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A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia
A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia
About 40% of relapsed or non-responder tumors exhibit therapeutic resistance in the absence of a clear genetic cause, sugg...
NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance
NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance
The development of morphine tolerance presents a major clinical challenge in the effective management of severe pain. This...
Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response
Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response
Local interstitial acidosis in chronic kidney disease (CKD) induces inflammatory responses and dedifferentiation of proxim...
Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury
Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury
Enterovirus 71 (EV71) is a major etiologic pathogen for hand-foot-and-mouth disease (HFMD) in young children. Severe cases...
Hematopoietic stem cell state and fate in trained immunity
Hematopoietic stem cell state and fate in trained immunity
Trained immunity serves as a de facto memory for innate immune responses, resulting in long-term functional reprogramming ...
Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism
Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism
The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represe...
Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1+PD1+CD8+ T cell differentiation
Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1+PD1+CD8+ T cell differentiation
Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, som...
Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases
Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases
Protein kinases are critical components of a myriad biological processes and strongly associated with various diseases. Wh...
Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection
Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection
Ubiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses an...
Alternative splicing in ovarian cancer
Alternative splicing in ovarian cancer
Ovarian cancer is the second leading cause of gynecologic cancer death worldwide, with only 20% of cases detected early du...
Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by over...
Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils
Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils
Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause sight threatening infections in the eye and fatal ...
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breas...
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the in...
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such...
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
Although GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in...
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Vascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (...
Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transfe...
Applications of lung cancer organoids in precision medicine: from bench to bedside
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwid...
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mec...
New insights into the stemness of adoptively transferred T cells by γc family cytokines
New insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthr...
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
This study aimed to identify an orcl1 mutation in a patient with Dent-2 Disease and investigate the underlying mechanisms....
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regul...
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require...
Natural killer cells in the central nervous system
Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effector...
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cy...
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various ...
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a...
Targeting ferroptosis in melanoma: cancer therapeutics
Targeting ferroptosis in melanoma: cancer therapeutics
Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for ...
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