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Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: a comprehensive meta‐analysis based on a Cochrane Systematic Review
Abstract Codeletion of chromosomal arms 1p and 19q, in conjunction with a mutation in the isocitrate dehydrogenase 1 or 2 ...
Neuropathology And Applied Neurobiology
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The Blood‐CSF‐Brain Route of Neurological Disease: The Indirect Pathway into the Brain.
Abstract The brain is protected by the endothelial blood-brain-barrier (BBB) that limits the access of micro-organisms, tu...
Neuropathology And Applied Neurobiology
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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice
Abstract Aims Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise an...
Neuropathology And Applied Neurobiology
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Old age genetically confirmed frontotemporal lobar degeneration with TDP‐43 has limbic predominant TDP‐43 deposition
Abstract Aims To assess the burden of transactive response DNA-binding protein of 43 kDa (TDP-43) inclusions in a uni...
Neuropathology And Applied Neurobiology
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Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis
Abstract Aims To determine the underlying cellular changes and clinical correlates associated with pathology of the hypoth...
Neuropathology And Applied Neurobiology
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Primary Age‐Related Tauopathy (PART) in a Finnish Population‐Based Study of the Oldest Old (Vantaa 85+)
Abstract Aims Few studies have investigated primary age-related tauopathy (PART) in a population-based setting. Here we as...
Neuropathology And Applied Neurobiology
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Intranuclear inclusions in skin biopsies are not limited to neuronal intranuclear inclusion disease but can also be seen in oculopharyngodistal myopathy
Key Points We investigated the presence of intranuclear inclusions in skin biopsies from patients with oculopharyngodistal...
Neuropathology And Applied Neurobiology
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Brain TDP‐43 pathology in corticobasal degeneration: topographical correlation with neuronal loss
Abstract Aims Neuronal and glial inclusions comprising transactive response DNA-binding protein of 43 kDa (TDP-43) have be...
Neuropathology And Applied Neurobiology
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Long‐standing multiple system atrophy‐Parkinsonism with limbic and FTLD‐type α‐synuclein pathology
Corresponding Author Department of Pathology, University of California San Dieg...
Neuropathology And Applied Neurobiology
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Correlations in post‐mortem imaging‐histopathology studies of sporadic human cerebral small vessel disease: A systematic review
Abstract Aims Sporadic human cerebral small vessel disease (SVD) commonly causes stroke and dementia but its pathogenesis ...
Neuropathology And Applied Neurobiology
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Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo
Abstract Aim The heterogeneity in the distribution and morphological features of TAR DNA-binding protein-43 (TDP-43) patho...
Neuropathology And Applied Neurobiology
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TDP‐43 proteinopathy occurs independently of autophagic substrate accumulation and underlies nuclear defects in Niemann‐Pick C disease
Abstract Aims Neuronal cytoplasmic inclusions of TAR-DNA binding protein of 43 kDa (TDP-43) are a pathological hallma...
Neuropathology And Applied Neurobiology
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Machine learning‐based decision tree classifier for the diagnosis of progressive supranuclear palsy and corticobasal degeneration
Abstract Aims This study aimed to clarify the different topographical distribution of tau pathology between progressive su...
Neuropathology And Applied Neurobiology
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Atypical astroglial pTDP‐43 pathology in astroglial predominant tauopathy
We observed atypical astrocytic pTDP-43 pathology in astroglial predominant tauopathy.
Neuropathology And Applied Neurobiology
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Spatial molecular profiling of a central nervous system low‐grade diffusely infiltrative tumour with INI1 deficiency featuring a high‐grade atypical teratoid/rhabdoid tumour component
We performed spatial epigenetic and transcriptomic analyses of a highly unusual low-grade diffusely infiltrative tumour wi...
Neuropathology And Applied Neurobiology
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Longstanding Multiple System Atrophy‐Parkinsonism with Limbic and FTLD‐type α‐Synuclein Pathology
Abstract Multiple system atrophy (MSA) is a sporadic neurodegenerative disease clinically marked by autonomic failure and ...
Neuropathology And Applied Neurobiology
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Automated immunofluorescence analysis for sensitive and precise dystrophin quantification in muscle biopsies
Abstract Aims Dystrophin, the protein product of the DMD gene, plays a critical role in muscle integrity by stabilizing th...
Neuropathology And Applied Neurobiology
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The desmin mutation R349P increases contractility and fragility of stem cell‐generated muscle micro‐tissues
Abstract Aims Desminopathies comprise hereditary myopathies and cardiomyopathies caused by mutations in the intermediate f...
Neuropathology And Applied Neurobiology
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AKT1E17K‐mutated meningioma cell lines respond to treatment with the AKT inhibitor AZD5363
Abstract Objectives Meningiomas are the most frequent primary brain tumours. Recently, knowledge about the molecular drive...
Neuropathology And Applied Neurobiology
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Dysfunction of the blood‐brain barrier in Alzheimer’s disease: evidence from human studies
Abstract The pathological processes leading to synapse loss, neuronal loss, brain atrophy and gliosis in Alzheimer´s ...
Neuropathology And Applied Neurobiology
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Concurrent tau pathologies in frontotemporal lobar degeneration with TDP‐43 pathology
Abstract Aims Accumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have patholog...
Neuropathology And Applied Neurobiology
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Neuropathology of a patient with Alzheimer disease treated with low doses of Verubecestat
nan12781-sup-0001-Supplementary Information.docxWord 2007 document , 7.7 MB ...
Neuropathology And Applied Neurobiology
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Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation
Abstract Aims To illuminate the pathological synergy between Aβ and tau leading to the neurofibrillary tangles (NFT)...
Neuropathology And Applied Neurobiology
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Alpha adaptins show isoform‐specific association with neurofibrillary tangles in Alzheimer’s disease.
Abstract Aims The heterotetrameric assembly protein complex 2 (AP-2) is a central hub for clathrin-dependent endocytosis. ...
Neuropathology And Applied Neurobiology
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Non‐coding regulatory elements: potential roles in disease and the case of epilepsy
Abstract Non-coding DNA (ncDNA) refers to the portion of the genome that does not code for proteins and accounts for the g...
Neuropathology And Applied Neurobiology
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Spatial molecular profiling of a central nervous system low‐grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT‐INI1) featuring a high‐grade AT/RT component
Corresponding Author Center for Molecular Neurobiology (ZMNH), University Medic...
Neuropathology And Applied Neurobiology
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Neurotherapeutic implications of sense and respond strategies generated by astrocytes and astrocytic tumours to combat pH mechanical stress
Abstract Aims Astrocytes adapt to acute acid stress. Intriguingly, cancer cells with astrocytic differentiation thrive eve...
Neuropathology And Applied Neurobiology
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Interfering with lysophosphatidic acid receptor edg2/lpa1 signalling slows down disease progression in SOD1‐G93A transgenic mice
Abstract Aims Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, d...
Neuropathology And Applied Neurobiology
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Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma
Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital ...
Neuropathology And Applied Neurobiology
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TUMOUR‐ASSOCIATED CD204+ MICROGLIA/MACROPHAGES ACCUMULATE IN PERIVASCULAR AND PERINECROTIC NICHES AND CORRELATE WITH AN INTERLEUKIN‐6 ENRICHED INFLAMMATORY PROFILE IN GLIOBLASTOMA
Abstract Aims Glioblastomas are heterogeneous tumours with a rich tumour microenvironment particularly comprised of tumour...
Neuropathology And Applied Neurobiology
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