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Apical constriction in morphogenesis: From actomyosin architecture to regulatory networks
Apical constriction is a key morphogenetic process driving tissue remodelling throughout life, including early development...
Nuclear biophysics: Spatial coordination of transcriptional dynamics?
A key step in gene expression is transcription — the synthesis of RNA using genomic DNA as a template. A vast amount is kn...
Macropinocytosis: Molecular mechanisms and regulation
Macropinocytosis is an evolutionarily conserved form of endocytosis in which cells non-selectively engulf extracellular fl...
Signals from the extracellular matrix: Region- and sex-specificity in cardiac aging
During aging, the cardiac extracellular matrix (ECM) undergoes gradual remodeling that reduces the heart's ability to func...
Mitotic signalling in progenitor cells: Integrating cell division with cell specification
The cell cycle is the fundamental process of cell duplication, essential for growth, development, and tissue homeostasis i...
New players on lipid droplets: Their regulations and functions
Lipid droplets (LDs) are highly conserved organelles found across a wide range of organisms, from prokaryotic to eukaryote...
Chromosomal instability in development and disease: Beyond cancer evolution
Chromosomal instability (CIN), an increased rate of changes in chromosome structure and number, has been classically assoc...
RAS/ERK signaling and PLK1: Coordinating developmental regulation and disease mechanisms
The RAS/ERK signaling pathway is a critical regulator of cellular processes such as proliferation, differentiation, and su...
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study
Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signal...
“Cancer progression through systemic signaling viewed from Drosophila”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
E-Cadherin: A conductor of cellular signaling
Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers ...
From brain-sparing to prioritised tumour growth: Insights into tumour-host interactions
It is increasingly recognized that cellular responses to their environment are shaped not only by their genetic compositio...
Mechanisms of left–right symmetry breaking across scales
Establishment of left–right (LR) asymmetry relies on a multistep interplay of molecular signaling and physical processes. ...
Arp2/3-complex regulation – Novel insights and open questions
Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolate...
Controlling cell architecture with protein design
Cells depend on a complex and precisely regulated subcellular organization, largely driven by the cytoskeleton and motor p...
Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity
The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (NaV)...
Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms
Cell biologists use a severely undersampled population of eukaryotes as model organisms to infer cellular processes across...
Signaling mechanisms in the reactivation of quiescent neural stem cells in Drosophila
Neural stem cells (NSCs) play a central role in the nervous system development and regeneration. In the adult mammalian br...
Cancer-associated fibroblasts as mediators of tissue microenvironment remodeling in cancer
Tumors are complex and dynamic ecosystems comprised of multiple cell populations that co-evolve over the course of disease...
Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
Adenosine is a ubiquitous endogenous molecule capable of influencing several pathophysiological aspects. The adenosine sys...
A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
Non-communicable chronic diseases are characterized by low-grade inflammation and oxidative stress. Extensive research has...
Correction: Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Correction: Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes
Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes
The organic cation transporter 3 (OCT3) is a ubiquitous transporter that carries both endogenous and exogenous substrates,...
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
Clinical research has identified stomach dysmotility as a common feature of obesity. However, the specific mechanisms driv...
Synergy between microtubule and actin networks in centrosome positioning
Centrosome positioning is important for cellular function, but the exact forces and spatial distribution that underly accu...
Surveilling ribosome biogenesis
Eukaryotic ribosomal quality control degrades faulty ribosomal assemblies, but precise mechanisms to target defective pre-...
Grow up, beta cells
Mitochondrial impairment, particularly in beta cells, is closely associated with metabolic disorders such as type 2 diabet...
Light microscopy reporting for reproducibility
We announce a cross-journal pilot at Nature Portfolio journals with a goal of implementing standardized light and fluoresc...
Cytoplasmic control of spindle architecture
Cytoplasmic control of spindle architecture
Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by ...
Organelle conversations drive ferroptosis
Organelle conversations drive ferroptosis
Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research ha...
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