SCI Abstract

search
+
KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis
KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis
Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent insights into ferroptosis have opened new avenue...
Microglial activation is inhibited by selective anti-seizure medications
Microglial activation is inhibited by selective anti-seizure medications
To investigate the anti-inflammatory properties of anti-seizure medications (ASMs) administered to patients with drug-resi...
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming
Pulmonary inflammation is closely associated with macrophage polarization and lipid metabolic reprogramming. Miconazole (M...
Advances in fibroblast-based cardiac reprogramming in the treatment of heart disease
Advances in fibroblast-based cardiac reprogramming in the treatment of heart disease
Due to population aging and a wide range of risk factors, coupled with the limited regenerative capacity of the myocardium...
Impact of sepsis on bone marrow mesenchymal stem cells and its implications for hematopoiesis and immunosuppression
Impact of sepsis on bone marrow mesenchymal stem cells and its implications for hematopoiesis and immunosuppression
Septic patients often exhibit disruption of the normal hematopoiesis, leading to hematological abnormalities such as anaem...
A systematic review of novel Phosphodiesterase-4 inhibitors in the treatment of psoriasis
A systematic review of novel Phosphodiesterase-4 inhibitors in the treatment of psoriasis
Psoriasis is a chronic immune-mediated skin disease that significantly impacts patients’ quality of life due to its ...
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis
Interleukin-17 (IL-17) has emerged as a key cytokine at the intersection of inflammation and thrombosis, potentially playi...
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress
Sepsis-Associated Encephalopathy (SAE) is a severe neurological complication of sepsis, where neuroinflammation plays a cr...
Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study
Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study
Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recogn...
Mechanistic study on the inhibition of triple-negative breast cancer progression by LncRNA TFAP2A-AS1 through the regulation of miR-6892/PHGDH
Mechanistic study on the inhibition of triple-negative breast cancer progression by LncRNA TFAP2A-AS1 through the regulation of miR-6892/PHGDH
The roles of long non-coding RNAs (lncRNAs) in the progression of various human tumors have been extensively studied. Howe...
The role of absent in melanoma 2 (AIM2) in cardiovascular diseases
The role of absent in melanoma 2 (AIM2) in cardiovascular diseases
Cardiovascular diseases (CVDs) are a group of conditions that significantly affect human health and are among the leading ...
Histamine regulates the activity and the expression of the Na/H exchanger (NHE)3 in human epithelial HK-2 cells
Histamine regulates the activity and the expression of the Na/H exchanger (NHE)3 in human epithelial HK-2 cells
Investigate the potential role of histamine and its receptors on the functional expression of the sodium/hydrogen (Na+/H+)...
Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives
Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives
Itaconate, a mitochondrial metabolite generated from cis-aconitate via IRG1 (ACOD1), has emerged as a key immunometabolic ...
Cannabinoids in preclinical research of sepsis: a scoping review
Cannabinoids in preclinical research of sepsis: a scoping review
Sepsis is a global health problem that ends millions of lives and costs billions of dollars in treatment and management ev...
Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context
Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context
Traumatic spinal cord injury (SCI) is a severe clinical challenge, often leading to long-term sensory, motor, and autonomi...
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression
Xiaoqinglong Decoction (XQLD) is a traditional oriental medicine. Modified- Xiaoqinglong Decoction (M-XQLD) was establishe...
The impact of aspirin on PD-L1 expression and alteration of M2 polarization in non-small cell lung cancer
The impact of aspirin on PD-L1 expression and alteration of M2 polarization in non-small cell lung cancer
Although aspirin is one of the best characterized drugs for the therapeutic effects on coagulation and inflammation, there...
Tuberculosis-infected macrophage exosomal miR-125b-5p induces osteoporosis by targeting IGF2 through the PI3K/AKT pathway
Tuberculosis-infected macrophage exosomal miR-125b-5p induces osteoporosis by targeting IGF2 through the PI3K/AKT pathway
Tuberculosis (TB) is a major infectious disease that can lead to systemic complications, including osteoporosis, particula...
A pain from the nose to the head: neurological commitment during long COVID
A pain from the nose to the head: neurological commitment during long COVID
Long COVID is a debilitating illness with multi-systemic symptoms that affects at least 10% of individuals who have had CO...
ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
Optogenetics allows a precise control of a vast variety of cellular processes in excitable and non-excitable cells, in par...
Expression and Stabilization of Recombinant Human C3aR Receptor
Expression and Stabilization of Recombinant Human C3aR Receptor
The complement system is an important part of the immune system that controls the body’s defense against pathogens. ...
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
The need for new effective compounds that can serve as prototype drugs for the treatment of viral infections and various t...
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
This paper analyzes the structural and functional organization of mitochondria. It is shown that deformation of membrane l...
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
In this work we aimed to investigate in silico the influence of the common experimental factors on the determination of th...
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a multifactorial disorder, with a high socioeconomic impact, characterized by chronic ab...
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
The class of G protein-coupled receptors (GPCRs) represents a ubiquitous family of membrane proteins that selectively inte...
Line Tension of Pore Edge in Membrane on Solid Support
Line Tension of Pore Edge in Membrane on Solid Support
Controlled formation of through pores in bilayer lipid membranes is a key stage of various biotechnological techniques. Ex...
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
The work is devoted to the mathematical modeling of the regulation of electron and proton transport in the thylakoid membr...
Recombinant Protein Biosensors of Cell Membrane Lipids
Recombinant Protein Biosensors of Cell Membrane Lipids
Specific patterns of lipid distribution in cell membranes determine their structural and signaling roles and ensure the in...
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
This study demonstrates the effect of the rhodocyanine derivative MKT-077 on the function of isolated mitochondria from mo...
Load More
format_indent_increase