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Inhibiting lipid droplet biogenesis enhances host protection against hypervirulent infections
Inhibiting lipid droplet biogenesis enhances host protection against hypervirulent infections
Hypervirulent Klebsiella pneumoniae (hvKp), an emerging Kp subtype, has become a serious global pathogen. However, the inf...
Construction and evaluation of glycoprotein-based nucleic acid vaccines for Marburg virus
Construction and evaluation of glycoprotein-based nucleic acid vaccines for Marburg virus
Marburg virus (MARV) is a zoonotic virus that can infect humans and non-human primates (NHPs) and lead to a fatal Marburg ...
Significance of diagnostic and therapeutic potential of serum endothelial and inflammatory biomarkers in defining disease severity of dengue infected patients
Significance of diagnostic and therapeutic potential of serum endothelial and inflammatory biomarkers in defining disease severity of dengue infected patients
Dengue virus (DENV) mediated disease severity leads to fatality among infected patients. Immune sentinels recognize DENV t...
Proportions of IgA antibodies targeting glycosylated epitopes of secreted mucinase YghJ in initial plasmablast response differ from salivary and intestinally secreted IgA
Proportions of IgA antibodies targeting glycosylated epitopes of secreted mucinase YghJ in initial plasmablast response differ from salivary and intestinally secreted IgA
Mucosal infections normally cause an immune response including activation of antigen-specific B cells in regional mucosa-a...
Deciphering long-term immune effects of HIV-1/SARS-CoV-2 co-infection: a longitudinal study
Deciphering long-term immune effects of HIV-1/SARS-CoV-2 co-infection: a longitudinal study
While the general immune response to Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is well-understood, the ...
In silico identification and ex vivo evaluation of peptides restricted to HLA-A*02, HLA-A*24 and HLA-B*35 alleles in human PBMC from a Colombian population
In silico identification and ex vivo evaluation of peptides restricted to HLA-A*02, HLA-A*24 and HLA-B*35 alleles in human PBMC from a Colombian population
Toxoplasma gondii infects approximately 30% of the population, and there is currently no approved vaccine. Identifying imm...
Dissemination of and is associated with class 1 integrons in clinical isolates from Portugal
Dissemination of and is associated with class 1 integrons in clinical isolates from Portugal
\nKlebsiella pneumoniae is a common pathogen of healthcare-associated infections expressing a plethora of antimicrobial re...
Cytolethal distending toxin-producing clinical isolates from Mexican children harbor different types causing CDT-induced epithelial pathological phenotypes
Cytolethal distending toxin-producing clinical isolates from Mexican children harbor different types causing CDT-induced epithelial pathological phenotypes
Cytolethal distending toxins (CDTs), encoded by cdtABC genes, have DNase activity leading to cellular and nuclear distenti...
The efficacy of antimicrobial therapies in the treatment of mixed biofilms formed between and during epithelial cell infection in the aspiration pneumonia model
The efficacy of antimicrobial therapies in the treatment of mixed biofilms formed between and during epithelial cell infection in the aspiration pneumonia model
Aspiration pneumonia is a serious respiratory condition, which is particularly prevalent in patients with dysphagia, neuro...
Fungal infection monitoring on corneal epithelium ex vivo model and its collection over polyethersulfone membrane for detecting and
Fungal infection monitoring on corneal epithelium ex vivo model and its collection over polyethersulfone membrane for detecting and
In this paper we report a human ex vivo model of Aspergillus fumigatus and Candida albicans infection of the cornea. We de...
Protective antibodies against enterotoxigenic are generated from heat-labile toxoid vaccination and exhibit subject- and vaccine-specific diversity
Protective antibodies against enterotoxigenic are generated from heat-labile toxoid vaccination and exhibit subject- and vaccine-specific diversity
Heat-labile toxin (LT) from enterotoxigenic Escherichia coli (ETEC) is an important pathogenic protein. Anti-LT antibodies...
Dose-dependent M2 macrophage polarization induced by promotes lung cancer cell growth via arginine-ornithine-cycle activation
Dose-dependent M2 macrophage polarization induced by promotes lung cancer cell growth via arginine-ornithine-cycle activation
It is now widely accepted that lungs are colonized by diverse microbes. Dysbiosis of the lung microbiota has been found to...
Production of recombinant electron transfer flavoprotein beta subunit protein and its application in a lateral flow assay for early diagnosis of leptospirosis
Production of recombinant electron transfer flavoprotein beta subunit protein and its application in a lateral flow assay for early diagnosis of leptospirosis
Leptospirosis is a major cause of acute febrile illness, often presenting with non-specific symptoms that can lead to misd...
miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort
miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort
Dengue virus (DENV) is a global health threat, with approximately 390 million infections annually, ranging from m...
Stability of cytokine, cellular and clinical response to the intravenous LPS challenge repeated after one year: a healthy volunteer trial
Stability of cytokine, cellular and clinical response to the intravenous LPS challenge repeated after one year: a healthy volunteer trial
Whether the magnitude of individual cytokine, cellular, and clinical responses to the intravenous lipopolysaccharide (LPS)...
Deferiprone inhibits virulence and biofilm formation in
Deferiprone inhibits virulence and biofilm formation in
Burkholderia cenocepacia, an opportunistic pathogen, poses a significant threat to human health, necessitating the discove...
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Group A Streptococcus (GAS) is a pathogen that is capable of colonizing various infection sites and can potentially elicit...
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Leishmania donovani is the causative agent of the fatal visceral leishmaniasis (VL) disease in humans in the tropical regi...
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Community-acquired pneumonia (CAP) is a significant health threat for adults. Although conjugate vaccines have reduced pne...
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical pr...
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis, a lethal pathogen in human history, causes millions of deaths annually, which demands the deve...
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising se...
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mort...
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge is best known for the promotion of studies demonstrating the transmission of all manner of infections, bu...
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Outbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mp...
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated with necrotizing infections. After binding to...
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a globally significant vector-borne pathogen with no internationally-lice...
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Campylobacter and invasive non-typhoidal Salmonella (iNTS) are among the most common causative agents of gastroenteritis w...
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a deadly, highly contagious disease in both ...
Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment
Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment
Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an opti...
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