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C1QBP regulates T cells mitochondrial fitness to affect their survival, proliferation and anti‐tumor immune function
C1QBP regulates T cells mitochondrial fitness to affect their survival, proliferation and anti‐tumor immune function
Abstract T cells survival, proliferation and anti-tumor response are tightly linked to their mitochondrial health. Complem...
The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by accumulation of immature cells i...
ErbB4‐mediated regulation of vasculogenic mimicry capability in breast cancer cells
ErbB4‐mediated regulation of vasculogenic mimicry capability in breast cancer cells
Abstract ErbB4 is a member of the ErbB receptor tyrosine kinase family. It has both pro- and anti-oncogenic activities in ...
High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis
High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis
Abstract Myxoid liposarcoma (MLPS) is genetically characterized by FUS-DDIT3 or EWSR1-DDIT3 gene fusion and high frequency...
Cancer immunotherapy using artificial adjuvant vector cells to deliver NY‐ESO‐1 antigen to dendritic cells in situ
Cancer immunotherapy using artificial adjuvant vector cells to deliver NY‐ESO‐1 antigen to dendritic cells in situ
Abstract NY-ESO-1 is a cancer/testis antigen expressed in various cancer types. However, the induction of NY-ESO-1-specifi...
Oncogenic FGFR1 mutation and amplification in common cellular origin in a composite tumor with neuroblastoma and pheochromocytoma
Oncogenic FGFR1 mutation and amplification in common cellular origin in a composite tumor with neuroblastoma and pheochromocytoma
Abstract Neuroblastoma (NB) and pheochromocytoma (PCC) are derived from neural crest cells (NCCs); however, composite tumo...
Development of an in vitro carcinogenesis model of human papillomavirus‐induced cervical adenocarcinoma
Development of an in vitro carcinogenesis model of human papillomavirus‐induced cervical adenocarcinoma
Abstract Cervical adenocarcinoma (ADC) is the second most common pathological subtype of cervical cancer after squamous ce...
Prognostic impact of circulating tumor cells detected with the microfluidic “Universal CTC‐chip” for primary lung cancer
Prognostic impact of circulating tumor cells detected with the microfluidic “Universal CTC‐chip” for primary lung cancer
Abstract Detecting rare circulating tumor cells (CTCs) in the bloodstream is extremely challenging. We had previously deve...
An aging‐related signature predicts favorable outcome and immunogenicity in lung adenocarcinoma
An aging‐related signature predicts favorable outcome and immunogenicity in lung adenocarcinoma
Abstract Aging has been demonstrated to play vital roles in the prognosis and treatment efficacy of cancers, including lun...
Next‐generation sequencing of endoscopically obtained tissues from patients with all stages of pancreatic cancer
Next‐generation sequencing of endoscopically obtained tissues from patients with all stages of pancreatic cancer
Abstract Routinely available clinical samples of all stages of pancreatic cancer could be used to elucidate its molecular ...
Nanomedicine Targets Iron Metabolism for Cancer Therapy
Nanomedicine Targets Iron Metabolism for Cancer Therapy
Abstract Iron is an essential element for cell proliferation and homeostasis via engaging in cell metabolism including DNA...
A prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1
A prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1
Abstract We conducted genomic analyses of Japanese patients with stage I esophageal squamous cell carcinoma (ESCC) to inve...
A modified MethyLight assay predicts the clinical outcomes of anti‐EGFR treatment in metastatic colorectal cancer
A modified MethyLight assay predicts the clinical outcomes of anti‐EGFR treatment in metastatic colorectal cancer
Abstract The DNA methylation status correlates with clinical outcomes of anti-epidermal growth factor receptor (EGFR) trea...
Identification of an IDO1‐based immune classifier for survival prediction of upper tract urothelial carcinoma
Identification of an IDO1‐based immune classifier for survival prediction of upper tract urothelial carcinoma
Abstract The limited response rate of immunotherapy in upper tract urothelial carcinoma (UTUC) might be attributed to addi...
PolyI:C attenuates transforming growth factor‐β signaling to induce cytostasis of surrounding cells by secreted factors in triple‐negative breast cancer
PolyI:C attenuates transforming growth factor‐β signaling to induce cytostasis of surrounding cells by secreted factors in triple‐negative breast cancer
Abstract The activation of RIG-I-like receptor (RLR) signaling in cancer cells is widely recognized as a critical cancer t...
