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The Role of PET Imaging in Patients with Prion Disease: A Literature Review
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
Prion diseases are rare, rapidly progressive, and fatal incurable degenerative brain disorders caused by the misfolding of...
Multi-channel Small Animal Drug Metabolism Real-Time Monitoring Fluorescence System
Multi-channel Small Animal Drug Metabolism Real-Time Monitoring Fluorescence System
The data acquisition of drug metabolism analysis requires a lot of time and animal resources. However, there are often man...
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Gastro-entero-pancreatic neuroendocrine carcinomas (GEP-NECs) are an aggressive subgroup of neuroendocrine neoplasms (NENs...
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
To assess the prognostic value of pre-treatment [68Ga]Ga-PSMA-11 PET/CT and other baseline clinical characteristics in pre...
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
The current established technique for sentinel lymph node (SLN) biopsy is preoperative injection of 99mtechnetium-labeled ...
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
Immunoglobulins, both full-length antibodies and smaller antibody fragments, have long been regarded as effective platform...
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
A critical step in cell-based therapies is determining the exact position of transplanted cells immediately post-transplan...
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
We aimed to determine the test–retest repeatability of quantitative metrics based on the Patlak slope (PS) versus th...
Development of New CD38 Targeted Peptides for Cancer Imaging
Development of New CD38 Targeted Peptides for Cancer Imaging
Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emissi...
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT an...
Passing the Molecular Imaging and Biology Torch
Passing the Molecular Imaging and Biology Torch
I remember relaxing in a Seattle airport lounge in 2018, on my way back to Nashville ...
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Low frequency EPR can noninvasively detect endogenous free radical melanin in melanocytic skin lesions and could potential...
The Theranostic Optimization of PSMA-GCK01 Does Not Compromise the Imaging Characteristics of [99mTc]Tc-PSMA-GCK01 Compared to Dedicated Diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in Prostate Cancer
The Theranostic Optimization of PSMA-GCK01 Does Not Compromise the Imaging Characteristics of [99mTc]Tc-PSMA-GCK01 Compared to Dedicated Diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in Prostate Cancer
Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for th...
Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats
Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats
Hypoxia-inducible factor (HIF) drives transcription of critical hypoxia response genes, increasing the production of red b...
Identification of Optimal Tissue-Marking Dye Color for Pathological Evaluation in Fluorescence Imaging Using IRDye800CW
Identification of Optimal Tissue-Marking Dye Color for Pathological Evaluation in Fluorescence Imaging Using IRDye800CW
Fluorescence-guided surgery using a tumor-specific antibody-dye conjugate is useful in various cancer types. Fluorescence ...
Electron Spin Resonance Probe Incorporation into Bioinks Permits Longitudinal Oxygen Imaging of Bioprinted Constructs
Electron Spin Resonance Probe Incorporation into Bioinks Permits Longitudinal Oxygen Imaging of Bioprinted Constructs
Bioprinting is an additive manufacturing technology analogous to 3D printing. Instead of plastic or resin, cell-laden hydr...
Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy
Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy
Attenuated Salmonella typhimurium is a potential biotherapeutic antitumor agent because it can colonize tumors and inhibit...
The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
Preclinical studies showed the tryptophan analog PET radiotracer 1-(2-18F-fluoroethyl)-L-tryptophan (18F-FETrp) to accumul...
Quantitative and Qualitative Assessment of Urinary Activity of 18F-Flotufolastat-PET/CT in Patients with Prostate Cancer: a Post Hoc Analysis of the LIGHTHOUSE and SPOTLIGHT Studies
Quantitative and Qualitative Assessment of Urinary Activity of 18F-Flotufolastat-PET/CT in Patients with Prostate Cancer: a Post Hoc Analysis of the LIGHTHOUSE and SPOTLIGHT Studies
To evaluate the impact of urinary activity on interpretation of 18F-flotufolastat (18F-rhPSMA-7.3) PET/CT, we conducted a ...
Radiomics Based on Contrast-Enhanced CT for Recognizing c-Met-Positive Hepatocellular Carcinoma: a Noninvasive Approach to Predict the Outcome of Sorafenib Resistance
Radiomics Based on Contrast-Enhanced CT for Recognizing c-Met-Positive Hepatocellular Carcinoma: a Noninvasive Approach to Predict the Outcome of Sorafenib Resistance
The purpose of our project was to investigate the effectiveness of radiomic features based on contrast-enhanced computed t...
Imaging in Type 1 Diabetes, Current Perspectives and Directions
Imaging in Type 1 Diabetes, Current Perspectives and Directions
Type 1 diabetes (T1D) is characterized by the autoimmune-mediated attack of insulin-producing beta cells in the pancreas, ...
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
This study aimed to develop a biocompatible oximetric electron paramagnetic resonance (EPR) spin probe with reduced self-r...
Physiological Uptake Characteristics of Breast on 68Ga-FAPI-04 PET/CT
Physiological Uptake Characteristics of Breast on 68Ga-FAPI-04 PET/CT
Gallium 68 (68Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT is sensitive on breast cancer staging, but...
Correction to: Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects
Correction to: Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects
School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University, Beijing, 10...
MIB Guides: Preclinical Radiopharmaceutical Dosimetry
MIB Guides: Preclinical Radiopharmaceutical Dosimetry
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and ther...
Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. Th...
Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use
Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use
Progress toward developing a novel radiocontrast agent for determining pO2 in tumors in a clinical setting is described. T...
Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability
Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability
Positron emission tomography (PET) image quality can be improved by higher injected activity and/or longer acquisition tim...
Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
Critical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of ...
Assessment of Brain Tumour Perfusion Using Early-Phase 18F-FET PET: Comparison with Perfusion-Weighted MRI
Assessment of Brain Tumour Perfusion Using Early-Phase 18F-FET PET: Comparison with Perfusion-Weighted MRI
Morphological imaging using MRI is essential for brain tumour diagnostics. Dynamic susceptibility contrast (DSC) perfusion...
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