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Using tumor DNA methylomes to predict cancer metastasis to the brain
Using tumor DNA methylomes to predict cancer metastasis to the brain
Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will d...
Obesity predisposes to specific cancer driver mutations
Obesity predisposes to specific cancer driver mutations
A large-scale genomic analysis reveals associations between body mass index and certain driver mutations in various cancer...
Citizen science as an instrument for women’s health research
Citizen science as an instrument for women’s health research
Women’s health research is receiving increasing attention globally, but considerable knowledge gaps remain. Across m...
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
A prospective, multicenter study of patients hospitalized with COVID-19 demonstrates objective global cognitive impairment...
Internet use linked to better mental health in older adults
Internet use linked to better mental health in older adults
According to a large international study, Internet use among adults 50 or more years of age correlates with reduced depres...
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Genetic basis of early onset and progression of type 2 diabetes in South Asians
South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for...
Early readout shows promise of genomic newborn screening
Early readout shows promise of genomic newborn screening
Interim results from a large, ongoing study shows that genomic newborn screening identifies treatable conditions that woul...
Lifestyle interventions for cardiometabolic health
Lifestyle interventions for cardiometabolic health
Unhealthy lifestyle behaviors such as poor diets and physical inactivity account for most of the cardiometabolic disease (...
Evaluating the clinical benefits of LLMs
Evaluating the clinical benefits of LLMs
Although large language models (LLMs) show promise in controlled settings, a study now exposes their limitations in real-w...
Author Correction: Anakinra in Sanfilippo syndrome: a phase 1/2 trial
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
How psilocybin affects the brain
How psilocybin affects the brain
A longitudinal imaging study finds that psilocybin ‘desynchronizes’ the human brain, dissolving network connections linked...
ADC superior to chemotherapy in recurrent cervical cancer
ADC superior to chemotherapy in recurrent cervical cancer
The antibody–drug conjugate (ADC) tisotumab vedotin resulted in improved progression-free and overall survival, leading to...
Gastric cancer prevention by community eradication of Helicobacter pylori: a cluster-randomized controlled trial
Gastric cancer prevention by community eradication of Helicobacter pylori: a cluster-randomized controlled trial
Gastric cancer is a leading cause of cancer-related deaths in China. Affecting more than 40% of the world’s populati...
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial
Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay the loss of β-cells but needs to ha...
Western diets and chronic diseases
Western diets and chronic diseases
‘Westernization’, which incorporates industrial, cultural and dietary trends, has paralleled the rise of nonco...
Cranioencephalic functional lymphoid units in glioblastoma
Cranioencephalic functional lymphoid units in glioblastoma
The ecosystem of brain tumors is considered immunosuppressed, but our current knowledge may be incomplete. Here we analyze...
Combination treatment for immune-mediated HIV remission
Combination treatment for immune-mediated HIV remission
In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of v...
Microplastics at heart of the problem
Microplastics at heart of the problem
Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiov...
A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providin...
Going the extra mile to increase vaccine uptake
Going the extra mile to increase vaccine uptake
Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine upta...
Large language models for reducing clinicians’ documentation burden
Large language models for reducing clinicians’ documentation burden
Evaluation of a clinical summarization method based on GPT-4 suggests that such models might reduce the documentation burd...
Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
The authors have determined that the cell line referred to as AT3 breast cancer in the paper is instead Lewis lung carcino...
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
These authors contributed equally: Leandro C Cerchietti, Eloisi C LopesDivision of Hematology and Oncology, Weill Cornell ...
Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness
Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness
Most suspected cholera cases are not tested for Vibrio cholerae. Integrating systematic testing into cholera surveillance ...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
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