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Brain Age of Rhesus Macaques over the Lifespan
Brain Age of Rhesus Macaques over the Lifespan
Available online 9 March 2024Author links open overlay panel, , , , , , , , , , Highlights•Machine-learning based rhesus m...
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression
Alzheimer’s disease (AD) is a neurodegenerative disorder with a dual proteinopathy as key markers of its pathology: accumu...
Brain oscillatory processes related to sequence memory in healthy older adults
Brain oscillatory processes related to sequence memory in healthy older adults
Sequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed ...
The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank
The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank
All data analyzed herein (including IDPs) were provided by UK Biobank under project reference 68400, subject to a data tra...
Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology
Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology
Psychosis in Alzheimer’s Disease (AD) is defined as the presence of delusions, i.e. fixed false beliefs, or visual or audi...
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Alzheimer Disease (AD) is prevalent in 5.8 million Americans over the age of 65, characterized by progressive cognitive de...
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Past research has suggested greater levels of cognitive engagement have benefits for neurocognitive function across the li...
Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques
Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques
Scalp-based, noninvasive modalities such as electroencephalography (EEG), magnetoencephalography (MEG), transcranial elect...
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomato...
Cytokine profiling in senescent and reactive astrocytes: A systematic review
Cytokine profiling in senescent and reactive astrocytes: A systematic review
In recent years, neuroinflammation has been accepted as one of the most important factors leading to age-associated cognit...
APOE-ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
APOE-ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
Volume 138, June 2024, Pages 72-82Author links open overlay panel, , , , , , , , AbstractIntroductionHearing loss and dimi...
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults
Ann D. Cohen: Writing – review & editing, Supervision, Resources, Project administration, Methodology, Investigation, ...
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice
Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disease characterized by memory loss and cognit...
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Exploring the neural basis of age-related decline in working memory is vital in our aging society. Previous electroencepha...
Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline
Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline
Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this f...
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer’s disease
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer’s disease
Volume 139, July 2024, Pages 1-4Author links open overlay panel, , , , , , , Highlights•Relative gamma power is higher in ...
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (W...
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work a...
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
Among older people, age-related hearing loss is the most common sensory disturbance and is characterized by progressive lo...
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Chronic low-grade inflammation (or “inflammaging”) is a common hallmark of ageing and is associated with diabetes, obesity...
Prevalence of cerebral microbleeds in Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease dementia: a systematic review and meta-analysis
Prevalence of cerebral microbleeds in Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease dementia: a systematic review and meta-analysis
Cerebral microbleeds (CMB) are small, round, focal haemorrhages visible on T2*-weighted gradient-recalled echo (GRE) or su...
Rare variant analysis of UQCRC1 in Chinese patients with early-onset Parkinson’s disease
Rare variant analysis of UQCRC1 in Chinese patients with early-onset Parkinson’s disease
Although the exact cause of Parkinson’s disease (PD) remains unknown, genetic and environmental factors have been found to...
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra
The selective loss of substantia nigra (SN) dopaminergic (DA) neurons in neurodegenerative disorders including Parkinson’s...
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis
Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further,...
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive decline of cognitive function from th...
Identifying risk loci for FTD and shared genetic component with ALS: a large-scale multi-trait association analysis
Identifying risk loci for FTD and shared genetic component with ALS: a large-scale multi-trait association analysis
Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further,...
Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42
Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42
Although genome-wide association studies (GWAS) have identified multiple Alzheimer's disease (AD)-associated loci by selec...
FRONTOPARIETAL FUNCTION AND UNDERLYING STRUCTURE REFLECT CAPACITY FOR MOTOR SKILL ACQUISITION DURING HEALTHY AGING
FRONTOPARIETAL FUNCTION AND UNDERLYING STRUCTURE REFLECT CAPACITY FOR MOTOR SKILL ACQUISITION DURING HEALTHY AGING
SK: data curation, formal analysis, visualization, writing – original draft, writing – review & editing. CR: investiga...
Dopamine Transporter Positron Emission Tomography in Patients with Alzheimer’s Disease with Lewy Body Disease Features
Dopamine Transporter Positron Emission Tomography in Patients with Alzheimer’s Disease with Lewy Body Disease Features
Alzheimer’s disease (AD) (McKhann et al., 2011), the most common neurodegenerative cause of dementia, is characterized by ...
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: a longitudinal study
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: a longitudinal study
Available online 8 November 2023Author links open overlay panel, , , , , , , , , , , Highlights•In both CN and MCI patient...
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