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The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in pre...
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
SDF-1α mRNA therapy in peripheral artery disease
SDF-1α mRNA therapy in peripheral artery disease
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases ...
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-...
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and rep...
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system t...
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is ...
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient ou...
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethy...
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequat...
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cau...
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesi...
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when...
Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Wound healing is an essential repair process, and impaired wound healing is a common and sometimes debilitating medical pr...
RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation
RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation
Conflict of interest The authors declare no competing inter...
UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes
UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes
Epigenetics is increasingly recognized as a crucial factor in angiogenesis. Ubiquitin-like with PHD and RING Finger Domain...
MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14
MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14
Critical limb ischemia (CLI) is a refractory peripheral artery disease characterized by tissue ischemia, presenting signif...
Pathophysiology of endothelial dysfunction in Fontan circulation: from bench to bedside and back again
Pathophysiology of endothelial dysfunction in Fontan circulation: from bench to bedside and back again
The Fontan procedure is a definitive surgical approach for complex cardiac malformations, redirecting systemic venous bloo...
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway
Vascular permeability, crucial for organ function, relies on the endothelial barrier formed by intercellular junctions (AJ...
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesi...
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead...
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
COVID-19 is an endothelial disease with two key aspects: endotheliopathy causing coagulopathy and angiogenic disorder, par...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
A novel quantitative angiogenesis assay based on visualized vascular organoid
A novel quantitative angiogenesis assay based on visualized vascular organoid
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease pr...
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