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Oral bacteria accelerate pancreatic cancer development in mice
Oral bacteria accelerate pancreatic cancer development in mice
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Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Chronic obstructive pulmonary disease (COPD) is most often caused by long-term cigarette smoke (CS) inhalation and include...
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Serum antibodies to the autoantigen transglutaminase 2 (TG2) are increasingly harnessed to diagnose coeliac disease. Diagn...
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
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Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
Video Abstract Disclaimer: this video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The...
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
Tumour-reactive T cells infiltrating solid tumours are often rendered exhausted, a cell differentiation state characterise...
Is acute necrotising pancreatitis a chronic disease?
Is acute necrotising pancreatitis a chronic disease?
Acute pancreatitis (AP) is a common disease with an annual incidence of 34 (23–49) per 100 000 population.1 Patients with ...
Ferritin--a promising biomarker in MASLD
Ferritin--a promising biomarker in MASLD
Human ferritins are expressed in essentially all cells of the human body. From an evolutionary perspective, human ferritin...
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
MessageEndoscopic neoplasia detection in inflammatory bowel disease (IBD) remains challenging. We developed and validated ...
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Chronic liver diseases are prevalent, particularly among patients with type 2 diabetes, who have a higher incidence of met...
Unusual cause of abdominal pain
Unusual cause of abdominal pain
An 18-year-old woman presented with a 4-day history of worsening abdominal pain. Physical examination revealed tenderness ...
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
IntroductionBarrett’s oesophagus (BO) is a precursor lesion for oesophageal adenocarcinoma (OAC) and provides an opportuni...
Fibrosis in IBD: from pathogenesis to therapeutic targets
Fibrosis in IBD: from pathogenesis to therapeutic targets
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Toning down the role of eosinophils in eosinophilic oesophagitis
Toning down the role of eosinophils in eosinophilic oesophagitis
Eosinophilic oesophagitis (EoE) is an immune-mediated disease of uncertain aetiology. The diagnosis of EoE relies on the e...
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
We thank Ludvigsson for his interest in our work and for providing additional insights. As noted, our joint works implicat...
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Oesophageal adenocarcinoma (OAC) is a devastating disease with an average 5-year survival of around 15%.1 Moreover, rates ...
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Recently, Lopes et al quantified the effect of modifiable lifestyle factors in inflammatory bowel disease (IBD) prevention...
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
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NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
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Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
The gastrointestinal ecosystem has received the most attention when examining the contributions of the human microbiome to...
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
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Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
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Diagnostic dilemma: a patient with diarrhoea
Diagnostic dilemma: a patient with diarrhoea
A Sudanese man in his early 40s was admitted to our tertiary healthcare centre with a 3-month history of abdominal pain, f...
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
IntroductionThe contribution of pancreatic cancer to global cancer-related mortality continues to increase, with an almost...
Wheat proteins as triggers of central nervous system inflammation
Wheat proteins as triggers of central nervous system inflammation
The role of diet in the initiation and progression of disease is one of the most exciting areas of research nowadays. Alth...
FAK scaffolds immune escape in pancreatic cancer
FAK scaffolds immune escape in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease in urgent need of improved therapy. A characteristic feat...
More than shots in the dark: driving vaccine efficacy in cirrhosis
More than shots in the dark: driving vaccine efficacy in cirrhosis
In advanced stages of the disease, liver cirrhosis is considered a systemic disease as its complications manifest on vario...
Thermal ablation after endoscopic mucosal resection of large colorectal polyps: not only the margins, but also the base?
Thermal ablation after endoscopic mucosal resection of large colorectal polyps: not only the margins, but also the base?
MessageThermal ablation of resection margins has been shown to reduce recurrence after endoscopic mucosal resection (EMR) ...
Monocyte phenotypic liquid biopsy for NASH and liver fibrosis diagnosis: a new kid on the block
Monocyte phenotypic liquid biopsy for NASH and liver fibrosis diagnosis: a new kid on the block
Clinical diagnosis, selection of patients in non-alcoholic steatohepatitis (NASH) clinical trials and evaluation of both d...
Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial
Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial
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