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Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloi...
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intes...
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2,...
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with l...
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract an...
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are stil...
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorp...
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety co...
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate...
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding...
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocell...
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs ...
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest ...
Animal models of primary biliary cholangitis: status and challenges
Animal models of primary biliary cholangitis: status and challenges
Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenes...
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Gene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a l...
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attent...
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regula...
The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effecti...
Coffee as a dietary strategy to prevent SARS-CoV-2 infection
Coffee as a dietary strategy to prevent SARS-CoV-2 infection
To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preve...
Clinical biomarkers for Lewy body diseases
Clinical biomarkers for Lewy body diseases
Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial &#...
METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells
METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells
Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dy...
Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study
Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study
Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal r...
Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition
Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition
Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metast...
Correction: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells
Correction: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-popula...
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflamma...
ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells
ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells
In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ...
Niclosamide improves cancer immunotherapy by modulating RNA-binding protein HuR-mediated PD-L1 signaling
Niclosamide improves cancer immunotherapy by modulating RNA-binding protein HuR-mediated PD-L1 signaling
Immune checkpoint blockade (ICB) represents a revolutionary advance in cancer treatment but remains limited success in tri...
c-Jun as a one-way valve at the naive to primed interface
c-Jun as a one-way valve at the naive to primed interface
c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and p...
Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep
Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep
It is not uncommon for some individuals to retain certain primitive characteristics even after domestication or long-term ...
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