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A comprehensive in silico analysis of mutation spectrum of maple syrup urine disease (MSUD) genes in Iranian population
Maple syrup urine disease (MSUD) represents an infrequent metabolic disease precipitated by an insufficiency of the enzyma...
In silico analysis for SARS-CoV-2 detection in the context of genetic variability of the Algerian omicron variant
The risk to public health conferred by the Omicron variant is still not completely clear, although its numerous gene mutat...
Comparison of inflammatory molecular mechanisms between osteoarthritis and rheumatoid arthritis via gene microarrays
Osteoarthritis (OA) and rheumatoid arthritis (RA) treatment requires exact arthritis type diagnosis. We compared inflammat...
Down-regulation of key regulatory factors in sphingosine-1-phosphate (S1P) pathway in human lung fibroblasts transfected with selected microRNAs
Sphingosine 1 phosphate (S1P) is involved in the pathogenesis of asthma by stimulation of the alpha-smooth muscle actin (S...
The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat
Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective prope...
In-silico comparison of fungal and bacterial asparaginase enzymes
L-asparaginase is a commercial enzyme with a wide variety of applications. Asparaginase is known as an anti-cancer agent t...
Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and ra...
The effects of NLRP3 rs10754558 and rs4612666 polymorphisms on preeclampsia susceptibility, onset, and severity: a case-control study and in silico analysis
Preeclampsia (PE) is one of the serious complications of pregnancy and its exact etiology is unknown. Inflammasomes are mu...
Genome-wide mining and characterization of MATE transporters in Coriandrum sativum L.
Multidrug and Toxic Compound Extrusion (MATE) proteins are responsible for the transport of a wide range of metabolites ou...
Comparison of Mir122 expression in children with biliary atresia and healthy group
Biliary atresia (BA) is the primary cause of neonatal jaundice with various pathological mechanisms. Many BA patients may ...
Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients
Silymarin is known for its anti-inflammatory and antioxidant properties. We investigated these effects on serum levels of ...
Natural compounds solasonine and alisol B23-acetate target GLI3 signaling to block oncogenesis in MED12-altered breast cancer
Breast cancer remains to be the second leading cause of cancer deaths worldwide thereby highlighting the critical need to ...
A survey of resistance mutations to reverse transcriptase inhibitors (RTIs) among HIV-1 patients in northeast of Iran
The use of a combination of three-drug regimen has improved HIV-1 infected patients' life span and quality; however t...
Valproic acid and/or rapamycin preconditioning protects hair follicle stem cells from oxygen glucose serum deprivation-induced oxidative injury via activating Nrf2 pathway
Among leading causes of the ischemic stroke pathogenesis, oxidative stress strongly declines rate of stem cell engraftment...
The effects of thymidylate synthase 3'UTR genotype on methylation of tumor-specific genes promoter in 22 colorectal cancer patients from southern Iran
To investigate the effects of thymidylate synthase (TS) 3'UTR genotype on promotor methylation of tumor-related genes...
Examining the expression of low-density lipoprotein receptor (LDLR) and low-density lipoprotein receptor-related protein 6 (LRP6) genes in breast cancer cell lines
Cholesterol and the Wnt/β-catenin pathway have an effective role in the proliferation, survival, drug resistance,...
The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells
Breast cancer is particularly severe in women. Research highlights the crucial role of miRNAs in key cellular processes, s...
Association study of the polymorphisms rs2228611 of the DNMT1 gene and rs1569686 of the DNMT3B gene with bladder cancer development in a sample of the Algerian population
Bladder cancer (BC) is a multifactorial disease with a poorly understood main cause. In this study, we aimed to evaluate t...
Phylogenetic position inferred on SSU rDNA sequence gene and description of a new parasitic cnidarian (Endocnidozoa: Myxobolidae) infecting Markiana nigripinnis (Teleostei: Stevardiinae) from a small marginal lake floodplain, Brazil
Herein, a detailed molecular phylogeny analysis was developed to determine the phylogenetic position of a new freshwater h...
Hijacking the epigenetic mechanisms of A. baumannii
Epigenetic mechanisms attribute to the resistance and virulence of Acinetobacter baumannii sparking a renewed area of rese...
Allele and genotype frequencies of β-lactoglobulin gene using PCR-RFLP in Algerian local cattle populations
Milk protein genetic polymorphisms are associated with economically important traits in dairy cattle. The objective of thi...
In-silico structural analysis of Heterocephalus glaber amyloid beta: an anti-Alzheimer's peptide
Heterocephalus glaber, known as the Naked mole-rat, has an extraordinary immunity to Alzheimer's disease. The patholo...
MicroRNAs targeting CDKN2A gene as a potential prognostic marker in head and neck squamous cell carcinoma
Epigenetic factors are known to markedly influence the functions of a gene by modification of transcripts, via methylation...
Evaluation of Beclin1 and mTOR genes and p62 protein expression in breast tumor tissues of Iranian patients
Autophagy is a cellular process that plays a major role in the fate of tumor cells. Understanding the role of autophagy in...
Arginine to glutamine mutation in the substrate binding region impaired the isopentenyl activity of Mycobacterium tuberculosis MiaA
tRNAs act as adaptors during protein synthesis and are chemically modified post-transcriptionally for their structural sta...
The importance of examining the Hardy-Weinberg Equilibrium in genetic association studies
No abstract
A comparison of phylogenetic and distance-based approaches for the distinction of genetically closed species, Draba rimarum (Rech.f.) A.R. Khosravi & A. Eslami-Farouji, and Draba aucheri Boiss. (Brassicaceae) as a case study
Circumscribing species boundries is necessary in systematic plant biology. Even a mistake in delimiting taxa may lead to i...
Human BKV large T genome detection in prostate cancer and benign prostatic hyperplasia tissue samples by nested PCR: A case-control study
Human BK polyomavirus (BKPyV) is a latent infectious agent in the genitourinary tract associated with hemorrhagic cystitis...
Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (...
Genetic association between rs1695 in glutathione S-transferase P1 and risk of periodontitis: a pilot study
The present study aims to determine the association between a genetic polymorphism of GSTP1 (rs1695) and the risk of perio...
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