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Treatment and prognostic implications of strong PD-L1 expression in primary hepatic sarcomatoid carcinoma
Treatment and prognostic implications of strong PD-L1 expression in primary hepatic sarcomatoid carcinoma
Primary hepatic sarcomatoid carcinoma (HSC) is an extremely rare and aggressive subtype of primary liver cancer. HSC has u...
Facilitated subcutaneous immunoglobulin treatment patterns in pediatric patients with primary immunodeficiency diseases
Facilitated subcutaneous immunoglobulin treatment patterns in pediatric patients with primary immunodeficiency diseases
Aim: This retrospective study investigated real-world hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) treatm...
Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis
Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis
Aim: To explore the association between sex and immune checkpoint inhibitors (ICIs). Materials & methods: We assessed ...
A rare case of daratumumab-associated encephalopathy in multiple myeloma
A rare case of daratumumab-associated encephalopathy in multiple myeloma
Aim: Daratumumab, a CD38 monoclonal antibody, has been widely used in patients with multiple myeloma. Although a variety o...
Metastatic gastric cancer: synergizing and sequencing targeted therapy with first-line immunotherapy
Metastatic gastric cancer: synergizing and sequencing targeted therapy with first-line immunotherapy
The authors have no financial involvement with any organization or entity with a financial interest in or financial confli...
Outcomes for pembrolizumab stratified by pemetrexed maintenance post pembrolizumab–platinum–pemetrexed induction in metastatic non-small-cell lung cancer
Outcomes for pembrolizumab stratified by pemetrexed maintenance post pembrolizumab–platinum–pemetrexed induction in metastatic non-small-cell lung cancer
Aim: We assessed treatment patterns and outcomes in patients with metastatic nonsquamous non-small-cell lung cancer (mNSCL...
Pembrolizumab in patients from China with microsatellite instability-high/mismatch repair deficient tumors: KEYNOTE-158
Pembrolizumab in patients from China with microsatellite instability-high/mismatch repair deficient tumors: KEYNOTE-158
Aim: To evaluate pembrolizumab in patients of Chinese descent with microsatellite instability-high (MSI-H)/deficient misma...
The role of ixekizumab in the treatment of nonradiographic axial spondyloarthritis
The role of ixekizumab in the treatment of nonradiographic axial spondyloarthritis
Nonradiographic axial spondyloarthritis (nr-axSpA) is a subtype of SpA with undeveloped definite radiographic sacroiliitis...
Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?
Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?
Aim: This study aims to clarify the efficacy and adverse effects of immune checkpoint inhibitors (ICIs) in the lung cancer...
Certolizumab pegol in the treatment of axial spondyloarthritis
Certolizumab pegol in the treatment of axial spondyloarthritis
Axial spondyloarthritis is a chronic, immune-mediated systemic inflammatory disease encompassing ankylosing spondylitis an...
Sintilimab-induced severe erosive hemorrhagic gastritis and pyloric obstruction: a case report and literature review
Sintilimab-induced severe erosive hemorrhagic gastritis and pyloric obstruction: a case report and literature review
Immune checkpoint inhibitors could restore immune surveillance to attack tumor through targeting CTLA-4, PD-1 or PD-L1, an...
Effectiveness of allergen immunotherapy with house dust mite extract for pediatric bronchial asthma
Effectiveness of allergen immunotherapy with house dust mite extract for pediatric bronchial asthma
Aim: We compared the effectiveness of rush subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) using sta...
Serplulimab monotherapy in extensive-stage small-cell lung cancer with brain metastasis: a case report
Serplulimab monotherapy in extensive-stage small-cell lung cancer with brain metastasis: a case report
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with limited treatment options, especially for extensiv...
Prognostic value of peripheral blood neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pan-immune-inflammation value and systemic immune-inflammation index for the efficacy of immunotherapy in patients with advanced gastric cancer
Prognostic value of peripheral blood neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pan-immune-inflammation value and systemic immune-inflammation index for the efficacy of immunotherapy in patients with advanced gastric cancer
Aim: The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymp...
Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease
Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease
Risankizumab is a humanized monoclonal antibody that inhibits the p19 subunit of IL-23 cytokine. Recently it has been appr...
Adherence, persistence and treatment switching in psoriasis
Adherence, persistence and treatment switching in psoriasis
Aim: This study aims to investigate drug utilization patterns in the treatment of psoriasis (PsO) from 1 to 5 years in a r...
What is the future of immune checkpoints inhibitors for metastatic triple negative breast cancers?
What is the future of immune checkpoints inhibitors for metastatic triple negative breast cancers?
*CONTACT: E-mail Address: ramondemello@gmail.comhttps://orcid.org/0000-0002-9640-4573Department of Oncology, Oxford Cancer...
Clinical course and management of pembrolizumab-associated isolated adrenocorticotrophic hormone deficiency: a new case and literature review
Hypophysitis is rarely reported in patients receiving pembrolizumab-only immunotherapies. Since the clinical presentation ...
Atherosclerosis: immunopathogenesis and strategies for immunotherapy
Atherosclerosis, a chronic inflammatory condition in which atheroma accumulates within the intima of the arterial wall, is...
Anti-PD-1 and regorafenib induce severe multisystem adverse events in microsatellite stability metastatic colorectal cancer: a case report
There exists a dilemma in the treatment of microsatellite stability (MSS) metastatic colorectal cancer (mCRC) owing to lim...
Durable response after immune checkpoint inhibitor-related diabetes in mismatch repair deficient pancreatic cancer
Mismatch repair protein deficiency occurs in 0.8–2% of pancreatic ductal adenocarcinomas and confers susceptibility to imm...
Real-world treatment patterns and outcomes in PD-L1-positive non-small cell lung cancer
Aim: We report real-world treatment patterns and outcomes in patients with PD-L1+ non-small cell lung cancer (NSCLC). Meth...
Patient needs and benefits of sublingual immunotherapy for grass pollen-induced allergic rhinitis: an observational study
Aim: Clinical efficacy of sublingual immunotherapy for grass pollen-induced allergic rhinitis (AR) needs to translate into...
Pretreatment lung immune prognostic index as a biomarker in advanced non-small-cell lung cancer patients receiving first line pembrolizumab
Background: To investigate the role of pretreatment lung immune prognostic index (LIPI) as biomarker in PD-L1 ≥50% non-sma...
Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review
Aim: Cytokine release syndrome (CRS) is an infrequently described immune-related adverse event of checkpoint inhibitors (C...
Chemotherapy or chemo-immunotherapy as first-line treatment for extensive-stage small-cell lung cancer – a meta-analysis
This meta-analysis investigated the clinical benefits of chemo-immunotherapy in extensive-stage small-cell lung cancer (ES...
Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab
Leptomeningeal disease (LMD) is a complication of metastasized melanoma, with poor prognosis even in the era of immunother...
Enteric plexus neuropathy associated with PD-L1 blockade in a patient with small-cell lung cancer
Immune checkpoint inhibitors have revolutionized the management of patients with cancer. The increasing use of these agent...
TYK2 as a therapeutic target in the treatment of autoimmune and inflammatory diseases
JAKs are intracellular protein tyrosine kinases that, through activation of STATs, are responsible for signal transduction...
Volume increase of spleen in melanoma patients undergoing immune checkpoint blockade
Aim: To find out whether treatment with immune checkpoint inhibitors (ICIs) results in volume increase of the spleen. Pati...
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