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Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are kn...
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harm...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
A high-resolution view of the heterogeneous aging endothelium
A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While stud...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Heterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrh...
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
We want to thank Peng et. al for the very thoughtful and important comments on our previous publication. They postulated t...
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomple...
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common mor...
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriove...
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (...
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesize...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Paris Cité University, Innovative Therapies in Hemostasis, INSERM, 75006, Paris, FranceDavid M. Smadja, Aurélien Philippe,...
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogene...
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
The Fig. 3a of this article originally contained an incorrect picture showing “HDAC7/AKAP12 siRNA” condition at t = 0 h. I...
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to del...
Targeting the microenvironment in the treatment of arteriovenous malformations
Targeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain,...
Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clu...
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular developm...
2022 14th HHT International Scientific Conference Abstracts
2022 14th HHT International Scientific Conference Abstracts
Medical therapeuticsO1 Cure HHT research network: building the roadmap to cure HHTFriday C, MS1; Krock N1; Schaefer N1; Le...
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Kow CS, Ramachandram DS, Hasan SS (2022) The effect of higher-intensity dosing of anticoagulation on the clinical outcomes...
The modes of angiogenesis: an updated perspective
The modes of angiogenesis: an updated perspective
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a varie...
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
School of Medicine, Klinikum Rechts Der Isar, Department of Nephrology, Technical University of Munich, Ismaninger Str. 22...
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating pot...
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms followi...
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Imatinib, an ABL tyrosine-kinase inhibitor, shows promise in restoring endothelial barrier function in patients with COVID...
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