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The role of vasculature and angiogenesis in respiratory diseases
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-thre...
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health c...
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (n...
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prem...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to defi...
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
Colorectal cancer (CRC) is one of the common clinical malignancies and the fourth leading cause of cancer-related death in...
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with firs...
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
Nicotine acts as an angiogenic factor by stimulating endogenous cholinergic pathways. Several subtypes of nicotinic acetyl...
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Fine-tuning angiogenesis, the development of new blood vessels, is essential for maintaining a healthy circulatory and lym...
Senescent endothelial cells: a potential target for diabetic retinopathy
Senescent endothelial cells: a potential target for diabetic retinopathy
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Curr...
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
The permeability of blood vessels plays a crucial role in the spread of cancer cells, facilitating their metastasis at dis...
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are kn...
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harm...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
A high-resolution view of the heterogeneous aging endothelium
A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While stud...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Heterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrh...
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
We want to thank Peng et. al for the very thoughtful and important comments on our previous publication. They postulated t...
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomple...
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common mor...
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriove...
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (...
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesize...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Paris Cité University, Innovative Therapies in Hemostasis, INSERM, 75006, Paris, FranceDavid M. Smadja, Aurélien Philippe,...
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogene...
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
The Fig. 3a of this article originally contained an incorrect picture showing “HDAC7/AKAP12 siRNA” condition at t = 0 h. I...
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