Thrombospondin‐1 induced programmed death‐ligand 1‐mediated immunosuppression by activating the STAT3 pathway in osteosarcoma
Thrombospondin‐1 induced programmed death‐ligand 1‐mediated immunosuppression by activating the STAT3 pathway in osteosarcoma
Abstract Thrombospondin-1 (TSP1) is generally assumed to suppress the growth of osteosarcoma through inhibiting angiogenes...
hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis
hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis
Abstract Noncoding RNAs have been verified to regulate the infiltration of macrophages to accelerate tumor biological prog...
FDFT1 predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes SQLE to promote tumor progression
FDFT1 predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes SQLE to promote tumor progression
Abstract Colon adenocarcinoma (COAD) is one of the most prevalent malignancies, with poor prognosis and lack of effective ...
Phase 1/2 Study Evaluating the Safety and Efficacy of DSP‐7888 Dosing Emulsion in Myelodysplastic Syndromes
Phase 1/2 Study Evaluating the Safety and Efficacy of DSP‐7888 Dosing Emulsion in Myelodysplastic Syndromes
Abstract DSP-7888 is an immunotherapeutic cancer vaccine derived from the Wilms’ tumor gene 1 (WT1) protein. This p...
Development of an in vitro carcinogenesis model of HPV induced cervical adenocarcinoma
Development of an in vitro carcinogenesis model of HPV induced cervical adenocarcinoma
Abstract Cervical adenocarcinoma is the second most common pathological subtype of cervical cancer after squamous cell car...
Enforced DYRK2 expression by adenovirus‐mediated gene transfer inhibits tumor growth and metastasis of colorectal cancer
Enforced DYRK2 expression by adenovirus‐mediated gene transfer inhibits tumor growth and metastasis of colorectal cancer
Abstract Colorectal cancer is one of the most common gastrointestinal tumors with good outcomes, but when it has distant m...
FZD10‐targeted α‐radioimmunotherapy with 225Ac‐labeled OTSA101 achieves complete remission in a synovial sarcoma model
FZD10‐targeted α‐radioimmunotherapy with 225Ac‐labeled OTSA101 achieves complete remission in a synovial sarcoma model
Abstract Synovial sarcomas are rare tumors arising in adolescents and young adults. The prognosis for advanced disease is ...
MEK Inhibition Suppresses Metastatic Progression of KRAS‐Mutated Gastric Cancer
MEK Inhibition Suppresses Metastatic Progression of KRAS‐Mutated Gastric Cancer
Abstract Metastatic progression of tumors is driven by genetic alterations and tumor-stroma interaction. To elucidate the ...
Mechanism of sensitivity to cisplatin, docetaxel, and 5‐fluorouracil chemoagents and potential erbB2 alternatives in oral cancer with growth differentiation factor 15 overexpression
Mechanism of sensitivity to cisplatin, docetaxel, and 5‐fluorouracil chemoagents and potential erbB2 alternatives in oral cancer with growth differentiation factor 15 overexpression
Abstract The aim of this study was to: (a) explore the potential mechanism of cancer cell sensitivity to cisplatin, doceta...
TSP1 induced PD‐L1‐mediated immunosuppression via activating STAT3 pathway in osteosarcoma
TSP1 induced PD‐L1‐mediated immunosuppression via activating STAT3 pathway in osteosarcoma
Abstract Thrombospondin-1 (TSP1) is generally assumed to suppress the growth of osteosarcoma through inhibiting angiogenes...
NLRP4 negatively regulates type I interferon response and influences the outcome in anti‐PD‐1/PD‐L1 therapy
NLRP4 negatively regulates type I interferon response and influences the outcome in anti‐PD‐1/PD‐L1 therapy
Abstract How to improve the clinical efficacy and enlarge the benefit population of immune checkpoint inhibitors (ICIs) fo...
Paclitaxel‐based supramolecular hydrogel loaded with mifepristone for the inhibition of breast cancer metastasis
Paclitaxel‐based supramolecular hydrogel loaded with mifepristone for the inhibition of breast cancer metastasis
Abstract Breast cancer is the leading cause of cancer death among women and almost all of the breast cancer-caused mortali...
LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
Abstract With the wide clinical use of the third-generation epidermal growth factor receptor (EGFR) inhibitor osimertinib ...
Methyltransferase‐like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1
Methyltransferase‐like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1
Abstract Growing evidence supports that N6-methyladenosine (m6A) modification acts as a critical regulator involved in tum...
Retinol binding protein 1‐dependent activation of NF‐ κB signaling enhances the malignancy of non‐glioblastomatous diffuse gliomas
Retinol binding protein 1‐dependent activation of NF‐ κB signaling enhances the malignancy of non‐glioblastomatous diffuse gliomas
Abstract Nonglioblastomatous diffuse glioma (non-GDG) is a heterogeneous neuroepithelial tumor that exhibits a varied surv...
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