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PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
Melanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling incr...
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar...
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
The success of colon-targeted oral hybrid systems relies in the proper control over the release of the entrapped nanostruc...
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
The first line of glaucoma treatment focuses on reducing intraocular pressure (IOP) through the prescription of topical pr...
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of ...
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Allergic disease is a major global health concern that imposes significant life-altering and economic burdens on affected ...
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
To achieve precision and selectivity, anticancer compounds and nanoparticles (NPs) can be targeted with affinity ligands t...
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that...
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per y...
Lipid nanoparticles-based RNA therapies for breast cancer treatment
Lipid nanoparticles-based RNA therapies for breast cancer treatment
Breast cancer (BC) prevails as a major burden on global healthcare, being the most prevalent form of cancer among women. B...
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Fabry disease (FD) results from a lack of activity of the lysosomal enzyme α-Galactosidase A (α-Gal A), leading ...
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strate...
Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris
Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris
Acne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation an...
In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye
In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye
This study focused on the design of a thermoresponsive, nano-enabled vitreous substitute for the treatment of retinal dise...
Stimuli-responsive magnetic silica-poly-lactic-co-glycolic acid hybrid nanoparticles for targeted cancer chemo-immunotherapy
Stimuli-responsive magnetic silica-poly-lactic-co-glycolic acid hybrid nanoparticles for targeted cancer chemo-immunotherapy
Chemotherapy and immunotherapy are two important modalities in cancer management. However, due to multiple reasons, a mono...
Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy
Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy
Glioblastoma (GBM) stands as a highly aggressive and deadly malignant primary brain tumor with a median survival time of u...
Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery
Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery
Fisetin (FS) is a flavonoid that possesses antioxidant and anti-inflammatory properties against ulcerative colitis. FS sho...
Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy
Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy
Conventional drugs have been facing various drug delivery obstacles, including first-pass metabolism for oral medications,...
Cell-derived biomimetic nanoparticles for the targeted therapy of ALI/ARDS
Cell-derived biomimetic nanoparticles for the targeted therapy of ALI/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical critical diseases with high mor...
Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo
Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo
Targeted nanodelivery systems offer a promising approach to cancer treatment, including the most common cancer in women, b...
Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology
Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology
Microneedles (MNs) are micron-scale needles that are a painless alternative to injections for delivering drugs through the...
Exosome: From biology to drug delivery
Exosome: From biology to drug delivery
In recent years, different advancements have been observed in nanosized drug delivery systems. Factors such as stability, ...
ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes?
ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes?
The blood–brain barrier (BBB) poses a major obstacle in the treatment of all types of central nervous system (CNS) d...
Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis
Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis
Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone t...
Antibiotic resistance and tolerance: What can drug delivery do against this global threat?
Antibiotic resistance and tolerance: What can drug delivery do against this global threat?
Antimicrobial resistance and tolerance (AMR&T) are urgent global health concerns, with alarmingl...
Bibliometric and visualized analysis of cancer nanomedicine from 2013 to 2023
Bibliometric and visualized analysis of cancer nanomedicine from 2013 to 2023
Cancer nanomedicine has been an emerging field for drug development against malignant tumors during the past three decades...
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effe...
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
While considerable efforts have been made to develop new therapies, progress in the treatment of pancreatic cancer has so ...
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Cannabidiol (CBD) has gained significant attention as a complementary and alternative medicine due to its promising therap...
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Chronic and allergic rhinosinusitis impacts approximately 12% of the global population. Challenges in rhinosinusitis treat...
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