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Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line
Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Capecitabine is a key chemotherap...
Molecular docking, microwave-assisted synthesis, characterization, and preliminary evaluation of the anti-microbial activity of new sulfonamide derivatives of the 1, 2, 4-triazole-3-thiol ring system
Molecular docking, microwave-assisted synthesis, characterization, and preliminary evaluation of the anti-microbial activity of new sulfonamide derivatives of the 1, 2, 4-triazole-3-thiol ring system
A new sulfonamide derivative containing a 1,2,4-Triazole-3-thiol ring was synthesized and characterized using FT-IR and 1H...
Synthesis, characterization, preliminary molecular docking, pharmacological activity, and ADME studies of some new pyrazoline derivatives as anti-breast cancer agents
Synthesis, characterization, preliminary molecular docking, pharmacological activity, and ADME studies of some new pyrazoline derivatives as anti-breast cancer agents
This work studied the anti-breast cancer activities of pyrazoline-containing benzenesulfonamides (6–10) in vitro and silic...
Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids
Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids
A group of new amidrazone compounds that include a quinoline component was produced through the reaction of hydrazonyl chl...
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Cancer, a formidable disease with a significant mortality rate, continues to claim the lives of thousands of individuals a...
Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides
Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides
According to the recent studies bezylcarboxamide fragment attached to the thiophene ring of thieno[2,3-d]pyrimidine is ben...
Regulation and control of the use of Cannabis and Cannabidiol in „novel foods”
Regulation and control of the use of Cannabis and Cannabidiol in „novel foods”
Cannabis sativa L. is a medicinal plant from family Cannabaceae with many pharmacological activities. The recent appearanc...
Separation and analysis of triazole antifungal in biological matrices by liquid chromatography: a review
Separation and analysis of triazole antifungal in biological matrices by liquid chromatography: a review
Invasive fungal infections cause serious illness and death worldwide. Long-term therapeutic and preventative use of antifu...
Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib
Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib
Millions of publications and thousands of clinical trials have not led to the discovery of an effective treatment for COVI...
In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues
In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues
In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activi...
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 2: Antineoplastic and immunomodulating agents
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 2: Antineoplastic and immunomodulating agents
There are drugs that require special storage in Bulgarian pharmacies as well as extra caution during the dispensing proces...
Molecular docking analysis of ginger (Zingiber officinale) on dopamine compare to bupropion as smoking cessation
Molecular docking analysis of ginger (Zingiber officinale) on dopamine compare to bupropion as smoking cessation
Tobacco use continues to be the leading cause of preventable death worldwide. Smoking is highly addictive because nicotine...
Phytochemical profiling and cardioprotective activity of Vernonia amygdalina ethanol extract (VAEE) against ISO-induced cardiotoxicity in rats
Phytochemical profiling and cardioprotective activity of Vernonia amygdalina ethanol extract (VAEE) against ISO-induced cardiotoxicity in rats
Cardiovascular disorder is the leading cause death in the world, one of them are acute myocardial infarction (AMI) which a...
Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage...
The complex mechanism of developing trust in pharmacy
The complex mechanism of developing trust in pharmacy
Indicators of the success in pharmaceutical services at pharmacy can be seen from customer satisfaction which is influence...
Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L.
Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L.
Allium cepa L. is commonly used as a vegetable, spice, and in traditional medicine. In traditional medicine, A. cepa is ap...
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 1: Medicines acting on cardiovascular and nervous system
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 1: Medicines acting on cardiovascular and nervous system
Some medicines require special storage in Bulgarian pharmacies due to serious adverse reactions that may be even life-thre...
Development and validation of analytical procedure for analysis of Amoxiciline, Metronidazole and Omeprazole, used as anti- Helicobacter pylori agents alone and in mixture
Development and validation of analytical procedure for analysis of Amoxiciline, Metronidazole and Omeprazole, used as anti- Helicobacter pylori agents alone and in mixture
Background: The contemporary treatment of ulcerogenic diseases and gastroesophageal reflux disease is related usually to a...
An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development
An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development
Typhonium flagelliforme, a plant known for its medicinal properties, has numerous benefits in the treatment of certain dis...
The effect of a small polyphenolic and terpenoids phytochemical constituent on curing and preventing of Covid-19 infections
The effect of a small polyphenolic and terpenoids phytochemical constituent on curing and preventing of Covid-19 infections
Covid-19 spreading have caused millions of deaths worldwide and caused sever economic shrinking resulted in high levels of...
Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru
Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru
Epilepsy is the most common neurological disorder with a worldwide incidence of 20% and a treatment failure rate of 25–30%...
Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol
Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol
A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). ...
Astragalus glycyphyllos L.: Phytochemical constituents, pharmacology, and biotechnology
Astragalus glycyphyllos L.: Phytochemical constituents, pharmacology, and biotechnology
Astragalus glycyphyllos is a widely distributed plant found in Bulgaria that has been used in the folk medicine of the cou...
Assessment of patients’ awareness on drugs use and adherence to drug therapy as an element of Medication Review service
Assessment of patients’ awareness on drugs use and adherence to drug therapy as an element of Medication Review service
The administration of an excessive amount of or unnecessary drugs is a prerequisite for numerous drug-related problems, no...
Nanoemulsions as medicinal components in insoluble medicines
Nanoemulsions as medicinal components in insoluble medicines
Background: Medicine’s success relies on solubility, which is the process of dissolving a solid substance in a fluid phase...
Formononetin suppresses hyperglycaemia through activation of GLUT4-AMPK pathway
Formononetin suppresses hyperglycaemia through activation of GLUT4-AMPK pathway
Background: Formononetin (FMN) is a flavonoid that has different pharmacological effects. Thus, the anti-diabetic effects ...
Results of the assessment of the level of literacy of the Ukrainian population in matters of health and use of medicines
Results of the assessment of the level of literacy of the Ukrainian population in matters of health and use of medicines
An instrument for assessing the health literacy of the population in matters of health and use of medicines was developed ...
Formulation and evaluation of retinyl palmitate and vitamin E nanoemulsion for skin care
Formulation and evaluation of retinyl palmitate and vitamin E nanoemulsion for skin care
Background: Improving and maintaining the skin integrity and health are the most essential targets in long-term care. The ...
Fabrication of blended chitosan nanofibers by the free surface wire electrospinning
Fabrication of blended chitosan nanofibers by the free surface wire electrospinning
Nanofibers are fibers with diameters in the nanometer range. They are characterized by their high surface area to volume r...
Technological strategies for the preparation of lipid nanoparticles: an updated review
Technological strategies for the preparation of lipid nanoparticles: an updated review
The concept of improving drug biopharmaceutical properties by proper selection of delivery system should begin with a rati...
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