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Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments
Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments
Entheses are specialized tissues that connect ligaments and tendons to the bone surface and are frequently involved in ser...
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis
Neuroblastoma (NB) is a prevalent malignant tumor in children, primarily affecting the nervous system, with a high mortali...
knockdown suppresses the phenotype of house dust mite-induced allergic asthma in mice and cells
knockdown suppresses the phenotype of house dust mite-induced allergic asthma in mice and cells
Allergic asthma is a chronic inflammatory disease of the airways. The objective of this study was to identify potential th...
The role of dendritic cells in recurrent pregnancy loss
The role of dendritic cells in recurrent pregnancy loss
Recurrent pregnancy loss (RPL), defined as ≥ 2 consecutive losses, remains a significant clinical challe...
PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design
PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design
Chronic inflammation underlies many diseases, posing challenges in therapeutic management due to the limitations and side ...
Molecular mechanisms and treatment strategies for discogenic lumbar pain
Molecular mechanisms and treatment strategies for discogenic lumbar pain
Discogenic low back pain (DLBP) is one of the main causes of chronic low back pain, and its core pathological mechanism is...
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC),...
Severe interstitial lung disease as the first manifestation of a variant in a familial case
Severe interstitial lung disease as the first manifestation of a variant in a familial case
STING-associated vasculopathy with onset in infancy (SAVI) is a very rare autosomal-dominant Mendelian autoinflammatory di...
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from complex interactions between genetic, environ...
SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway
SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway
Abnormal galactosylation of IgA is a core factor in the development of IgA nephropathy (IgAN). Suppressor of cytokine sign...
Immunoglobulin G4-related sclerosing mastitis: MRI findings and the literature review
Immunoglobulin G4-related sclerosing mastitis: MRI findings and the literature review
Immunoglobulin G4-related disease (IgG4-RD) is a rare immune-mediated fibro-inflammatory condition that can affect nearly ...
Effects of belimumab on peripheral blood Breg cells and cytokines in childhood systemic lupus erythematosus
Effects of belimumab on peripheral blood Breg cells and cytokines in childhood systemic lupus erythematosus
To evaluate the therapeutic effectiveness of belimumab (BLM) in childhood systemic lupus erythematosus (cSLE) by analyzing...
The role of CD40L-expressing CXCR5CD8 follicular cytotoxic T cells in chronic lymphocytic leukemia
The role of CD40L-expressing CXCR5CD8 follicular cytotoxic T cells in chronic lymphocytic leukemia
A newly identified cell subset within CD8+ T cells expressing CXCR5 of follicular cytotoxic T cells (TFC) lyse th...
GFAP as a marker of astrocytic damage correlated with medication overuse in migraine
GFAP as a marker of astrocytic damage correlated with medication overuse in migraine
Different mechanisms are involved in migraine pathogenesis, including neurogenic inflammation, neurodegenerative processes...
Therapeutic potential of extracellular vesicles in systemic lupus erythematosus: a systematic review
Therapeutic potential of extracellular vesicles in systemic lupus erythematosus: a systematic review
Current therapies for Systemic lupus erythematosus (SLE), such as immunosuppressants and glucocorticoids, are associated w...
Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers
Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers
The field of epigenetics has significantly advanced our understanding of gene regulation in cancer, revealing dynamic modi...
Dissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data
Dissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data
Single-cell transcriptome analysis has made outstanding contributions to the identification of new cell lineages and the s...
Mitochondrial sirtuins 3, 4 and 5 in patients with psoriasis
Mitochondrial sirtuins 3, 4 and 5 in patients with psoriasis
Psoriasis is one of the most common chronic inflammatory skin diseases and is characterised by the uncontrolled proliferat...
Sex-related differences in cell-free DNA and neutrophil extracellular traps in patients with hematologic malignancies
Sex-related differences in cell-free DNA and neutrophil extracellular traps in patients with hematologic malignancies
Cell-free DNA (cfDNA) is emerging as a promising biomarker in liquid biopsy applications for cancer, with growing interest...
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
The inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to re...
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
After stroke, there is a high incidence of acute lung injury and impairment of intestinal barrier function. In this resear...
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
Macrophages, the most abundant cells that participate in tumour progression, are the subject of a number of anticancer the...
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has con...
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
Lung adenocarcinoma (LUAD) is the common form of lung cancer and is prone to distant metastasis. IGF2BP2, an m6A modificat...
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This...
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
Currently, COVID-19 is still striking after 4 years of prevalence, with millions of cases and thousands of fatali...
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
Dendritic cells (DCs) are essential for promoting T lymphocyte responses since they are specialist antigen-presenting cell...
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Helicobacter pylori (Hp) has been postulated as an infectious trigger of psoriatic disease, namely psoriasis (Ps) and psor...
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
This study assessed trends in age-standardized incidence (ASIR), prevalence (ASPR), and mortality rates (ASMR) per 100,000...
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding ...
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