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The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, charac...
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
Metastasis is a major contributor to treatment failure and death in urological cancers, representing an important biomedic...
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (C...
In vivo manufacture and manipulation of CAR-T cells for better druggability
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation requi...
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicat...
Glioblastoma stem cell metabolism and immunity
Glioblastoma stem cell metabolism and immunity
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire...
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Atezolizumab (TECENTRIQ®) and nivolumab (OPDIVO®) are both immunotherapeutic indications targeting programmed ce...
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and ethnic distribution. The interplay betw...
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
MCM10 plays a vital role in genome duplication and is crucial for DNA replication initiation, elongation, and termination....
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate i...
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and ...
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and main causes of cancer-related deaths worldwid...
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignanc...
CAR T-cells for pediatric solid tumors: where to go from here?
CAR T-cells for pediatric solid tumors: where to go from here?
Despite the great success that chimeric antigen receptor (CAR) T-cells have had in patients with B-cell malignancies and m...
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Colorectal cancer (CRC) is a common cancer, with a concerning rise in early-onset CRC cases, signalling a shift in disease...
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Cellular plasticity refers to the ability of cells to change their identity or behavior, which can be advantageous in some...
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
Glucagon-like peptide-1 receptor (GLP-1R) agonists have garnered significant attention for their therapeutic potential in ...
Biography—Mathieu Boissan, Pharm.D., Ph.D
Biography—Mathieu Boissan, Pharm.D., Ph.D
Mathieu Boissan, Pharm.D., Ph.D.Mathieu Boissan, Pharm.D., Ph.D. is a cellular biolo...
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes o...
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Recent therapeutic advances have significantly uplifted the quality of life in breast cancer patients, yet several impedim...
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Plasticity of phenotypic traits refers to an organism’s ability to change in response to environmental stimuli. As a...
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME...
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Cellular plasticity and therapy resistance are critical features of pancreatic cancer, a highly aggressive and fatal disea...
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitoch...
The emerging roles of histone demethylases in cancers
The emerging roles of histone demethylases in cancers
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantia...
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function change...
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes s...
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and ep...
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Circular RNAs (circRNAs) are a member of non-coding RNAs with no ability in encoding proteins and their aberrant dysregula...
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been key challenges to effective t...
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