under stress responds to injustices
How third-party individuals respond to injustices is important for resolving conflict in society. This Primer explores a n...
Understanding pathophysiology of GNE myopathy and current progress towards drug development
Understanding pathophysiology of GNE myopathy and current progress towards drug development
GNE myopathy is a rare genetic neuromuscular disease that is caused due to mutations in the GNE gene responsible for siali...
Orphan drug development: Challenges, regulation, and success stories
Orphan drug development: Challenges, regulation, and success stories
Rare diseases, also known as orphan diseases, are diseases with low occurrence in the population. Developing orphan drugs ...
mRNA biotherapeutics landscape for rare genetic disorders
mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-...
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Gaucher disease (GD) is a prevalent lysosomal storage disorder (LSD) that significantly impacts individuals’ lives. ...
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy (SMA) is a neuromuscular, rare genetic disorder caused due to loss-of-function mutations in the su...
Recent developments in gene therapy research in India
Recent developments in gene therapy research in India
Inherited genetic disorders are progressive in nature and lead to organ dysfunction or death in severe cases. At present, ...
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Multiple endocytic processes operate in cells in tandem to uptake multiple cargoes involved in diverse cellular functions,...
Finding identical sequence repeats in multiple protein sequences: An algorithm
Finding identical sequence repeats in multiple protein sequences: An algorithm
In recent years, several experimental evidences suggest that amino acid repeats are closely linked to many disease conditi...
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Snake venom L-amino acid oxidases (LAAOs) are flavoenzymes with diverse physiological and pharmacological effects. These e...
Crosstalk between photosynthesis and respiration in microbes
Crosstalk between photosynthesis and respiration in microbes
Phototrophic organisms harbor two main bioenergetic hubs, photosynthesis and respiration, and these processes dynamically ...
Role of mitochondria and chloroplasts during stomatal closure: Subcellular location of superoxide and H2O2 production in guard cells of Arabidopsis thaliana
Role of mitochondria and chloroplasts during stomatal closure: Subcellular location of superoxide and H2O2 production in guard cells of Arabidopsis thaliana
Stomatal guard cells are unique in that they have more mitochondria than chloroplasts. Several reports emphasized the impo...
From sequence to consequence: Deciphering the complex cis-regulatory landscape
From sequence to consequence: Deciphering the complex cis-regulatory landscape
Cell type-specific expression of genes plays a pivotal role in the development and evolution of multicellular organisms ov...
Tumor cell type and gene marker identification by single layer perceptron neural network on single-cell RNA sequence data
Tumor cell type and gene marker identification by single layer perceptron neural network on single-cell RNA sequence data
Tumors have drawn increasing attention recently because of their heterogeneous interior structures. Particularly, single-c...
Visual plant anatomy: From science to education and vice versa
Visual plant anatomy: From science to education and vice versa
Plant biology, mainly plant anatomy, is a less attractive area for students at high school and university, but not much re...
A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis
A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis
We investigated the relationship between neutrophil apoptosis and endoplasmic reticulum stress (ERS) in sepsis and its mec...
Predicting and reducing potential parasite infection between migratory livestock and resident Asiatic ibex of Pin valley, India
Predicting and reducing potential parasite infection between migratory livestock and resident Asiatic ibex of Pin valley, India
Disease cross-transmission between wild and domestic ungulates can negatively impact livelihoods and wildlife conservation...
Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. O...
ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case
ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case
Helsmoortel–Van der Aa syndrome is a neurodevelopmental disorder in which patients present with autism, intellectual...
BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion
BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion
Methylation class “CNS tumor with BCOR/BCOR(L1)-fusion” was recently defined based on methylation profiling an...
Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the hi...
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
We recently reported that phogrin, also known as IA-2β or PTPRN2, forms a complex with the insulin receptor in pancre...
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c...
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Key reproductive events such as fertilization and early embryonic development occur in the lumen of the oviduct. Since inv...
Optimization of PAS stain and similar Schiff’s based methods for glycogen demonstration in liver tissue
Optimization of PAS stain and similar Schiff’s based methods for glycogen demonstration in liver tissue
Demonstration of glycogen in tissue holds considerable diagnostic relevance across various pathological conditions, partic...
JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes
JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes
c-Jun NH2-terminal protein kinase (JNK) and p38 are stress-activated mitogen-activated protein kinases (MAPK) that are pho...
Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
The third most prevalent malignancy to cause mortality is hepatocellular carcinoma (HCC). The Hedgehog (Hh) signaling path...
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy, tumor heterogeneity remains a formi...
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