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Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesi...
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead...
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
COVID-19 is an endothelial disease with two key aspects: endotheliopathy causing coagulopathy and angiogenic disorder, par...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
A novel quantitative angiogenesis assay based on visualized vascular organoid
A novel quantitative angiogenesis assay based on visualized vascular organoid
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease pr...
The role of vasculature and angiogenesis in respiratory diseases
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-thre...
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health c...
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (n...
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prem...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to defi...
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
Colorectal cancer (CRC) is one of the common clinical malignancies and the fourth leading cause of cancer-related death in...
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with firs...
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
Nicotine acts as an angiogenic factor by stimulating endogenous cholinergic pathways. Several subtypes of nicotinic acetyl...
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Fine-tuning angiogenesis, the development of new blood vessels, is essential for maintaining a healthy circulatory and lym...
Senescent endothelial cells: a potential target for diabetic retinopathy
Senescent endothelial cells: a potential target for diabetic retinopathy
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Curr...
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
The permeability of blood vessels plays a crucial role in the spread of cancer cells, facilitating their metastasis at dis...
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are kn...
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harm...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
A high-resolution view of the heterogeneous aging endothelium
A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While stud...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Heterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrh...
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