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Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023
Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023
The Advances in Targeted Therapies meets annually, convening experts in the field of rheumatology to both provide scientif...
Third-generation CD19.CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis
Third-generation CD19.CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis
No effective treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD) exists. Numerous evidences sup...
CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion
CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion
IntroductionSystemic sclerosis (SSc) is a systemic autoimmune disease that is characterised by vasculopathy, inflammation ...
Low plasma belimumab levels as an indicator of poor adherence to belimumab in patients with systemic lupus erythematosus
Low plasma belimumab levels as an indicator of poor adherence to belimumab in patients with systemic lupus erythematosus
Non-adherence is a significant issue in the treatment of systemic lupus erythematosus (SLE), associated with the risks of ...
Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot study)
Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot study)
IntroductionRheumatoid arthritis (RA) is a chronic autoimmune disorder that causes inflammation in the joints, leading to ...
Lower body mass and lower adiposity are associated with differential responses to two treatment strategies for rheumatoid arthritis
Lower body mass and lower adiposity are associated with differential responses to two treatment strategies for rheumatoid arthritis
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Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial
Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial
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Male patients with inflammatory joint diseases are less likely than controls to be childless: results from a Norwegian population-based cohort study of 10 865 patients
Male patients with inflammatory joint diseases are less likely than controls to be childless: results from a Norwegian population-based cohort study of 10 865 patients
WHAT IS ALREADY KNOWN ON THIS TOPICThere are limited data regarding fertility in male patients with inflammatory joint dis...
Mortality in patients with psoriatic arthritis in Sweden: a nationwide, population-based cohort study
Mortality in patients with psoriatic arthritis in Sweden: a nationwide, population-based cohort study
Main findingsIn this large, nationwide, population-based, 12-year, cohort study (PsA cases, n=33 026), the all-cause morta...
Telitacicept in patients with active systemic lupus erythematosus: results of a phase 2b, randomised, double-blind, placebo-controlled trial
Telitacicept in patients with active systemic lupus erythematosus: results of a phase 2b, randomised, double-blind, placebo-controlled trial
IntroductionSystemic lupus erythematosus (SLE) is a heterogeneous and biologically complex autoimmune disease that can lea...
Pragmatic targets for moderate/severe SLE and their implications for clinical care and trial design: sustained DORIS or LLDAS for at least 6 months is sufficient while their attainment for at least 24 months ensures high specificity for damage-free progression
Pragmatic targets for moderate/severe SLE and their implications for clinical care and trial design: sustained DORIS or LLDAS for at least 6 months is sufficient while their attainment for at least 24 months ensures high specificity for damage-free progression
IntroductionThe treat-to-target paradigm has been successfully applied to many chronic conditions, including inflammatory ...
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionAnti-neutrophil cyt...
Morris Ziff
Morris Ziff
We, rheumatologists, practise in an era when the study of rheumatic diseases and the care of affected patients are rooted ...
Bona fide dendritic cells are pivotal precursors for osteoclasts
Bona fide dendritic cells are pivotal precursors for osteoclasts
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Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasus arteritis, ANCA-associated vasculitis and giant cell arteritis
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasus arteritis, ANCA-associated vasculitis and giant cell arteritis
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IgG4-related tubulointerstitial nephritis
IgG4-related tubulointerstitial nephritis
A 73-year-old man with previous cerebral infarction, diabetes mellitus and IgG4-related disease had received rituximab tre...
Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Pagets disease of bone
Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Pagets disease of bone
WHAT IS ALREADY KNOWN ON THIS TOPICPaget’s disease of bone (PDB) frequently presents at an advanced stage with complicatio...
Subclinical inflammation and joint damage progression in patients with early RA fulfilling 2011 vs 2022 ACR/EULAR Boolean remission criteria: data from the ARCTIC study
Subclinical inflammation and joint damage progression in patients with early RA fulfilling 2011 vs 2022 ACR/EULAR Boolean remission criteria: data from the ARCTIC study
Remission has become an achievable goal for a large proportion of patients with rheumatoid arthritis (RA).1 In 2022, ACR a...
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
IntroductionEvidence from basic research and clinical trials demonstrates that the interleukin (IL) 17 immune axis exerts ...
Annals of the Rheumatic Diseases collection on autoantibodies in the rheumatic diseases: new insights into pathogenesis and the development of novel biomarkers
Annals of the Rheumatic Diseases collection on autoantibodies in the rheumatic diseases: new insights into pathogenesis and the development of novel biomarkers
IntroductionAutoimmunity is central to the pathogenesis of many rheumatic diseases and has therefore been the focus of man...
The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
IntroductionCalcium pyrophosphate deposition (CPPD) disease is a common symptomatic arthritis characterised by the deposit...
2023 ACR/EULAR antiphospholipid syndrome classification criteria
2023 ACR/EULAR antiphospholipid syndrome classification criteria
IntroductionAntiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by arterial, venous, or microva...
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine
Mathian et al described the clinical course and heterogeneity of COVID-19 in 17 systemic lupus erythematosus (SLE) patient...
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSFor the first time, three biologics with different modes of action,...
Three-month tapering and discontinuation of long- term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial
Three-month tapering and discontinuation of long- term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial
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Cost-utility analysis of tapering strategies of biologicals in rheumatoid arthritis patients in the Netherlands
Cost-utility analysis of tapering strategies of biologicals in rheumatoid arthritis patients in the Netherlands
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SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy
SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy
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Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
ResultsGut dysbiosis is pronounced in patients with high disease activityTo study the gut microbial communities in sequent...
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
AbstractObjectives The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral b...
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020
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