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Investigation of galangin against colorectal cancer through MAPK signaling pathway modulation

As one of the most common cancers in the world, colorectal cancer (CRC) is also a major contributor to cancer-related deat...

International Immunopharmacology

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Targeting TBXAS1: a novel target of daidzein in alleviating APAP-induced hepatic injury

In recent years, the misuse of acetaminophen (APAP), whether accidental or intentional, has led to a significant increase ...

International Immunopharmacology

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Pregnane X receptor activation attenuates intestinal inflammation: The role of pyroptosis and necroptosis inhibition

As an organ in contact with the outside world, the intestines are particularly susceptible to a wide range of external sti...

International Immunopharmacology

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Plumbagin remodels the tumor immune microenvironment to overcome cisplatin resistance in tongue squamous cell carcinoma via KLF2 activation and ZWINT/NF-κB inhibition

Tongue squamous cell carcinoma (TSCC) is an aggressive malignancy with limited therapeutic options and unsatisfactory surv...

International Immunopharmacology

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FOSL1: The core regulatory hub of tumor-neural interactions and its clinical translational prospects

Malignant tumors remain a major global health challenge. The World Health Organization (WHO) reports 19.96 million new cas...

International Immunopharmacology

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Natural products inhibit inflammatory diseases by regulating macrophage polarization

Inflammation serves as a tissue’s defensive mechanism against harmful triggers, helping the body recover from abnormal pat...

International Immunopharmacology

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Cold-inducible RNA-binding protein promotes gut barrier dysfunction and visceral hypersensitivity via activating mast cells in IBS-D

Irritable bowel syndrome (IBS), a chronic functional gastrointestinal disease characterized by abdominal pain accompanying...

International Immunopharmacology

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Neutrophil extracellular traps promote bone loss in type 1 diabetes via suppression of the FN1–PI3K/Akt signaling axis

Fragile fractures are a severe complication of type 1 diabetes mellitus (T1DM), with patients experiencing a 6- to 7-fold ...

International Immunopharmacology

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Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease

Diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) [1]. Current clinical therapies include...

International Immunopharmacology

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Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death

Epilepsy is one of the most prevalent and serious neurological disorders, affecting over 70 million people globally and po...

International Immunopharmacology

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Arsenic trioxide enhances the inhibitory effect of lenvatinib on hepatocellular carcinoma through HMOX1-mediated ferroptosis

Globally, hepatocellular carcinoma (HCC) is the fifth most common neoplasm and the third leading cause of cancer-related m...

International Immunopharmacology

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Phellodendrine alleviates acute pancreatitis by inhibiting p38 MAPK-p47phox pathway-mediated neutrophil extracellular traps formation and ROS production

Acute pancreatitis (AP) represents a predominant cause of hospitalization related to digestive system disorders, marked by...

International Immunopharmacology

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Panobinostat suppresses cGAS-STING pathway activation and ameliorates DSS-induced colitis in mice

Inflammatory bowel disease (IBD) represents a chronic, nonspecific inflammatory condition of the gastrointestinal tract wi...

International Immunopharmacology

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2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide alleviates idiopathic pulmonary fibrosis through activation of LGALS3-mediated AGE-RAGE signaling pathway

Idiopathic pulmonary fibrosis (IPF), representing one of the most aggressive types of pulmonary fibrosis (PF), is characte...

International Immunopharmacology

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Non-lethal sonodynamic therapy-engineered foam cell exosomes reprograms endothelial immunometabolic crosstalk to stabilize atherosclerotic plaques

Cardiovascular diseases (CVDs) remain the primary contributor to global mortality [1]. Atherosclerosis (AS), the most prev...

International Immunopharmacology

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Pathogenesis of osteoarthritis and treatment with traditional Chinese medicine: New perspectives on platelet aggregation

Osteoarthritis (OA) is a common joint disease affecting more than 500 million people worldwide, with a prevalence rate of ...

International Immunopharmacology

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Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation

Postoperative Cognitive Dysfunction (POCD), a condition also encompassed by the broader term ‘Postoperative Neurocognitive...

International Immunopharmacology

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Gut microbiota as a central mediator in hydrogen gas–induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon characterized by persistent mucosal infla...

International Immunopharmacology

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GPRC5A+ myCAFs promote ESCC progression via TGF-β-induced fibroblast activation and ANXA1-mediated M2 macrophage polarization

Esophageal cancer is one of the most aggressive malignancies globally, with a poor clinical prognosis. According to the la...

International Immunopharmacology

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Resolvin E1-Chemerin receptor 1 axis is dysregulated in critical COVID-19 patients

Resolvin E1 (RvE1) and Resolvin D1 (RvD1) are key resolvins implicated in inflammation resolution of respiratory and infec...

International Immunopharmacology

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Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation