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Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases
Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases
KeywordsInherited retinal dystrophiesNR2E3Photoreceptor differentiationRetinal developmentSingle-cell RNA-seqAbbreviations...
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Pathogenic variants in KCNB1 are associated with a neurodevelopmental disorder spectrum that includes global developmental...
Deciphering the shift from benign to active relapsing-remitting multiple sclerosis: Insights into T regulatory cell dysfunction and apoptosis regulation
Deciphering the shift from benign to active relapsing-remitting multiple sclerosis: Insights into T regulatory cell dysfunction and apoptosis regulation
BackgroundRelapsing-remitting multiple sclerosis (RRMS), a common demyelinating disease among young adults, follows a beni...
Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy
Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy
A growing number of clinical and animal studies suggest that the nucleus accumbens (NAc), especially the shell, is involve...
Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus
Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus
ObjectiveOlfactory dysfunction indicates a higher risk of developing dementia. However, the potential structural and funct...
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
KeywordsEngrailed 1dopaminergic neuronprimary ciliaWnt signalinginduced pluripotent stem cellscomplex Imitochondrial respi...
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
Volume 194, May 2024, 106473Author links open overlay panel, , , , , , , Highlights•The amyloid β-mediated vicious cycle o...
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
Pyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntin...
Corrigendum to “Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy” [Neurobiology of Disease 127 (2019) 362–373]
Corrigendum to “Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy” [Neurobiology of Disease 127 (2019) 362–373]
Volume 194, May 2024, 106479Author links open overlay panelSudipta Chakrabarti a, Sujyoti Chandra a, Avik Roy a b, Madhuch...
Corrigendum to “Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy” [Neurobiology of Disease 136 (2020) 104715]
Corrigendum to “Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy” [Neurobiology of Disease 136 (2020) 104715]
Volume 194, May 2024, 106480Author links open overlay panelLi-Tao Yi a b c, Shu-Qi Dong a, Shuang-Shuang Wang a, Min Chen ...
Sex-specific vulnerabilities in human astrocytes underpin the differential impact of palmitic acid
Sex-specific vulnerabilities in human astrocytes underpin the differential impact of palmitic acid
Obesity and neurometabolic diseases have been linked to neurodegenerative diseases. Our hypothesis is that the endogenous ...
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Microglia contribute to the outcomes of various pathological conditions including Parkinson's disease (PD). Microglia are ...
Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata
Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata
KeywordsSTNSNrOddballNoveltySurpriseAttentionMicro electrode recordingDBSParkinson's diseaseAbbreviationsSNrSubstantia Nig...
Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia
Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia
We performed a comprehensive study of the morphological, functional, and genetic features of moonwalker (MWK) mice, a mous...
Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington's disease
Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington's disease
Given their highly polarized morphology and functional singularity, neurons require precise spatial and temporal control o...
Aberrant dynamic functional network connectivity in progressive supranuclear palsy
Aberrant dynamic functional network connectivity in progressive supranuclear palsy
KeywordsProgressive supranuclear palsyDynamic functional network connectivityCerebellum networkDefault mode networkSubcort...
Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy
Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy
KeywordsAminoacyl-tRNA synthetase (ARS)Charcot-Marie-tooth disease (CMT)Intravital imagingMotor neuronNeuromuscular juncti...
Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice
Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice
KeywordsFragile X syndromeAutism spectrum disordersElectroencephalographyBiomarkerAuditory cortexSensory hypersensitivityE...
CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia
CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia
KeywordsCHCHD10MitochondrionFrontotemporal dementiaAmyotrophic lateral sclerosisMouse modelAbbreviationsIba1Actin-binding ...
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
KeywordsGut-brain axisSepsis-associated encephalopathyVagus nerveNeuroendocrineNeuroimmuneAbbreviationsACTHadrenocorticotr...
Harmonization of CSF and imaging biomarkers for Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification
Harmonization of CSF and imaging biomarkers for Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification
In Alzheimer's disease (AD) research, cerebrospinal fluid (CSF) Amyloid beta (Aβ), Tau and pTau are the most accepted and ...
The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study
The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study
Keywords7 T MRIThalamusCerebral small vessel diseasePosterior cerebral arteryGaitAbbreviationsAAL3automated anatomical lab...
Differential profiles of serum cytokines in Parkinson's disease according to disease duration
Differential profiles of serum cytokines in Parkinson's disease according to disease duration
ObjectiveNeurodegeneration and neuroinflammation are two intertwined mechanisms contributing to the pathophysiology of Par...
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, for...
Predicting neurodegeneration from sleep related biofluid changes
Predicting neurodegeneration from sleep related biofluid changes
Sleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potent...
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
KeywordsHuntington diseaseYAC128 miceAntisense oligonucleotidesCaspase-6RNA splicingRNA sequence analysisMRIAbbreviationsa...
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
KeywordsNeurodegenerationX-linked dystonia parkinsonism diseaseInduced pluripotent stem cellsMedium spiny neuronsQuantitat...
External segment of the globus pallidus in health and disease: Its interactions with the striatum and subthalamic nucleus
External segment of the globus pallidus in health and disease: Its interactions with the striatum and subthalamic nucleus
KeywordsExternal segment of the globus pallidusStriatumSubthalamic nucleusParkinson's diseaseMovement disordersDeep brain ...
Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6
Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6
KeywordsPrion diseaseCreutzfeldt-Jakob diseaseSNARESyntaxin-6Incubation periodAbbreviationssCJDsporadic Creutzfeldt-Jakob ...
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
Gangliogliomas (GGs) represent the most frequent glioneuronal tumor entity associated with chronic recurrent seizures; rar...
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