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KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the in...
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such...
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
Although GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in...
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Vascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (...
Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transfe...
Applications of lung cancer organoids in precision medicine: from bench to bedside
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwid...
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mec...
New insights into the stemness of adoptively transferred T cells by γc family cytokines
New insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthr...
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
This study aimed to identify an orcl1 mutation in a patient with Dent-2 Disease and investigate the underlying mechanisms....
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regul...
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require...
Natural killer cells in the central nervous system
Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effector...
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cy...
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various ...
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a...
Targeting ferroptosis in melanoma: cancer therapeutics
Targeting ferroptosis in melanoma: cancer therapeutics
Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for ...
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Foetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communic...
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 rece...
New insights into the regulation of METTL3 and its role in tumors
New insights into the regulation of METTL3 and its role in tumors
As one of the most abundant epigenetic modifications in RNA, N6-methyladenosine (m6A) affects RNA transcription, splicing,...
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is com...
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Although interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been i...
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
Inflammation plays a significant role in various cancers, including lung cancer, where the inflammatory cytokine IL-1β...
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoi...
PKCδ regulates the vascular biology in diabetic atherosclerosis
PKCδ regulates the vascular biology in diabetic atherosclerosis
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social p...
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent n...
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin is a type of statins with anti-cancer...
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling cascades and molecular mechani...
Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior
Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior
The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significan...
Unveiling the potential effects of acetylsalicylic acid: insights into regeneration in endometrial stem cells
Unveiling the potential effects of acetylsalicylic acid: insights into regeneration in endometrial stem cells
Although acetylsalicylic acid has been widely used for decades to treat and prevent various diseases, its potential effect...
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