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Pathological Roles for Endothelial Colony-Forming Cells in Neonatal and Adult Lung Disease
Endothelial colony-forming cells (ECFCs) are vascular resident and circulating endothelial cell subtypes with potent angio...
Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis
The gain-of-function minor allele of the MUC5B (mucin 5B, oligomeric mucus/gel-forming) promoter (rs35705950) is the stron...
USP13 Deficiency Impairs Autophagy and Facilitates Age-related Lung Fibrosis
Idiopathic pulmonary fibrosis (IPF) is an age-related disease. Failure of the proteostasis network with age, including ins...
IFN-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury
The mechanisms by which excessive systemic activation of adaptive T lymphocytes, as in cytokine release syndrome (CRS), le...
Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated Mucosal-associated Invariant T-Cell Activation
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8+ T lymp...
Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice
ERK1/2 (extracellular signal-regulated kinases 1 and 2) regulate the activity of various transcription factors that contri...
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension
Mitochondrial fission and a metabolic switch from oxidative phosphorylation to glycolysis are key features of vascular pat...
Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation–Contraction Coupling
Bronchomotor tone modulated by airway smooth muscle shortening represents a key mechanism that increases airway resistance...
Dysregulation of miR-103a Mediates Cigarette Smoking–induced Lipid-laden Macrophage Formation
Cigarette smoke (CS) is considered a major risk factor for chronic obstructive pulmonary disease (COPD) that is currently ...
Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease
Phenotypic alterations in the lung epithelium have been widely implicated in chronic obstructive pulmonary disease (COPD) ...
Intestinal Microbiota-derived Propionic Acid Protects against Zinc Oxide Nanoparticle–induced Lung Injury
With the rapid development of nanotechnology, the risks of accidental and/or occupational exposure to zinc oxide nanoparti...
Leptin-loaded Extracellular Vesicles Treat Sleep-disordered Breathing in Mice with Obesity
Supported by the National Institutes of Health/National Heart, Lung, Blood Institute grants: NIH/NHLBI R01HL128970 (V.Y.P....
Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease
Endothelial-to-mesenchymal transition (EndMT) plays a critical role in the flow-induced vascular remodeling process, such ...
Myeloid- and Epithelial-derived Heparin-Binding Epidermal Growth Factor-like Growth Factor Promotes Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a poorly understood, progressive lethal lung disease with no known cure. In additio...
Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity
Chronic beryllium disease (CBD) is a Th1 granulomatous lung disease preceded by sensitization to beryllium (BeS). We profi...
Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition
Neuropeptide Y (NPY), a 36 amino acid residue polypeptide distributed throughout the nervous system, acts on various immun...
Cryobanking of Human Distal Lung Epithelial Cells for Preservation of Their Phenotypic and Functional Characteristics
The epithelium lining airspaces of the human lung is maintained by regional stem cells, including basal cells of pseudostr...
Elexacaftor/Tezacaftor/Ivacaftor Disrupts Respiratory Tract Development in a Murine Fetal Lung Explant Model
Author Contributions: Conception and design: I.S.-G. and A.H. Experiments: M.L., L.A., E.D., M.-L.F.-M., K.L.-T., and N.H....
Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19
Coronavirus disease (COVID-19) begins with upper airway symptoms but proceeds in a significant proportion of patients to l...
Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development
Pulmonary hypertension (PH) is a multifaceted condition characterized by elevated pulmonary arterial pressure, which can r...
CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages
Rapid and effective control of bacterial infection is critical for the treatment of bacterial sepsis. CXCL14 (CXC motif li...
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice
Ozone (O3)-induced respiratory toxicity varies considerably within the human population and across inbred mouse strains, i...
PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells
G protein–coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be...
m6A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling induced by human pulmonary arteria...
Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma
Activation of IL-4R (IL-4 receptor) signaling in airway epithelial cells leads to airway hyperresponsiveness and mucus ove...
The Role of Glutathione Reductase in Influenza Infection
Influenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has ...
New Insights Relating Gasdermin B to the Onset of Childhood Asthma
Chromosome 17q12-q21 is the most replicated genetic locus for childhood-onset asthma. Polymorphisms in this locus containi...
Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
"Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease ...
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization
Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway...
A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH
"A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH." American Journal of Respiratory Cell and Molecular Bio...
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