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Revealing gene function with statistical inference at single-cell resolution
Revealing gene function with statistical inference at single-cell resolution
Single-cell and spatial molecular profiling assays have shown large gains in sensitivity, resolution and throughput. Apply...
Decoding the language of chromatin modifications with MARCS
Decoding the language of chromatin modifications with MARCS
In this Tools of the Trade article, Andrey Tvardovskiy and Saulius Lukauskas introduce the web resource MARCS, which offer...
Publisher Correction: How germ granules promote germ cell fate
Authors and AffiliationsWhitehead Institute for Biomedical Research, Cambridge, MA, USAMelissa C. Pamula & Ruth Lehman...
Decoding protein–RNA interactions using CLIP-based methodologies
Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expr...
Programmable DNA rearrangements using bridge RNAs
Programmable DNA rearrangements using bridge RNAs
Two studies in Nature reveal the mechanistic and structural properties of a family of mobile genetic elements that can be ...
Evolution and regulation of animal sex chromosomes
Evolution and regulation of animal sex chromosomes
Animal sex chromosomes typically carry the upstream sex-determining gene that triggers testis or ovary development and, in...
Epigenetic editing works like a CHARM
Epigenetic editing works like a CHARM
Neumann, Bertozzi et al. describe a novel epigenetic editor termed CHARM and report its use to silence prion protein expre...
Chromosomal instability as a driver of cancer progression
Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural and numerical chromosomal a...
Dynamics of ER stress-induced gene regulation in plants
Dynamics of ER stress-induced gene regulation in plants
Endoplasmic reticulum (ER) stress is a potentially lethal condition that is induced by the abnormal accumulation of unfold...
The evolution of modifier genes
In this Journal Club, Yoav Ram recalls how he reconciled results from his own research with the reduction principle throug...
Global genomic diversity for All of Us
Global genomic diversity for All of Us
A publication in Nature reports the data release of around 245,000 clinical-grade whole-genome sequences as part of the NI...
AIRE targets poised promoters enriched for Z-DNA
AIRE targets poised promoters enriched for Z-DNA
A paper in Nature reports a ‘Z-DNA-anchored’ model for the target specificity of the transcription factor AIRE...
Building a catalogue of short tandem repeats in diverse populations
Reflecting on the importance of short tandem repeats (STRs) in population genetics, Ning Xie highlights a 2023 publication...
Genetic variation across and within individuals
Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germl...
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions betwe...
Decoding human genetic variation using a synthetic paradigm
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of &...
Divergence and conservation of the meiotic recombination machinery
Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during ...
Including diverse populations enhances the discovery of type 2 diabetes loci
Segun Fatumo highlights a paper by Mahajan et al. that uses a multi-ancestry genome-wide association studies approach to u...
Mouse genome rewriting with human DNA for disease modelling
Mouse genome rewriting with human DNA for disease modelling
Zhang et al. describe mSwAP-In, a platform for large-scale, efficient, biallelic and ‘scarless’ genome editing...
Weaponized genomics: potential threats to international and human security
Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussi...
Context-specific functions of chromatin remodellers in development and disease
Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human gen...
SWI/SNF function compensated by another chromatin remodeller
SWI/SNF function compensated by another chromatin remodeller
Martin et al. report that the EP400/TIP60 complex can compensate for function of the SWI/SNF complex to remodel chromatin ...
Translating genomic advances into biodiversity conservation
Translating genomic advances into biodiversity conservation
A key action of the new Global Biodiversity Framework is the maintenance of genetic diversity in all species to safeguard ...
Interrogating epigenetic mechanisms with chemically customized chromatin
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated i...
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. S...
Controlling organoid gene expression with light
Controlling organoid gene expression with light
Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can...
De novo genes: from non-genic to genic
Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially univ...
A genetic atlas of the human blood proteome
A genetic atlas of the human blood proteome
Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for unders...
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencin...
WNT regulator controls stripe patterning
WNT regulator controls stripe patterning
Johnson et al. identify a WNT regulator that underlies the development and evolution of distinct colour patterning in the ...
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