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The influence of SARS-CoV-2 spike protein exposure on retinal development in the human retinal organoids
The influence of SARS-CoV-2 spike protein exposure on retinal development in the human retinal organoids
Pregnant women are considered a high-risk population for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)&...
Special correlation between diet and MASLD: positive or negative?
Special correlation between diet and MASLD: positive or negative?
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic and systemic metabolic liver disease charact...
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8
Acute megakaryoblastic leukemia (AMKL) is a rare hematological malignancy in adults but children. Alternative splicing (AS...
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease
The identification and intervention of Alzheimer’s Disease (AD) in its early-stage allows for the timely implementat...
Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes
Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes
In recent years, advancements in metagenomics, metabolomics, and single-cell sequencing have enhanced our understanding of...
Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
Neural stem cells (NSCs) play a crucial role in the progress of ischemic stroke. Research on zebrafish embryonic demonstra...
Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes
Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes
Occludin, a crucial component of tight junctions, has emerged as a promising biomarker for the diagnosis of acute ischemic...
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma
Lung cancer, a leading global cause of cancer-related mortality, necessitates enhanced prognostic markers for improved tre...
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice
In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells w...
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis
Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a ...
Distinct signatures of gut microbiota and metabolites in primary biliary cholangitis with poor biochemical response after ursodeoxycholic acid treatment
Distinct signatures of gut microbiota and metabolites in primary biliary cholangitis with poor biochemical response after ursodeoxycholic acid treatment
About 1/3 of primary biliary cholangitis (PBC) patients suffered from poor response worldwide. And these patients present ...
Rapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Rapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological proce...
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
Neural progenitor cells (NPCs) can be cultivated from developing brains, reproducing many of the processes that occur duri...
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as ...
Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease
Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease
Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and pathology. In particular, PA have be...
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloi...
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intes...
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2,...
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with l...
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract an...
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are stil...
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorp...
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State
The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety co...
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate...
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology
Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding...
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocell...
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs ...
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest ...
Animal models of primary biliary cholangitis: status and challenges
Animal models of primary biliary cholangitis: status and challenges
Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenes...
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Gene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a l...
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