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ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
Optogenetics allows a precise control of a vast variety of cellular processes in excitable and non-excitable cells, in par...
Expression and Stabilization of Recombinant Human C3aR Receptor
Expression and Stabilization of Recombinant Human C3aR Receptor
The complement system is an important part of the immune system that controls the body’s defense against pathogens. ...
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
The need for new effective compounds that can serve as prototype drugs for the treatment of viral infections and various t...
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
This paper analyzes the structural and functional organization of mitochondria. It is shown that deformation of membrane l...
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
In this work we aimed to investigate in silico the influence of the common experimental factors on the determination of th...
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a multifactorial disorder, with a high socioeconomic impact, characterized by chronic ab...
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
The class of G protein-coupled receptors (GPCRs) represents a ubiquitous family of membrane proteins that selectively inte...
Line Tension of Pore Edge in Membrane on Solid Support
Line Tension of Pore Edge in Membrane on Solid Support
Controlled formation of through pores in bilayer lipid membranes is a key stage of various biotechnological techniques. Ex...
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
The work is devoted to the mathematical modeling of the regulation of electron and proton transport in the thylakoid membr...
Recombinant Protein Biosensors of Cell Membrane Lipids
Recombinant Protein Biosensors of Cell Membrane Lipids
Specific patterns of lipid distribution in cell membranes determine their structural and signaling roles and ensure the in...
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
This study demonstrates the effect of the rhodocyanine derivative MKT-077 on the function of isolated mitochondria from mo...
Comparison of Functional and Proliferative Activity of hTERT-NK and iCasp9-NK Cells
Comparison of Functional and Proliferative Activity of hTERT-NK and iCasp9-NK Cells
Cancer progression is often accompanied with the acquisition of functional anergy by natural killer (NK) cells and their a...
Thermodynamics of a Lipid Membrane with Curvature
Thermodynamics of a Lipid Membrane with Curvature
The work considers the transverse bending of the surface of a bilayer lipid membrane and the lateral pressure profile in t...
Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
The ability of NK cells to establish antigen-specific responses has been demonstrated in various infections. NK cell recep...
Formation of Pores in Membranes Asymmetrical in Lipid Composition of Monolayers
Formation of Pores in Membranes Asymmetrical in Lipid Composition of Monolayers
Plasma membranes perform a barrier function in cells, preventing free exchange between the external environment and the in...
Effect of Carbon Monoxide on ATP-Evoked Activity in Rat Trigeminal Afferents
Effect of Carbon Monoxide on ATP-Evoked Activity in Rat Trigeminal Afferents
Carbon monoxide (CO) is an endogenous molecule that plays a regulatory role in a number of physiological and pathological ...
Wide-Angle X-Ray Scattering Comparative Analysis of Haloarchaeal Purple and Claret Membranes
Wide-Angle X-Ray Scattering Comparative Analysis of Haloarchaeal Purple and Claret Membranes
We present the results of the study of the structural distinctions between the purple membrane (PM) of Halobacterium salin...
Evaluation of the Effect of Geometrical Configuration and Charge of Opioid Antagonists on Their Binding to Receptors
Evaluation of the Effect of Geometrical Configuration and Charge of Opioid Antagonists on Their Binding to Receptors
The effect of the geometric configuration and charge of membrane opioid receptor (OR) agonists and antagonists on binding ...
The Protective Role of Mangiferin and -Cinnamic Acid against Oxidative Stress in Wild Type and Mutant Strains
The Protective Role of Mangiferin and -Cinnamic Acid against Oxidative Stress in Wild Type and Mutant Strains
During cellular metabolism, reactive oxygen species and nitrogen species are produced which inherently results in oxidativ...
Optogenetic enzymes: A deep dive into design and impact
Optogenetically regulated enzymes offer unprecedented spatiotemporal control over protein activity, intermolecular interac...
Frustration, dynamics, and catalysis
The first proposal of the origins of the catalytic power of enzymes came almost 100 years ago, when Haldane posited that e...
Global dynamics behind enzyme catalysis, evolution, and design
Enzymes are inherently dynamic systems, with their catalytic efficiency closely tied to coordinated internal motions that ...
Generative AI techniques for conformational diversity and evolutionary adaptation of proteins
The advent of AlphaFold and consumer large language models have elicited unprecedented development of artificial intellige...
Functional sub-states link conformational landscapes and protein evolution
The intrinsic conformational flexibility of proteins creates structural heterogeneity, giving rise to conformational ensem...
Artificial intelligence in therapeutic antibody design: Advances and future prospects
The global pharmaceutical market is increasingly driven by antibody-based therapeutics and various antibody-integrated mod...
Editorial overview: Protein folding and binding — With a little help from AI
Yana Bromberg received her PhD in Biomedical Informatics from Columbia University (NYC, USA). She then joined the State Un...
HDX-MS in micelles and membranes for small molecule and biopharmaceutical development
While protein characterisation is critical for continuing drug discovery and development, many techniques fall short of ca...
The influence of lipids and biological membranes on the conformational equilibria of GPCRs: Insights from NMR spectroscopy
G protein-coupled receptors (GPCRs) are crucial sensory integral membrane proteins. Earlier structural and biophysical stu...
Review: Membrane protein nanodiscs for antibody discovery
Membrane proteins, which make up approximately 30% of all proteins encoded by the human genome, represent more than 60% of...
HIV-1 gp160 in nanodiscs: Unravelling structures and guiding vaccine design
The HIV-1 gp160 trimer is a crucial mediator of viral entry and a primary target in HIV vaccine design, as numerous broadl...
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