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Advancements in gene therapies targeting mutant KRAS in cancers
Advancements in gene therapies targeting mutant KRAS in cancers
Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically...
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containin...
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastas...
The diversity of natural killer cell functional and phenotypic states in cancer
The diversity of natural killer cell functional and phenotypic states in cancer
The role of natural killer (NK) cells as immune effectors is well established, as is their utility as immunotherapeutic ag...
Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art
Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art
The management of bone metastases (BoM) requires a multidisciplinary approach to prevent complications, necessitating upda...
Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives
Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives
CT chest scans are commonly performed worldwide, either in routine clinical practice for a wide range of indications&n...
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy
Immune checkpoint inhibitors (ICIs) have improved clinical outcomes in patients with non-small cell lung cancer (NSCLC) la...
Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer
Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer
Cellular plasticity and the ability to avoid terminal differentiation are hallmarks of cancer. Here, we review the evidenc...
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair
The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the ...
Mitochondrial alterations and signatures in hepatocellular carcinoma
Mitochondrial alterations and signatures in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer worldwide. Its primary risk factors are chr...
Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis
Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis
The efficacy and off-target effects of immune checkpoint inhibitors (ICI) in cancer treatment vary among patients. Monocyt...
Ferroptosis: iron release mechanisms in the bioenergetic process
Ferroptosis: iron release mechanisms in the bioenergetic process
Ferroptosis, an iron-dependent form of cell death, has been the focus of extensive research over the past decade, leading ...
Epigenetic drugs in cancer therapy
Epigenetic drugs in cancer therapy
Genetic and epigenetic modifications of DNA are involved in cancer initiation and progression. Epigenetic modifications ch...
The functions and modifications of tRNA-derived small RNAs in cancer biology
The functions and modifications of tRNA-derived small RNAs in cancer biology
Recent progress in noncoding RNA research has highlighted transfer RNA-derived small RNAs (tsRNAs) as key regulators of ge...
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease bio...
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Since 1976, Surveillance Epidemiology End Results (SEER) began collecting ethnicity data for the National Cancer Institute...
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Lee, J. Y., Bays, D. J., Savage, H. P., & Baumler, A. J. (2024). The human gut microbiome in health and disease: Time ...
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, charac...
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
Metastasis is a major contributor to treatment failure and death in urological cancers, representing an important biomedic...
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (C...
In vivo manufacture and manipulation of CAR-T cells for better druggability
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation requi...
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicat...
Glioblastoma stem cell metabolism and immunity
Glioblastoma stem cell metabolism and immunity
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire...
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Atezolizumab (TECENTRIQ®) and nivolumab (OPDIVO®) are both immunotherapeutic indications targeting programmed ce...
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and ethnic distribution. The interplay betw...
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
MCM10 plays a vital role in genome duplication and is crucial for DNA replication initiation, elongation, and termination....
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate i...
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and ...
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and main causes of cancer-related deaths worldwid...
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignanc...
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