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Combination treatment for immune-mediated HIV remission
Combination treatment for immune-mediated HIV remission
In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of v...
Microplastics at heart of the problem
Microplastics at heart of the problem
Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiov...
A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providin...
Going the extra mile to increase vaccine uptake
Going the extra mile to increase vaccine uptake
Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine upta...
Large language models for reducing clinicians’ documentation burden
Large language models for reducing clinicians’ documentation burden
Evaluation of a clinical summarization method based on GPT-4 suggests that such models might reduce the documentation burd...
Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
The authors have determined that the cell line referred to as AT3 breast cancer in the paper is instead Lewis lung carcino...
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
These authors contributed equally: Leandro C Cerchietti, Eloisi C LopesDivision of Hematology and Oncology, Weill Cornell ...
Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness
Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness
Most suspected cholera cases are not tested for Vibrio cholerae. Integrating systematic testing into cholera surveillance ...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
Meningioma risk stratification with a targeted gene-expression biomarker
Meningioma risk stratification with a targeted gene-expression biomarker
A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningi...
11 clinical trials that will shape medicine in 2024
11 clinical trials that will shape medicine in 2024
Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine agains...
Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USASylvan C. Baca, Ji-Heui Seo, Matthew P. David...
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate...
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
KRAS G12C mutation is prevalent in ~4% of colorectal cancer (CRC) and is associated with poor prognosis. Divarasib, a KRAS...
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multice...
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of lif...
Monitoring medical AI device adoption
Monitoring medical AI device adoption
The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and l...
CT scans in young people and risk of hematological malignancies
CT scans in young people and risk of hematological malignancies
A study of nearly one million people who underwent a CT scan before 22 years of age finds that the radiation from CT scans...
Machine learning improves prediction of clinical outcomes for invasive breast cancers
Machine learning improves prediction of clinical outcomes for invasive breast cancers
A prognostic model for invasive breast cancer that is based on interpretable measurements of epithelial, stromal, and immu...
Six ways large language models are changing healthcare
Six ways large language models are changing healthcare
Nature Medicine asks six leading AI researchers to explain how LLM-powered chatbots are having an impact on health, from v...
Semaglutide offers new route to cardiovascular risk reduction
Semaglutide offers new route to cardiovascular risk reduction
In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide...
Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Authors and AffiliationsDepartment of Medicine, Columbia University, New York, New York, USAUtpal B. Pajvani & Domenic...
Viral, cellular and immune aspects of non-suppressible HIV-1 viremia
Viral, cellular and immune aspects of non-suppressible HIV-1 viremia
We find that people with non-suppressible human immunodeficiency virus (HIV) viremia despite antiretroviral therapy (ART) ...
Retraction Note: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New Yo...
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments f...
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