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Prevalence of primary aldosteronism in acute stroke or transient ischemic attack: a systematic review and meta-analysis
Prevalence of primary aldosteronism in acute stroke or transient ischemic attack: a systematic review and meta-analysis
<sec><title>Background and purpose</title><p>Primary aldosteronism (PA) is the most common endocri...
Oral health’s role in diabetes risk: a cross-sectional study with sociodemographic and lifestyle insights
Oral health’s role in diabetes risk: a cross-sectional study with sociodemographic and lifestyle insights
<sec><title>Introduction</title><p>Diabetes, a key chronic non-communicable disease, poses a subst...
Central hyperthyroidism due to an ectopic TSH-secreting pituitary tumor: a case report and literature review
Central hyperthyroidism due to an ectopic TSH-secreting pituitary tumor: a case report and literature review
<p>Ectopic thyroid-stimulating hormone (TSH)-secreting tumors are extremely rare, with only 15 reported cases in the...
ERCC4: a potential regulatory factor in inflammatory bowel disease and inflammation-associated colorectal cancer
ERCC4: a potential regulatory factor in inflammatory bowel disease and inflammation-associated colorectal cancer
<p>The pathogenesis of inflammatory bowel disease (IBD) remains unclear and is associated with an increased risk of ...
Associations of weight-adjusted-waist index and depression with secondary infertility
Associations of weight-adjusted-waist index and depression with secondary infertility
<sec><title>Background</title><p>Obesity and psychological factors were identified as risk factors...
Thyroid hormone action in adult neurogliogenic niches: the known and unknown
Thyroid hormone action in adult neurogliogenic niches: the known and unknown
<p>Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the prope...
Ovarian tissue transplantation: 10 years of experience at the Bologna University
Ovarian tissue transplantation: 10 years of experience at the Bologna University
<sec><title>Objective</title><p>The efficiency of ovarian tissue transplantation (OTT) was establi...
Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors
Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors
<sec><title>Background</title><p>Owing to individual heterogeneity, patients with idiopathic membr...
Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis
Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis
<p>The leading indicator for successful outcomes in <italic>in-vitro</italic> fertilization (IVF) is the...
Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study
Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study
<sec><title>Background and objectives</title><p>Hashimoto’s thyroiditis (HT), a chronic autoimmune...
Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
<sec><title>Background</title><p>CXC chemokine receptor 4 (CXCR4) is associated with the progressi...
Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016
Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016
<sec><title>Background</title><p>Obesity and metabolic syndrome pose significant health challenges...
Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study
Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study
<sec><title>Introduction</title><p>Global phase III clinical trials have shown superior hypoglycem...
Vericiguat in patients with heart failure across the spectrum of left ventricular ejection fraction: a patient-level, pooled meta-analysis of VITALITY-HFpEF and VICTORIA
Vericiguat in patients with heart failure across the spectrum of left ventricular ejection fraction: a patient-level, pooled meta-analysis of VITALITY-HFpEF and VICTORIA
<p>Vericiguat, the newest soluble guanylate cyclase (sGC) drug, is potentially beneficial in treating heart failure ...
Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study
Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study
<p>Maturity-onset diabetes of the young (MODY) is a grouping of monogenic disorders. It is characterized by dominant...
Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe
Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe
<p>Over the last years non-alcoholic fatty liver disease (NAFLD) has grown into the most common chronic liver diseas...
Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults
Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults
<sec><title>Purpose</title><p>This study aims to compare the association of hypertension plus hype...
Association of the metabolic score for insulin resistance with cardiovascular diseases, cardiovascular and all-cause mortality in Chinese hypertensive population
Association of the metabolic score for insulin resistance with cardiovascular diseases, cardiovascular and all-cause mortality in Chinese hypertensive population
<sec><title>Importance</title><p>Little is known about the relationship between the metabolic scor...
Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis
Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis
<sec><title>Aim</title><p>The retinal and choroidal parameters were analyzed to understand the imp...
Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia
Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia
<sec><title>Objective</title><p>To improve the accuracy of preimplantation genetic testing (PGT) i...
Thyroid hormone levels and BMI-SDS changes in adolescents with obesity
Thyroid hormone levels and BMI-SDS changes in adolescents with obesity
BackgroundThyroid hormones play an important role in energy metabolism and weight control, explained mostly by inducing th...
Comparing pyrotinib with trastuzumab and pertuzumab with trastuzumab for HER2-positive metastatic breast cancer: a retrospective, multicenter analysis
Comparing pyrotinib with trastuzumab and pertuzumab with trastuzumab for HER2-positive metastatic breast cancer: a retrospective, multicenter analysis
ObjectivePyrotinib and pertuzumab are effective treatment options for HER2-positive metastatic breast cancer (HER2+ MBC). ...
Single-cell RNA-seq identified novel genes involved in primordial follicle formation
Single-cell RNA-seq identified novel genes involved in primordial follicle formation
IntroductionThe number of primordial follicles (PFs) in mammals determines the ovarian reserve, and impairment of primordi...
Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis
Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis
Obesity is a pathophysiological condition, dependent on body fat accumulation, that progressively induces systemic oxidati...
Protective role of perivascular adipose tissue in the cardiovascular system
Protective role of perivascular adipose tissue in the cardiovascular system
This review provides an overview of the key role played by perivascular adipose tissue (PVAT) in the protection of cardiov...
Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish
Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish
In zebrafish, estrogens produced in the ovaries via Cyp19a1a activity are required for both sexual differentiation of the ...
Association of trajectory of body shape index with all-cause and cause-specific mortality: 18 years follow-up
Association of trajectory of body shape index with all-cause and cause-specific mortality: 18 years follow-up
ObjectivesThe current study aimed to examine how the trajectory of a body shape index (ABSI) could predict mortality in a ...
Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver
Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver
Preclinical and clinical studies suggest that hypothyroidism might cause hepatic endocrine and metabolic disturbances with...
Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis
Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis
IntroductionEndometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ecto...
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and machine learning
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and machine learning
BackgroundThyroid carcinoma (THCA), the most common endocrine neoplasm, typically exhibits an indolent behavior. However, ...
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